A5056347357- Trauma and Emergency Care Studies
- Cardiac Arrest and Resuscitation
- Sepsis Diagnosis and Treatment
- Trauma, Hemostasis, Coagulopathy, Resuscitation
- Cardiac, Anesthesia and Surgical Outcomes
- Emergency and Acute Care Studies
- Traumatic Brain Injury and Neurovascular Disturbances
- Hip and Femur Fractures
- Injury Epidemiology and Prevention
- Respiratory Support and Mechanisms
- Gun Ownership and Violence Research
- Mitochondrial Function and Pathology
- Abdominal Trauma and Injuries
- Blood transfusion and management
- Cardiac Ischemia and Reperfusion
- Hernia repair and management
- Trauma Management and Diagnosis
- Intensive Care Unit Cognitive Disorders
- Appendicitis Diagnosis and Management
- Palliative Care and End-of-Life Issues
- Venous Thromboembolism Diagnosis and Management
- Abdominal Surgery and Complications
- Thermal Regulation in Medicine
- Heme Oxygenase-1 and Carbon Monoxide
- Renal function and acid-base balance
The Ohio State University
2020-2023
The Ohio State University Wexner Medical Center
2020-2023
St. Anthony Hospital
2023
National Coalition for Cancer Survivorship
2023
University of Washington
2023
St. Anthony Hospital
2023
Brigham and Women's Hospital
2001-2023
United States Army Medical Research and Development Command
2023
Chapter Arts Centre
2023
University of Pennsylvania
2012-2022
Jeramiah Smith, Weiming Li and colleagues report the whole-genome sequence of sea lamprey, Petromyzon marinus, representing a vertebrate lineage diverged from humans ~500 million years ago. Their analyses define key evolutionary events in lineages provide evidence for two duplication occurring before divergence ancestral lamprey jawed (gnathostome) lineages. Lampreys are representatives an ancient that our own ∼500 By virtue this deeply shared ancestry, (P. marinus) genome is uniquely poised...
Conventional T (Tcon) cells and Foxp3+ T-regulatory (Treg) are thought to have differing metabolic requirements, but little is known of mitochondrial functions within these cell populations in vivo. In murine studies, we found that activation both Tcon Treg led myocyte enhancer factor 2 (Mef2)-induced expression genes important oxidative phosphorylation (OXPHOS). Inhibition OXPHOS impaired function compared wild-type disproportionally affected cells. Deletion Pgc1α or Sirt3, which key...
The outcomes of firearm injuries in the United States are devastating. Although mortality and costs have been investigated, long-term after surviving a gunshot wound (GSW) remain unstudied.
Pyruvate has been shown to be protective in numerous vitro and vivo models of oxidant-mediated cellular or organ system injury. Unfortunately, the usefulness pyruvate as a therapeutic agent is abrogated by its very poor stability solution. In an effort take advantage ability scavenge reactive oxygen species while avoiding problems associated with instability solution, we sought determine whether simple derivative, ethyl pyruvate, would animal model species-mediated tissue injury, namely...
To describe variability in the burden of firearm violence by race, income, and place an urban context.We used Philadelphia Police Department data from 2013 to 2014 calculate assault rates within census block groups for both victim residence event locations, stratifying race group income. We cartographic modeling determine variations incidence neighborhood place.The overall rate was 5.0 times higher (95% confidence interval [CI] = 4.5, 5.6) Black people compared with White people. Firearm...
Current therapies for traumatic blood loss focus on hemorrhage control and volume replacement. Severe hemorrhagic shock, however, is associated with a state of arginine vasopressin (AVP) deficiency, supplementation this hormone may decrease the need products in resuscitation.To determine whether low-dose AVP patients trauma (hereinafter referred to as patients) shock decreases their transfused during resuscitation.This randomized, double-blind placebo-controlled clinical trial included adult...
The future site of skin appendage development is marked by a placode during embryogenesis. Although Wnt/β-catenin signaling known to be essential for development, it unclear which cellular processes are controlled the and how precise level activity achieved formation. We have investigated roles Lrp4 its potential ligand Wise (Sostdc1) in mammary other placodes. mutant mice displayed delay initiation changes distribution number precursor cells leading abnormal morphology, position These...
Hemorrhagic shock may contribute to acute kidney injury (AKI) by profoundly altering renal mitochondrial function. Resveratrol (RSV), a naturally occurring sirtuin 1 (SIRT1) activator, has been shown promote function and reduce oxidative damage in variety of aging-related disease states. We hypothesized that RSV treatment during resuscitation would ameliorate dysfunction decrease following hemorrhagic shock.Using decompensated model, male Long-Evans rats (n = 6 per group) were killed prior...
BACKGROUND Relevant to trauma-induced coagulopathy diagnostics, microfluidic assays allow controlled hemodynamics for testing of platelet and coagulation function using whole blood. METHODS Hemodilution or hyperfibrinolysis was studied under flow with modified healthy Furthermore, also measured blood from trauma patients admitted a Level I center. Platelet deposition PPACK-inhibited perfused over collagen surfaces at wall shear rate 200 s−1, whereas platelet/fibrin corn trypsin...
Trauma-induced coagulopathy occurs in about 25% of injured patients and accounts for 10% deaths worldwide. Upon injury, hemostatic function may decline due to vascular dysfunction, clotting factor deficiencies, hyperfibrinolysis, and/or platelet dysfunction. We investigated agonist-induced calcium signaling platelets obtained over time from trauma patients.Platelets healthy donors were monitored via intracellular mobilization flow cytometry markers (α2bβ3 activation, P-selectin display,...
Hemorrhagic shock depletes nicotinamide adenine dinucleotide (NAD) and causes metabolic derangements that, in severe cases, cannot be overcome, even after restoration of blood volume pressure. However, current strategies to treat acute loss do not target cellular metabolism. We hypothesized that supplemental mononucleotide (NMN), the immediate biosynthetic precursor NAD, would support energetics enhance physiologic resilience hemorrhagic shock. In a rodent model decompensated shock, rats...
Here, we define a gene regulatory network for Hoxa2, responsible temporal and spatial expression in hindbrain development. Hoxa2 plays an important role regulating the regional identity of rhombomere 2 (r2) is only Hox expressed this segment. In study, found that cis-regulatory module consists five elements direct r2 developing hindbrain. Surprisingly, imbedded second coding exon therefore may be constrained by both protein requirements. This highly conserved enhancer two consensus Sox...
BACKGROUND With the increased restrictions on resident work hours, hospitals increasingly are relying advance practice nurses and physician assistants to help meet patient care demand. We have created a workflow model wherein unit-based nurse practitioners (UBNPs) provide minute-to-minute for patients with trauma in one specific unit our hospital, supervision by attending surgeons. Patients may also be admitted other units, where is traditional resident-run (RR) service, again staff. Our aim...
Brain tissue oxygenation (PbtO2)-guided management facilitates treatment of reduced PbtO2 episodes potentially conferring survival and outcome advantages in severe traumatic brain injury (TBI). To date, the nature effectiveness commonly used interventions correcting compromised TBI remains unclear. We sought to identify most common analyze which were effective.A retrospective 7-year review consecutive patients with a monitor was conducted Level I trauma center's intensive care unit or...
Rapamycin extends lifespan in mice, but can have a number of undesirable effects that may ultimately limit its utility humans. The canonical target rapamycin, and the one thought to account for on lifespan, is mammalian/mechanistic complex 1 (mTORC1). We previously shown at least some detrimental side rapamycin are due âoff targetâ disruption mTORC2, suggesting they could be avoided by more specific targeting mTORC1. However, mTORC1 inhibition per se reduce mRNA expression mitochondrial...
Interhospital transfer (IHT) is associated with mortality in medical and mixed intensive care units (ICUs), but few studies have examined this relationship a surgical ICU (SICU) setting. We hypothesized that IHT increased SICU patients relative to admitted within the hospital. reviewed center databases from tertiary academic over 2-year period. Inclusion criteria included age 18 years or older admission 24 hours greater. Demographic data, service, Acute Physiology Chronic Health Evaluation...