A5064551109- Chronic Myeloid Leukemia Treatments
- Acute Myeloid Leukemia Research
- Chronic Lymphocytic Leukemia Research
- Acute Lymphoblastic Leukemia research
- Developmental Biology and Gene Regulation
- Monoclonal and Polyclonal Antibodies Research
- Genomics and Chromatin Dynamics
- Lymphoma Diagnosis and Treatment
- RNA Research and Splicing
- T-cell and Retrovirus Studies
- Congenital heart defects research
- RNA modifications and cancer
- T-cell and B-cell Immunology
- Glycosylation and Glycoproteins Research
- Eosinophilic Disorders and Syndromes
- Wnt/β-catenin signaling in development and cancer
- RNA and protein synthesis mechanisms
- Cancer-related Molecular Pathways
- PI3K/AKT/mTOR signaling in cancer
- Microbial infections and disease research
- Epigenetics and DNA Methylation
- Viral Infectious Diseases and Gene Expression in Insects
- Cancer-related gene regulation
- Hematopoietic Stem Cell Transplantation
- Animal Genetics and Reproduction
Stowers Institute for Medical Research
2005-2021
University of Kansas Medical Center
2005-2021
University Medical Center
2004-2021
University of Kansas
2003-2018
Charité - Universitätsmedizin Berlin
2010
University Hospital and Clinics
2006-2008
University of Missouri–Kansas City
2006
Institute of Cancer Research
1987-2000
Institut Curie
2000
Centre National de la Recherche Scientifique
2000
Jeramiah Smith, Weiming Li and colleagues report the whole-genome sequence of sea lamprey, Petromyzon marinus, representing a vertebrate lineage diverged from humans ~500 million years ago. Their analyses define key evolutionary events in lineages provide evidence for two duplication occurring before divergence ancestral lamprey jawed (gnathostome) lineages. Lampreys are representatives an ancient that our own ∼500 By virtue this deeply shared ancestry, (P. marinus) genome is uniquely poised...
A common landmark of activated genes is the presence trimethylation on lysine 4 histone H3 (H3K4) at promoter regions. Set1/COMPASS was founding member and only H3K4 methylase in Saccharomyces cerevisiae; however, mammals, least six methylases, Set1A Set1B MLL1 to MLL4, are found COMPASS-like complexes capable methylating H3K4. To gain further insight into different roles functional targets for we have undertaken a genome-wide analysis methylation patterns wild-type Mll1(+/+) Mll1(-)(/)(-)...
The sea lamprey (Petromyzon marinus) serves as a comparative model for reconstructing vertebrate evolution. To enable more informed analyses, we developed new assembly of the germline genome that integrates several complementary data sets. Analysis this highly contiguous (chromosome-scale) shows both chromosomal and whole-genome duplications have played significant roles in evolution ancestral genomes, including chromosomes carry six HOX clusters. also contains hundred genes are reproducibly...
The polymerase chain reaction (PCR) was used to detect clonal rearrangements of the immunological heavy gene in frozen samples human lymphoid tissue. DNA sequences rearranged genes were amplified using oligomeric primers predicted from conserved variable (VH) and joining (JH) regions. On polyacrylamide gel electrophoresis, polyclonal B cell proliferations showed a "smear", probably due lengths diversity (DH) region N regions separating VH DH JH In contrast, lymphomas clear single band eight...
Epithelial stem cells (EP-SCs) located in the bulge region of a hair follicle (HF) have potential to give rise stem/progenitor that migrate down regenerate HFs. Bone morphogenetic protein (BMP) signaling has been shown regulate HF cycle by inhibiting anagen induction. Here we show active BMP functions prevent EP-SC activation and expansion. Dynamic expression Noggin, antagonist, releases EP-SCs from BMP-mediated restriction, leading initiation phase. Experimentally induced conditional...
Five cloned genes encoding the mouse ribosomal protein L30 were isolated from a recombinant DNA library and characterized by restriction mapping nucleotide sequence analysis. Only one of these has introns is expressed; others are inactive processed pseudogenes. The expressed gene consists five exons four spanning 2,723 nucleotides. Transcripts this into mature mRNA pathways that exhibit both constraints flexibility with regard to order intron excision. which 457 468 nucleotides in length...
We describe the cloning of a novel homeodomain-contalning gene, which is highly conserved between mouse and human. The human cDNA was initially isolated from haematopoietic tissue denoted HEX (haematopoletlcally expressed homeobox). Sequence analysis coding sequences partial shows that homeodomaln most closely related to those Hlx HOX11 proteins. gene present as single copy in genome. Analysis murine genomic DNA shows, addition an intron-contalnlng homologous HEX, presence processed has...
Journal Article Nucleotide sequence of both reciprocal translocation junction regions in a patient with Ph positive acute lymphoblastic leukaemia, breakpoint within the first intron BCR gene Get access M.J.M. van der Feltz, Feltz * *To whom correspondence should be addressed Search for other works by this author on: Oxford Academic PubMed Google Scholar M.K.K. Shivji, Shivji P.B. Allen, Allen N. Heisterkamp, Heisterkamp 1Childrens Hospital Los Angeles4650 Sunset Boulevard, Angeles, CA 90027,...
Tumor-initiating stem cells (TSCs) are critical for drug resistance and immune escape. However, the mutual regulations between TSC tumor microenvironment (TME) remain unclear. Using DNA-label retaining, single-cell RNA sequencing (scRNA-seq), other approaches, we investigated intestinal adenoma in response to chemoradiotherapy (CRT), thus identifying therapy-resistant TSCs (TrTSCs). We find bidirectional crosstalk TME using CellPhoneDB analysis. An intriguing finding is that shape into a...
The MLL gene, the closest human homologue to Drosophila trithorax undergoes chromosomal translocation with a large number of different partner genes in both acute lymphoid and myeloid leukemias. We have identified new EEN , fused case leukemia. gene is located on chromosome 19p13, where two other genes, ENL ELL / MEN also been identified. deduced protein 368 aa contains central α-helical region C-terminal Src homology 3 (SH3) domain most similar SH3 found Grb2/Sem-5/Drk family genes....
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