A5102859125- Thyroid Cancer Diagnosis and Treatment
- Thyroid and Parathyroid Surgery
- Nanoplatforms for cancer theranostics
- Ultrasound and Hyperthermia Applications
- Fungal Plant Pathogen Control
- Head and Neck Anomalies
- Radiomics and Machine Learning in Medical Imaging
- RNA modifications and cancer
- Nanoparticle-Based Drug Delivery
- MRI in cancer diagnosis
- RNA Research and Splicing
- Cancer-related molecular mechanisms research
- MicroRNA in disease regulation
- Plant-Microbe Interactions and Immunity
- Synthesis and Biological Evaluation
- Circular RNAs in diseases
- Extracellular vesicles in disease
- Plant Pathogens and Fungal Diseases
- Pancreatic and Hepatic Oncology Research
- Synthesis of Organic Compounds
- Uterine Myomas and Treatments
- 14-3-3 protein interactions
- Phytochemical compounds biological activities
- Endometriosis Research and Treatment
- Cervical Cancer and HPV Research
Weifang University
2024-2025
Tianjin Medical University Cancer Institute and Hospital
2025
Union Hospital
2015-2024
Jilin University
2012-2024
Union Hospital
2018-2023
Northwest A&F University
2016-2020
Yangzhou Vocational University
2019
Shanghai Institute of Organic Chemistry
2019
Peking University
2019
Jilin Medical University
2018
Abstract Thyroid cancer (TC) is a prevalent endocrine malignant whose pathogenic mechanism remains unclear. The aim of the study was to investigate roles long non‐coding RNA (lncRNA) NR2F1‐AS1/miRNA‐338‐3P/ CCND1 axis in TC progression. Differentially expressed lncRNAs and mRNAs tissues were screened out visualized by R program. Relative expression NR2F1‐AS1, miRNA‐338‐3p cyclin D1 ( ) determined quantitative real time polymerase chain reaction. In addition, Western blot analysis adopted for...
To investigate the value of ultrasound elastography (UE) in differentiation between benign and malignant enlarged cervical lymph nodes (LNs).B-mode ultrasound, power Doppler imaging UE were examined to determine LN characteristics. Two kinds methods, 4 scores elastographic classification a strain ratio (SR) used evaluate elastograms.The cutoff point SR had high utility differential diagnosis nodes, with good sensitivity, specificity accuracy.UE is an important aid LNs.
Resistance to first-line chemotherapeutic drugs such as gemcitabine contributes the poor prognosis of patients with pancreatic cancer. MicroRNAs (miRNA) regulate chemoresistance in By analyzing miRNA sequencing dataset cancer from The Cancer Genome Atlas, it was demonstrated that miR-374b-5p expression dramatically reduced tissues compared adjacent normal tissues, well decreased chemoresistant chemosensitive carcinoma tissues. miR-374-5p associated overall and progression-free survival...
Summary YWHAZ (14‐3‐3ζ) plays crucial roles in regulating proliferation, apoptosis, migration, and invasion of gastric cancer (GC) cells. However, its extensive potential mechanisms GC cells remain unknown, need to be researched deeply. In this study, we focus on the role miR‐375/YWHAZ axis epithelial‐to‐mesenchymal transition (EMT) level was assessed by western blot qPCR assays Scratch transwell were used determine migration The protein levels correlative molecules detected blot. regulation...
As a part of our continuing exploration to discover new potential promising fungicide candidates, eighteen sulfonate derivatives (3a–3r) containing kakuol moiety were designed and synthesized. Synthetic tested comprehensively for antifungal activities against four plant pathogenic fungi (Botrytis (B.) cinerea, Valsa (V.) mali, Fusarium (F.) graminearum, Sclerotinia (S.) sclerotiorum), their structure activity relationships summarized. Especially, 3i 3j exhibited remarkable V. with the...
Currently, multifunctional nanotechnology is strongly expected to improve the prospect of treatment and diagnosis. In this study, we synthesized epidermal growth factor (EGFR)-targeted phase-changeable polymer nanoparticles (C-HPNs) loaded with two drugs (C225 10-HCPT) for specific tumor targeting, synergistic chemotherapy, ultrasound imaging under low-intensity focused (LIFU). Cetuximab (C225), an EGFR-targeted monoclonal antibody, was conjugated on surface nanoparticles, leading a...
Abstract Small nucleolar RNA host gene 3 (SNHG3) is a long noncoding (lncRNA), which known to promote oncogenesis in many cancers but its role human papillary thyroid carcinoma (PTC) remains poorly understood. We therefore assessed SNHG3 expression PTC tissues via quantitative reverse transcription polymerase chain reaction. additionally knocked down cells using short‐hairpin RNAs (shRNAs) explore functional roles PTC. The ability of bind specific microRNAs (miRNAs) was predicted...
Abstract Background Data‐driven gating (DDG) is an emerging technology that can reduce the respiratory motion artifacts in positron emission tomography (PET) images. Purpose The aim of this study to use phantom and patient data validate performance DDG with a correction algorithm based on reconstruct, register, average (RRA) method. Methods A customized platform drove (five spheres diameters 10–28 mm) using periodic had duration 3–5 s amplitudes 2–4 cm. Normalized ratio ungated RRA PET...
We identified a novel interactome, circ_0001018/miR-338-3p/SOX4, in papillary thyroid cancer (PTC), and we intended to confirm the regulatory relationship between three study effects of PTC. The bioinformatics method was used screen out circular RNA mRNA interest. A cellular fractionation assay fluorescence situ hybridization (FISH) were conducted prove that circ_0001018 CCT4 (the host gene circ_0001018) primarily localized cytoplasm PTC cell lines. By qRT-PCR analysis, expression SOX4 found...
YWHAZ (14-3-3ζ) has been reported to be a prognostic marker for various tumors and play crucial role in many oncogenic processes, including proliferation, migration invasion.However, the functional mechanism of gastric cancer (GC) are not detailed still require study.Herein, endogenous expression cell line BGC-823 was silenced by YWHAZ-specific short hairpin RNA (shRNA).Our data showed that silencing resulted cycle arrest cells.Further, YWHAZ-silenced cells acquired increased apoptosis rate,...