A5101817574- Alzheimer's disease research and treatments
- Angiogenesis and VEGF in Cancer
- Neuroinflammation and Neurodegeneration Mechanisms
- Cancer, Hypoxia, and Metabolism
- Tryptophan and brain disorders
- Breast Implant and Reconstruction
- Ferroptosis and cancer prognosis
- Functional Brain Connectivity Studies
- Advanced Neuroimaging Techniques and Applications
- Cancer Immunotherapy and Biomarkers
- Reconstructive Surgery and Microvascular Techniques
- Ubiquitin and proteasome pathways
- Epigenetics and DNA Methylation
- Peripheral Neuropathies and Disorders
- Neonatal and fetal brain pathology
- Computational Drug Discovery Methods
- Neurogenesis and neuroplasticity mechanisms
- Immunotherapy and Immune Responses
- Cell Adhesion Molecules Research
- Reconstructive Facial Surgery Techniques
- Ocular Oncology and Treatments
- Electrospun Nanofibers in Biomedical Applications
- Mesenchymal stem cell research
- Cutaneous Melanoma Detection and Management
- Cerebrospinal fluid and hydrocephalus
Nanjing Medical University
2010-2025
Nanjing Brain Hospital
2020-2025
Jiangsu Province Hospital
2010-2024
Walker (United States)
2021
Beijing Hospital
2020
Suzhou Municipal Hospital
2019
Hangzhou Cancer Hospital
2017
Shanghai Jiao Tong University
2010
Second Military Medical University
2010
Uveal melanoma(UVM) is the most common intraocular malignancy and has a poor prognosis. The clinical significance of necroptosis(NCPS) in UVM unclear.
Hepatocellular carcinoma (HCC) is one of the most common cancers in world and often associated with a poor prognosis. The main reason for this prognosis that inconspicuous early symptoms lead to delayed diagnosis. Treatment options advanced HCC remain limited ineffective. In context, exploration immune microenvironment becomes attractive. study, we divided into cell non-immune subtypes, by single-cell sequencing analysis GEO dataset GSE146115. We found differentially expressed genes two...
To construct a prognosis model of melanoma based on pyroptosis related genes.Melanoma RNA-sequencing data was downloaded from TCGA. First, the lnRNAs to were obtained through Pearson correlation analysis. Then, genes constructed by Cox regression and Lasso regression. Melanoma patients divided into high-risk low-risk groups risk score, differences in immune microenvironment between two explored.We found that group had significantly poorer prognosis, different differed infiltration, m6A...
Non-cognitive behavioral and psychological symptoms often occur in Alzheimer's disease (AD) patients mouse models, although the exact neuropathological mechanism remains elusive. Here, we report hyperactivity with significant inter-individual variability 4-month-old APP/PS1 mice. Pathological analysis revealed that intraneuronal accumulation of amyloid-β (Aβ), c-Fos expression glutamatergic neurons activation astrocytes were more evident frontal motor cortex hyperactive mice, compared to...
Background: Alzheimer's disease (AD) patients are often accompanied by depressive symptoms, but its underlying mechanism remains unclear.The present study aimed to explore the potential role of microRNAs in comorbidity AD and depression.Methods: The miRNAs associated with depression were screened from databases literature then confirmed cerebrospinal fluid (CSF) different ages transgenic APP/PS1 mice.AAV9-miR-451a-GFP was injected into medial prefrontal cortex (mPFC) mice at seven months,...
The major cause of cancer mortality is the metastatic spread tumor cells that can occur via multiple routes, including vascular system and lymphatic system. In this study, we developed an IgG-like fusion protein molecule [vascular endothelial growth factor (VEGF) receptor 31-immunoglobulin (VEGFR31-Ig)] which could simultaneously bind angiogenic VEGF-A lymphangiogenic VEGF-C. Importantly, VEGFR31-Ig exhibited VEGF-A-binding affinity similar to VEGFTrap, most potent binder, VEGF-C-binding...
Background The pathophysiology of keloid formation is not yet understood, so the identification biomarkers for kelod can be one step towards designing new targeting therapies which will improve outcomes patients with keloids or at risk developing keloids. Methods In this study, we performed single-cell RNA sequencing analysis, weighted co-expression network and differential expression analysis based on public databases. And 3 data from in our center were used validation. Besides, QRT-PCR...
Melanoma is a type of cancer with relatively poor prognosis. The development immunotherapy for the treatment patients melanoma has drawn considerable attention in recent years. It great clinical significance to identify novel promising prognostic biomarkers and explore their roles immune microenvironment. solute carrier (SLC) superfamily group transporters predominantly expressed on cell membrane are involved substance transport. SLC16A1 member SLC family, participating transport lactate,...
Metabolic reprogramming is common in various cancers. Targeting metabolism to treat tumors a hot research topic at present. Among them, changes glucose cancer have been widely studied. The Warburg effect maintains high metabolic level the tumor, accompanied by transporters. transmembrane transport of sugar was previously thought be mediated SGLT and GLUT. Recently, Solute Carrier Family(SLC) 45 family may third transporter. But role value SLC45 melanoma, highly malignant skin unclear. Our...
Currently, the role of liquid-liquid phase separation (LLPS) in cancer has been preliminarily explained. However, significance LLPS breast is unclear. In this study, single cell sequencing datasets GSE188600 and GSE198745 for were downloaded from GEO database. Transcriptome data UCSC We divided cells into high-LLPS group low-LLPS by down dimension clustering analysis single-cell set, obtained differentially expressed genes between two groups. Subsequently, weighted co-expression network...
Introduction Visual hallucination is a prevalent psychiatric disorder characterized by the occurrence of false visual perceptions due to misinterpretation in brain. Individuals with Parkinson’s disease often experience both minor and complex hallucinations. The underlying mechanism hallucinations patients commonly attributed dysfunction pathway attention network. However, there limited research on Methods To address this gap, we conducted an experiment involving 13 hallucinations, without...
Varicella-zoster virus (VZV) central nervous system infection is typically observed in immunocompromised patients, and there a lack of studies involving large samples non-immunocompromised individuals. In this study, we retrospectively analyzed 108 patients diagnosed with VZV infection. This retrospective study was conducted the Department Neurology, Affiliated Nanjing Brain Hospital, Medical University, China. Metagenomic next-generation sequencing (mNGS) cerebrospinal fluid (CSF) revealed...
Introduction Blepharoplasty's psychological effects are well-studied, but its impact on social cognition, particularly gaze behavior, remains unexplored. Understanding how cosmetic surgery alters visual attention to faces has implications for patient counseling and interaction research. Objectives & Hypotheses We hypothesized that post-blepharoplasty patients would exhibit altered patterns, specifically increased eyes due heightened self-awareness. Primary outcomes were fixation duration...
Calciphylaxis is a rare disease characterized histologically by microvessel calcification and microthrombosis, with high mortality no proven therapy. Here, we reported severe uremic calciphylaxis patient progressive skin ischemia, large areas of painful malodorous ulcers, mummified legs. Because the worsening symptoms signs refractory to conventional therapies, treatment human amnion-derived mesenchymal stem cells (hAMSCs) was approved. Preclinical release inspections hAMSCs, efficacy,...
Uveal melanoma is a highly malignant tumor in the eye. Its recurrence and metastasis are common, prognosis poor.The transcriptome data of UVM were downloaded from TCGA database, single cell sequencing dataset GSE139829 was GEO database. Weighted co-expression network analysis used to explore modules associated with m7G. Lasso regression construct M7G-related prognostic signature. Immune infiltration significance model immune microenvironment. Finally, assays function key genes MUM-2B OCM-1...
Keloid is a disease that seriously affects the aesthetic appearance of body. In contrast to normal skin or hypertrophic scars, keloid tissue extends beyond initial site injury. Patients may complain pain, itching, burning. Although multiple treatments exist, none uniformly successful. Genetic advances have made it possible explore differences in gene expression between keloids and skin. Identifying biomarker for beneficial mechanism exploration treatment development keloid. this study, we...
Introduction Available patient-reported outcome (PRO) studies are mainly from single institution or of small sample size, and the variations across hospitals regions were not fully analysed. A multicentre, prospective, outcome-reconstruction oncoplastic cohort (PRO-ROC) will be planned to assess PROs Chinese patients with breast cancer who undergo reconstruction (BR) breast-conserving surgery (OBCS). Methods analysis The inclusion criteria female aged >18 years old BR OBCS. This include...
To screen potential tumor antigens for melanoma vaccine development and identify different immune subtypes.Transcriptional data (HTSEQ-FPKM) clinical information of a 472 Melanoma cohort GDC TCGA (SKCM) were downloaded from the UCSC XENA website (http://xena.ucsc.edu/). Subsequently, transcriptome 210 GSE65904 Gene Expression Omnibus (GEO), large global public database. All expression matrices log2 transformed subsequent analysis. GEPIA, TIMER, IMMPORT databases are also used Cell function...
Background: The fractional amplitude of low-frequency fluctuations (fALFFs) can detect spontaneous brain activity. However, the association between abnormal activity and cognitive function, amyloid protein (Aβ), emotion in Alzheimer’s disease (AD) patients remains unclear. Objective: This study aimed to survey alterations fALFF different frequency bands relationship activity, depressive mood, function determine potential mechanism AD. Methods: We enrolled 34 AD 32 healthy controls (HC). All...