A5032606552- Virology and Viral Diseases
- Virus-based gene therapy research
- vaccines and immunoinformatics approaches
- Viral Infections and Vectors
- Animal Virus Infections Studies
- Animal Disease Management and Epidemiology
- Viral Infections and Immunology Research
- interferon and immune responses
- SARS-CoV-2 and COVID-19 Research
- Autophagy in Disease and Therapy
- Herpesvirus Infections and Treatments
- Mosquito-borne diseases and control
- Viral gastroenteritis research and epidemiology
- Plant Virus Research Studies
Northwest A&F University
2021-2025
Abstract Peste des petits ruminants (PPR), caused by the peste virus (PPRV), is a highly contagious disease affecting ruminants. While goats and sheep are well-known hosts, PPRV has also spread to wild ruminants, it remains unclear which ruminant species can be infected. SLAM (Signaling lymphocytic activation molecule) acts as primary receptor for PPRV, playing crucial role in viral infection process. Identifying SLAMs mediate essential understanding potential hosts of vital effective...
Low virulence and strong immunogenicity are quite important for Newcastle disease virus (NDV) producing (ND) living-attenuated vaccine. However, of NDV positively correlates to its virulence. Usually, the velogenic induces stronger immune responses poultry than lentogenic strain, but virulent poses a risk chicken. In this study, we identified chicken interferon (IFN)-stimulated gene 12-2 (ISG12(2)) not only attenuated NDV, also increased ND vaccine strain. First, found that infection or IFNs...
Porcine epidemic diarrhea virus (PEDV) is a porcine enteric coronavirus globally, causing serious economic losses to the global pig industry since 2010. Here, PEDV CH/Yinchuan/2021 strain was isolated in CV777-vaccinated sow farm which experienced large-scale invasion Yinchuan, China, 2021. Our results demonstrated that isolate could efficiently propagate Vero cells, and its proliferation ability weaker than of CV777 at 10 passages (P10). Phylogenetic analysis S gene revealed clustered into...
When it comes to the prevention of clinical signs and mortality associated with infection Newcastle disease virus (NDV), vaccination has been very effective. However, recent evidence proven that more highly virulent strains are emerging bypass existing immune protection pose a serious threat global poultry industry. Here, novel rescued adenovirus 5-coexpressed chicken granulocyte monocyte colony-stimulating factor (ChGM-CSF) bio-adjuvant C22-hemagglutinin-neuraminidase (HN) boosted chickens'...
The interaction between viral proteins and host plays a crucial role in the process of virus infecting cells. Tags such as HA, His, Flag do not interfere with function fusion are commonly used to study protein-protein interactions. Adding these tags will address challenge lack antibodies for screening that interact during infection. Obtaining viruses tagged is crucial. This established new reverse genetic system T7 promoter three plasmids, which efficiently rescued Newcastle disease (NDV)...
<title>Abstract</title> Peste des Petits Ruminants (PPR), caused by the virus (PPRV), is a highly contagious disease affecting ruminants. While goats and sheep are well-known hosts, PPRV has also spread to wild ruminants, it remains unclear which ruminant species can be infected. SLAM (Signaling Lymphocytic Activation Molecule) acts as primary receptor for PPRV, playing crucial role in viral infection process. Identifying SLAMs mediate essential understanding potential hosts of vital...
Porcine epidemic diarrhea virus (PEDV) is a porcine enteric coronavirus globally, especially since 2010, the variants have caused huge economic losses to global pig industry. To develop low-cost, antigen-stable vaccine against PEDV variants, we selected lentogenic Newcastle disease (NDV) as vector express S protein of highly pathogenic variant, and its safety, protective efficacy optimal immune route were evaluated in naive gilts. Our data uncovered that recombinant NDV SpottedDove-S...