A5102318346- Parathyroid Disorders and Treatments
- Bacterial Genetics and Biotechnology
- Bacteriophages and microbial interactions
- Thyroid and Parathyroid Surgery
- Pharmacological Effects of Natural Compounds
- Viral gastroenteritis research and epidemiology
- Plant Water Relations and Carbon Dynamics
- Microbial Natural Products and Biosynthesis
- Algal biology and biofuel production
- Microbial Community Ecology and Physiology
- Magnesium in Health and Disease
- Heart Rate Variability and Autonomic Control
- Mesenchymal stem cell research
- Bamboo properties and applications
- Rice Cultivation and Yield Improvement
- Antibiotic Resistance in Bacteria
- Urban Green Space and Health
- Bacterial biofilms and quorum sensing
- Forest ecology and management
- Traditional Chinese Medicine Studies
- Electrospun Nanofibers in Biomedical Applications
- Metal and Thin Film Mechanics
- Urban Heat Island Mitigation
- Tissue Engineering and Regenerative Medicine
- Medicinal Plant Pharmacodynamics Research
ShanghaiTech University
2024-2025
Shandong First Medical University
2024-2025
Nanjing Medical University
2020-2025
Zhejiang University
2025
Shandong University
2024-2025
State Key Laboratory of Microbial Technology
2024-2025
China Agricultural University
2024
Dalian Maternal and Child Health Hospital
2022-2024
Sichuan University
2024
Regend Therapeutics (China)
2024
Klebsiella pneumoniae is a Gram-negative bacterium within the Enterobacteriaceae family that can cause multiple systemic infections, such as respiratory, blood, liver abscesses and urinary systems. Antibiotic resistance global health threat K. warrants special attention due to its most modern day antibiotics. Biofilm formation critical obstruction enhances antibiotic of . However, knowledge on molecular mechanisms biofilm relation with in limited. Understanding correlation crucial for...
Akkermansia muciniphila is a gram-negative bacterium that colonizes the human gut, making up 3–5% of microbiome. A. promising next-generation probiotic with clinical application prospects. Emerging studies have reported various beneficial effects including anti-cancer, delaying aging, reducing inflammation, improving immune function, regulating nervous system whereas knowledge on its roles and mechanism in infectious disease currently unclear. In this review, we summarized basic...
Prodigiosin (PG) is a red tripyrrole pigment from the prodiginine family that has attracted widespread attention due to its excellent biological activities, including anticancer, antibacterial and anti-algal activities. The synthesis production of PG particular significance, as it potential be utilized in number applications, those pertaining clinical drug development, food safety, environmental management. This paper provides systematic review recent research on PG, covering aspects like...
The fusion of viruses with cellular membranes is a critical step in the life cycle enveloped viruses. This process facilitated by viral proteins, many which are conformationally pH-sensitive. specifics how changes pH initiate this have remained largely elusive. study presents cryo-electron microscopy (cryo-EM) structures prototype class III protein, GP64, its prefusion and early intermediate states, revealing structural intermediates accompanying membrane process. identify involvement...
This study aimed to evaluate and compare the clinicopathologic features of primary fallopian tubal carcinoma (PFTC) high-grade serous ovarian cancer (HGSOC) explore prognostic factors these two malignant tumors. Fifty-seven patients diagnosed with PFTC from 2006 2015 60 HGSOC 2014 complete information were identified at Women's Hospital Zhejiang University. The clinicopathological surgical data collected, survival was followed for 5 years after surgery. Cox proportional risk model used...
The molecular mechanism underlying the elimination of algal cells by fungal mycelia has not been fully understood. Here, we applied transcriptomic analysis to investigate gene expression and regulation at time courses Trametes versicolor F21a during algicidal process. obtained results showed that a total 193, 332, 545, 742 differentially expressed genes were identified 0, 6, 12, 30 h process, respectively. ontology terms enriched into glucan 1,4-α-glucosidase activity, hydrolase lipase...
<title>Abstract</title> Transport of proteins and small molecules across cellular membrane is crucial for bacterial interaction with the environment survival against antibiotics. In Gram-negative bacteria that possess two layers membranes, specialized macromolecular machines are required to transport substrates envelope, often via an indirect stepwise procedure. The major facilitator superfamily (MFS)-type tripartite efflux pumps type I secretion systems likely employ a direct one-step...
Retinal detachment (RD) refers to the separation between neuroepithelium and pigment epithelium layer. It is an important disease leading irreversible vision damage worldwide, in which photoreceptor cell death plays a major role. α-Synuclein (α-syn) reportedly involved numerous mechanisms of neurodegenerative diseases, but association with RD has not been studied. In this study, elevated transcription levels α-syn parthanatos proteins were observed vitreous patients RD. The expression α-syn-...
A recent algicidal mode indicates that fungal mycelia can wrap and eliminate almost all co-cultivated algal cells within a short time span. However, the underlying molecular mechanism is rarely understood. We applied proteomic analysis to investigate process of Trametes versicolor F21a identified 3,754 proteins. Of these, 30 enzymes with endo- or exoglycosidase activities such as β-1,3-glucanase, α-galactosidase, α-glucosidase, alginate lyase chondroitin were significantly up-regulated....
Abstract Fast charging/discharging rate, sustained cycle life, and high power density are irreplaceable virtues of supercapacitors (SCs), these merits can be achieved by selecting suitable active materials designing the rational microstructure. In this work, zinc cobalt sulfde (ZCS) microspheres have been synthesized a simple two‐step method involving an ethylene glycol (EG) mediated solvothermal approach subsequent sulfidation treatment. The formation mechanism is also proposed in detail...
Calciphylaxis is a rare disease characterized histologically by microvessel calcification and microthrombosis, with high mortality no proven therapy. Here, we reported severe uremic calciphylaxis patient progressive skin ischemia, large areas of painful malodorous ulcers, mummified legs. Because the worsening symptoms signs refractory to conventional therapies, treatment human amnion-derived mesenchymal stem cells (hAMSCs) was approved. Preclinical release inspections hAMSCs, efficacy,...
Flagella play a crucial role in the invasion process of Salmonella and function as significant antigen that triggers host pyroptosis. Regulation flagellar biogenesis is essential for both pathogenicity immune escape Salmonella. We identified conserved unknown protein STM0435 new regulator. The ∆stm0435 strain exhibited higher cellular animal infection experiments than wild-type Proteomic transcriptomic analyses demonstrated dramatic increases almost all genes compared to In surface plasmon...
We have developed a method to explore the detailed structure of mean pulse profile pulsars—namely, Gaussian fit separation average (GFSAP) method—in which we model total as superposition several Gaussian-shaped components. PSR B1451-68 has been observed at six frequencies, 170, 271, 400, 649, 950, and 1612 MHz, providing an excellent basis for multifrequency analysis. Applying GFSAP 1451-68's ostensibly triple profile, find strong evidence that it five components in its profile. Based on...
Hepatitis E virus (HEV) is thought to be a zoonotic pathogen that causes serious economic loss and threatens human health. However, there lack of efficient antiviral strategies. As more promising tool for therapy, nanobodies (also named single-domain antibodies, sdAbs) exhibit higher specificity affinity than traditional antibodies. In this study, nanobody anti-genotype four HEV open reading frame 2 (ORF2) was screened using phage display technology, two (nb14 nb53) with high were...
Abstract Background: KRAS is the best-known oncogene but had long been considered ‘undruggable’ until approval of first G12C inhibitor sotorasib in 2021. However, most current clinical-stage inhibitors target mutation. Inhibitors other mutants such as G12D, frequent mutation human cancer, are needed for patients. We have developed GFH375 (VS-7375), an oral, selective G12D targeting both “ON” (GTP-bound) and “OFF” (GDP-bound) states proteins. The vitro potency, selectivity, vivo efficacy...
Abstract Two new sesquiterpenoid esters, pestalotiopins B and C ( 1 2 , resp.) related to the eremophilane class, together with one known compound, berkleasmin 3 ), were isolated from fermentation broth of plant endophytic fungus Pestalotiopsis photiniae. Their structures relative configurations elucidated by extensive spectroscopic analysis including 1D‐ 2D‐NMR (HSQC, HMBC, NOESY), MS experiments. Compound has an interesting lactam structure, this type a structure is reported for first time.
Molybdenum/molybdenum carbide (Mo/Mo 2 C) gradient interlayers were prepared via double glow plasma surface alloying (DGPSA) technique onto cemented (WC–Co) substrates for diamond deposition. The morphologies, phase composition and adhesion of the investigated, as well their effect on subsequent results indicated that Mo/Mo C interlayer deposited WC–Co substrate was composed 4.0-[Formula: see text]m-thick diffusion layer 2.7-[Formula: deposition layer. Mo concentration decreased gradually...