A5100728774- Renal Diseases and Glomerulopathies
- Inflammasome and immune disorders
- Systemic Lupus Erythematosus Research
- Renal cell carcinoma treatment
- Sphingolipid Metabolism and Signaling
- Neuropeptides and Animal Physiology
- Ferroptosis and cancer prognosis
- PI3K/AKT/mTOR signaling in cancer
- Renal and related cancers
- Mast cells and histamine
- Endoplasmic Reticulum Stress and Disease
- Cancer-related gene regulation
- Pancreatitis Pathology and Treatment
- Cardiac Ischemia and Reperfusion
- Immune Cell Function and Interaction
- Liver Diseases and Immunity
- Epigenetics and DNA Methylation
- Bladder and Urothelial Cancer Treatments
- Nanoplatforms for cancer theranostics
- Signaling Pathways in Disease
- RNA modifications and cancer
- Cardiac Fibrosis and Remodeling
- Hybrid Renewable Energy Systems
- Urological Disorders and Treatments
- COVID-19 diagnosis using AI
Shanxi Medical University
2013-2025
Tongji Hospital
2018-2024
Huazhong University of Science and Technology
2018-2024
Zhujiang Hospital
2024
Southern Medical University
2024
Boston University
2018
Second Hospital of Shanxi Medical University
2013
Xuzhou Children Hospital
2012
China University of Geosciences
2010
Background Immune checkpoint inhibitors (ICIs) are the standard of care for metastatic renal cell carcinoma (RCC); however, most patients develop de novo or acquired resistance to ICIs. Oxidative phosphorylation (OXPHOS) has been rarely explored as a potential target correcting ICI resistance. Methods We systematically analyzed RNA sequencing and clinical data from CheckMate, JAVELIN Renal 101, NCT01358721 trials, clinicopathological 25 Tongji Hospital investigate relationship between OXPHOS...
Intermedin (IMD) is a novel member of the calcitonin/calcitonin gene-related peptide family. Endoplasmic reticulum stress (ERS) has been implicated in pathology renal ischemia/reperfusion (IRI). In present study, we investigated whether IMD could reduce ERS damage after ischemia. The kidneys SD rats were subjected to 45 min warm ischemia followed by 24 h reperfusion. hypoxia/reoxygenation(H/R) model NRK-52E cells consisted hypoxia for 1 and reoxygenation 2 h. was over-expressed vivo vitro...
Abstract Non‐SMC condensin I complex subunit H (NCAPH) is reported to play an important role and be a poor prognostic factor in various cancers. However, the function regulatory mechanism of NCAPH clear cell renal carcinoma (ccRCC) remain unknown. The roles on ccRCC growth were detected vitro vivo assays. was explored by immunoprecipitation assay, ubiquitination ChIP RIP luciferase reporter assay RNA pull‐down assay. immunoregulation also flow cytometry, T cell‐mediated tumour killing...
Diabetic kidney disease (DKD) is the primary factor that causes chronic and increasing mortality morbidity due to its severe consequences. Isoliquiritigenin (ISL) element of licorice root physiologically active has antifree radical, antioxidation, antiapoptotic properties. However, effect ISL on DKD still unclear needs be further improved. This study aims evaluate renoprotective effects diabetes-induced renal injury explores underlying mechanisms involved. Male C57BL/6 mice are fed a...
Abstract The Warburg effect‐related metabolic dysfunction of the tricarboxylic acid (TCA) cycle has emerged as a hallmark various solid tumors, particularly renal cell carcinoma (RCC). RCC is characterized by high immune infiltration and thus recommended for immunotherapeutic interventions at an advanced stage in clinical guidelines. Nevertheless, limited benefits immunotherapy have prompted investigations into underlying mechanisms, leading to proposal dysregulation‐induced immunoevasion...
<b><i>Background:</i></b> IgA nephropathy (IgAN) is the most frequent glomerulonephritis worldwide. Different therapeutic approaches have been tested against IgAN. The present study was designed to explore renoprotective potential of low-dose mammalian target rapamycin (mTOR) inhibitor in an IgAN rat model and possible mechanism action. <b><i>Methods:</i></b> After establishing model, rats were randomly divided into four groups: control,...
IgA nephropathy is the most frequent type of glomerulonephritis worldwide. The role cell cycle regulation in pathogenesis has been studied. present study was designed to explore whether rapamycin ameliorates via cycle-dependent mechanisms. After establishing an model, rats were randomly divided into four groups. Coomassie Brilliant Blue used measure 24-h urinary protein levels. Renal function determined using autoanalyzer. Proliferation assayed Proliferating Cell Nuclear Antigen (PCNA)...
Intermedin/adrenomedullin 2 (IMD/ADM2) is a newly discovered peptide closely related to adrenomedullin. We recently reported that IMD/ADM2 gene transfer could significantly reduce renal ischaemia/reperfusion injury. In this study, we evaluated the effect of on cell proliferation and regeneration in cultured rat tubular epithelial line (NRK-52E) hypoxia-reoxygenation (H/R) injury.The H/R model NRK-52E cells consisted hypoxia for 1 h reoxygenation h. was overexpressed using vector...
Background: Ischemia-reperfusion injury (IRI) is a major cause of acute kidney (AKI) and increases the risk subsequently developing chronic disease. Angiogenesis has been shown to play an important role in reducing renal after ischemia reperfusion. In this study, we investigated whether IMD could reduce IRI by promoting angiogenesis. Methods: The kidneys Wistar rats were subjected 45 min warm followed 24 h was overexpressed vivo using vector pcDNA3.1-IMD transfected ultrasound-mediated...
Background: To compare the effectiveness of cytoreductive partial nephrectomy (CPN) and radical (CRN) in treatment metastatic T1–T2 renal cell carcinoma (RCC).
Amiodarone (AM) is one of the most effective antiarrhythmic drugs and normally administrated by intravenous infusion which liable to cause serious phlebitis. The therapeutic for preventing this complication are limited. Intermedin (IMD), a member calcitonin family, has broad spectrum biological effects including anti-inflammatory effects, antioxidant activities, antiapoptosis. But now, protective IMD against amiodarone-induced phlebitis underlying molecular mechanism not well understood. In...
Intermedin (IMD) is a member of the calcitonin gene-related peptide (CGRP) superfamily and pro-angiogenic factor. In present study, we identified activation Wnt/β-catenin signaling pathway by IMD. Adding CoCl2 HUVECs was used to establish an in vitro model. The migration measured wound healing assays transwell assays. Capillary formation using tube Immunocytochemistry (ICC) analysis evaluate VEGF RAMP2 expression HUVECs. relevant molecules were detected with western blot. Our study shows...
The inhibition of mesangial cell proliferation has become an important therapy for the prevention glomerular proliferation‑associated diseases. combined application immunosuppressants with multiple targets presents a novel direction in treatment kidney present study was designed to explore inhibitory effects tacrolimus (TAC) mycophenolate mofetil (MMF) on cells based cycle. In vitro, levels index markers, Ki67 and cyclin D1, human (HMCs) were determined by immunofluorescence staining western...