A5100785446- Virology and Viral Diseases
- Herpesvirus Infections and Treatments
- Virus-based gene therapy research
- Gut microbiota and health
- Monoclonal and Polyclonal Antibodies Research
- Clostridium difficile and Clostridium perfringens research
- Animal Virus Infections Studies
- Transgenic Plants and Applications
- Bacteriophages and microbial interactions
- Viral Infections and Vectors
- Immunotherapy and Immune Responses
- Poxvirus research and outbreaks
- Probiotics and Fermented Foods
- Cytomegalovirus and herpesvirus research
- Plant Virus Research Studies
- Respiratory viral infections research
- Animal Disease Management and Epidemiology
- Microbial infections and disease research
- Salmonella and Campylobacter epidemiology
- Vector-Borne Animal Diseases
- Advanced Radiotherapy Techniques
- Viral Infections and Immunology Research
- Yersinia bacterium, plague, ectoparasites research
- Bacterial Identification and Susceptibility Testing
- Plant-based Medicinal Research
Northwest A&F University
2016-2025
Ministry of Agriculture and Rural Affairs
2025
Tianjin Medical University Cancer Institute and Hospital
2025
Qinghai University
2021-2024
Wuhan Institute of Virology
2013-2021
Chinese Academy of Sciences
2013-2021
Induction of broad and potent neutralizing Abs at the mucosal portals entry remains a primary goal for most vaccines against mucosally acquired viral infections. Selection appropriate adjuvants capable promoting both systemic responses will be crucial development effective immunization strategies. In this study, we investigated whether plasmid codelivery cytokines APRIL, CCL19, or CCL28 can enhance Ag-induced immune to HIV-1 gp140. Our results demonstrated that pCCL19 pCCL28, but not pAPRIL,...
Abstract Background Data‐driven gating (DDG) is an emerging technology that can reduce the respiratory motion artifacts in positron emission tomography (PET) images. Purpose The aim of this study to use phantom and patient data validate performance DDG with a correction algorithm based on reconstruct, register, average (RRA) method. Methods A customized platform drove (five spheres diameters 10–28 mm) using periodic had duration 3–5 s amplitudes 2–4 cm. Normalized ratio ungated RRA PET...
Newcastle disease (ND), which is caused by the virus (NDV), one of most important avian diseases in poultry. Since its discovery 1926, ND has great economic losses to world poultry industry and remains a threat chickens wild birds. Although stringent vaccination policy widely adopted control ND, outbreaks still occur, virulent NDV sporadically isolated from To study pathogenesis provide tools prevent prevalence, novel antibody fragments should be developed. The variable domains heavy chain...
Constant monitoring is performed to elucidate the role of natural hosts in ecology Newcastle disease virus (NDV). In this study, an NDV strain isolated from asymptomatic pigeon was sequenced and analysed. Results showed that full-length genomes isolate were 15,198 nucleotides with gene order 3'-NP-P-M-F-HN-L-5'. This lentogenic, intracerebral pathogenicity index 0.00 a mean time death more than 148 h. The possessed motif -(112)E-R-Q-E-R-L(117)- at F protein cleavage site. addition, 7 13...
There is a lack of an HSV-2 vaccine, in part as the result various factors that limit robust and long-term memory immune responses at mucosal portals viral entry. We previously demonstrated chemokine CCL19 augmented systemic to HIV-1 envelope glycoprotein. Whether such enhanced immunity can protect animals against virus infection remains be addressed. hypothesized using fusion form direct immunogen responsive immunocytes might have advantage over being used combination with immunogen....
An effective HSV-2 vaccine should induce antigen (Ag)-specific immune responses against viral mucosal infection. This study reveals that chemokine CCL19 or CCL28 enhanced glycoprotein D ectodomain (gD-306aa)-induced vaginal virus challenge.
Newcastle disease virus (NDV) which is pathogenic to chickens characterized by dyspnea, diarrhea, nervous disorder and hemorrhages. However, the influence of different virulent NDV strain infection on host gut microbiota composition still poorly understood. In this study, twenty 21-day-old specific pathogen free (SFP) were inoculated with either velogenic Herts33 strain, lentogenic La Sota or sterile phosphate buffer solution (PBS). Subsequently, fecal samples each group collected for 16S...
The efficient proliferation of Newcastle disease virus (NDV) depends on its inhibition host cell innate immunity. V protein acts as a nonstructural which plays significant role in replication, whereas function remains to be further explored. In this study, Musashi RNA binding 1 (MSI1) was selected and interaction with verified by Co-immunoprecipitation (Co-IP) Immuno-colocalization test. Through the transfection pCMV-HA-MSI1 DF-1 cells, overexpression MSI1 reduced particles supernatant but...
When it comes to the prevention of clinical signs and mortality associated with infection Newcastle disease virus (NDV), vaccination has been very effective. However, recent evidence proven that more highly virulent strains are emerging bypass existing immune protection pose a serious threat global poultry industry. Here, novel rescued adenovirus 5-coexpressed chicken granulocyte monocyte colony-stimulating factor (ChGM-CSF) bio-adjuvant C22-hemagglutinin-neuraminidase (HN) boosted chickens'...
Bovine parainfluenza virus type 3 (BPIV3) is a key pathogen associated with bovine respiratory disease complex (BRDC). However, its specific pathogenesis mechanisms have not been fully elucidated. Reverse genetics provides useful method for understanding the pathogenic mechanism of BPIV3. To ensure functionality rescue platforms, we first constructed minigenome (MG) system BPIV3 utilizing 5-plasmid in this investigation. Then, full-length infection clone was obtained from SX-2021 strain, and...
Pigeon paramyxovirus type-1 (PPMV-1) is the causative agent of pigeon Newcastle disease (ND), which has caused huge losses to industry. In this study, a PPMV-1 strain, PPMV-1/QH-01/CH/23, was isolated from sick racing in Qinghai–Tibet Plateau, China 2023. The mean death time chicken embryos and intracerebral pathogenicity index (ICPI) were 76.8 h 1.25, indicating mesogenic strain. morbidity mortality 100% 80%, respectively, both 80% chickens; therefore, isolate velogenic for pigeons...
Yersinia enterocolitica is a zoonotic proto-microbe that widespread throughout the world, causes self-limiting diseases in humans or animals and even leads to sepsis death patients with severe cases. In this study, real-time recombinase polymerase amplification (RPA) assay for pathogenic Y. was established based on ail gene. The results showed RPA detection could be completed within 20 min at an isothermal temperature of 38 °C by optimizing conditions primers Exo probe. Moreover, sensitivity...