A5100392432- Systemic Lupus Erythematosus Research
- Asthma and respiratory diseases
- Pulmonary Hypertension Research and Treatments
- Rheumatoid Arthritis Research and Therapies
- Autoimmune and Inflammatory Disorders Research
- Renal Diseases and Glomerulopathies
- Atherosclerosis and Cardiovascular Diseases
- Pediatric health and respiratory diseases
- Parvovirus B19 Infection Studies
- Psoriasis: Treatment and Pathogenesis
- Helicobacter pylori-related gastroenterology studies
- Immunodeficiency and Autoimmune Disorders
- Spondyloarthritis Studies and Treatments
- Allergic Rhinitis and Sensitization
- MicroRNA in disease regulation
- Nosocomial Infections in ICU
- Monoclonal and Polyclonal Antibodies Research
- Cytomegalovirus and herpesvirus research
- Gastroesophageal reflux and treatments
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Pneumonia and Respiratory Infections
- Vasculitis and related conditions
- Immune Cell Function and Interaction
- Chronic Lymphocytic Leukemia Research
- Systemic Sclerosis and Related Diseases
Third Affiliated Hospital of Sun Yat-sen University
2014-2025
Sun Yat-sen University
2014-2025
Shanxi Academy of Medical Sciences
2025
Shanxi Medical University
2015-2025
Heilongjiang University of Chinese Medicine
2025
Shanghai Traditional Chinese Medicine Hospital
2025
Peking Union Medical College Hospital
1992-2024
Jining Medical University
2024
Academy of Medical Sciences
2015-2024
Second Affiliated Hospital of Zhejiang University
2024
Abstract Clinical experience suggests increased incidences of neonatal jaundice when air quality worsens, yet no studies have quantified this relationship. Here we reports investigations in 25,782 newborns showing an increase newborn’s bilirubin levels, the indicator risk, by 0.076 (95% CI: 0.027–0.125), 0.029 (0.014–0.044) and 0.009 0.002–0.016) mg/dL per μg/m 3 for PM 2.5 exposure concentration ranges 10–35, 35–75 75–200 , respectively. The response is 0.094 (0.077–0.111) 0.161...
Tumor necrosis factor (TNF) alpha and interleukin-17 (IL-17) are thought to be involved in the pathogenesis of Takayasu arteritis (TAK), TNF inhibitors (TNFi) recommended for treatment TAK. The present study was undertaken investigate efficacy secukinumab, an IL-17A monoclonal antibody, compared with TNFi.This a prospective, single-center, open-label cohort study. Patients active TAK who did not respond glucocorticoids combined 2 immunosuppressive agents were treated either secukinumab or...
Human epididymis protein 4 (HE4), has recently been reported as a mediator of renal fibrosis. However, serum HE4 levels appear in large number patient samples with chronic kidney disease (CKD), and the relationship these to severity fibrosis is unknown.In 427 patients at different stages CKD excluding gynecologic cancer 173 healthy subjects, concentrations were tested by chemiluminescent microparticle immunoassay. Renal biopsy was performed on 259 subjects. Histological findings evaluated...
BACKGROUND As a common nosocomial infection, ventilator-associated pneumonia (VAP) often has high mortality. This study aimed to assess the risk factor for mortality owing VAP. MATERIAL AND METHODS retrospective clinical audit screened medical records between period of January 2014 and December 2017. All patients under mechanical ventilation MV) ≥72 hours were against previously reported diagnostic criteria The obtained cases documented diagnosis RESULTS In all, 145 (5.0%) diagnosed with VAP...
Abstract Background Despite the availability of free tuberculosis (TB) diagnosis and treatment, TB care still generates substantial costs that push people into poverty. We investigated out-of-pocket (OOP) payments for assessed resulting economic burden consequences those with varying levels household income in eastern China. Methods A cross-sectional study was conducted among patients national programme networks TB-related direct OOP costs, time loss, coping strategies were across households...
To provide real-world data and summarize current clinical evidence on the efficacy safety of sirolimus in active systemic lupus erythematosus (SLE) patients.This was a prospective study. Included SLE patients should have Systemic Lupus Erythematosus Disease Activity Index 2000 (SLEDAI-2K) ⩾ 2. They were treated with followed up regularly. The SLEDAI-2K, Physician Global Assessment (PGA), serological activity indices, remission organ manifestations evaluated. We also performed meta-analysis...
Objective. To identify the clinical characteristics, magnetic resonance imaging (MRI) results, and prognostic factors of neuropsychiatric (NP) systemic lupus erythematosus (SLE; NPSLE) in a relatively large patient series China. Methods. Data patients with NPSLE at Peking Union Medical College Hospital (PUMCH) were collected retrospectively from June 2012 to 2016. compared 220 non-NPSLE patients. Survival rates evaluated using Kaplan-Meier curves, log-rank test, Cox proportional hazards...
Pulmonary arterial hypertension (PAH) is a severe complication of systemic lupus erythematosus (SLE). However, the genetic signatures SLE-associated PAH have not been well studied. We aimed to identify variants implicated in susceptibility within major histocompatibility complex (MHC) region and assess contribution clinical outcomes.A total 172 patients with confirmed by right heart catheterization, 1,303 SLE without PAH, 9,906 healthy controls were included. Deep sequencing MHC was...
Apolipoprotein E (ApoE) is a factor involved in Alzheimer's disease, which recently attracted great attention as an important protein related to tumorigenesis and metastasis. However, serum ApoE levels its diagnosis prognosis value non-small cell lung cancer (NSCLC) patients are still unknown. In 196 NSCLC 203 healthy controls, was measured by turbidimetric immunoassay. The associations of with the clinicopathological characteristics clinical outcomes were analyzed. Serum obviously elevated...
Purpose: Nosocomial pneumonia is a common nosocomial infection that includes hospital-acquired (HAP) and ventilator-associated pneumonia(VAP). It an important cause of morbidity mortality in hospitalized patients. This study aimed to evaluate the differences microbial etiology outcomes between HAP VAP, particularly related risk factors multidrug-resistant organism (MDRO) causing VAP. Patients methods: single-center retrospective, observational included patients with HAP/VAP. Clinical...
Hospital-acquired pneumonia (HAP) remains an important cause of morbidity and mortality despite advances in antimicrobial therapy. The emergence Gram-negative bacteria (GNB) is major concern. objective this study was to describe the epidemiology, microbiology, predictors infection-related 30-day HAP with GNB.We performed a retrospective, single-center analysis patients GNB occurring from January 2014 December 2017. Univariate multivariate analyses were identify risk factors for...
Post-stroke depression (PSD) constitutes a significant complication that influences both patient survival and functional recovery following stroke. Despite its prevalence, PSD still lacks long-term, safe effective treatment measure. Remote ischemic conditioning (RIC) is simple noninvasive procedure exert neuroprotective effects. This pilot study aims to investigate the efficacy, safety, feasibility of RIC as preventive measure against PSD. Acute stroke patients within 15 days post-event were...
There are relatively few studies related to new-onset refractory status epilepticus (NORSE), in which patients with cryptogenic NORSE have more frequent and longer duration seizures than a clear etiology, likely develop drug-refractory epilepsy prognosis of severe cognitive impairment. We conducted series case investigate the treatment options NORSE. Seven adult treated at Third Hospital Shanxi Medical University between June 2016 April 2022 were reviewed. collected basic information...
Pharyngiyan tablet is a traditional Chinese medicine (TCM) renowned for its efficacy in moisturizing the lungs, clearing throat. However, it exhibits quality variations due to discrepancies regulatory standards and challenges comprehensive evaluation. In this study, ultra-performance liquid chromatography-quadrupole time-of-flight tandem mass spectrometry (UPLC-Q-TOF-MS/MS) was used qualitatively analyze chemical composition of pharyngiyan tablets. Full analysis detected 131 constituents....
ABSTRACT Acetaminophen (APAP) is a major cause of acute liver injury (ALI), and N‐acetylcysteine the only approved detoxification drug. Nimbolide (Nim), which isolated from neem tree ( Azadirachta indica ), possesses protective properties against multiple diseases, including pancreatitis, autoimmune hepatitis, arthritis, diabetic cardiomyopathy. Here, we investigated effect nimbolide on APAP‐induced ALI. Male C57BL/6J mice were used to establish an ALI model via APAP administration (500...
Toll-like receptor 4 (TLR4), as one of the most important pathogen pattern recognitions (PPRs) plays a central role in elicitation innate immunity and mediation adaptive responses against foreign antigens. However, little is known roles TLR4 immune biliary epithelial cells (BECs) induced by Clonorchis sinensis, parasite significance human health. In present study, primary mouse intrahepatic (MIBECs) were pre-treated with inhibitor peptide or control then stimulated excretory/secretory...
Objective To develop and conduct an initial validation of the Damage Index for IgG4-related disease (IgG4-RD DI). Methods A draft index items assessing organ damages in patients with IgG4-RD was generated by experts from Chinese Consortium (CIC). The preliminary DI refined using Delphi method, a final version consensus. 40 cases representing four types clinical scenarios were then selected, each two time points assessment at least 3 years follow-up. 48 rheumatologists 35 hospitals nationwide...