A5100669170- Venous Thromboembolism Diagnosis and Management
- Cancer-related molecular mechanisms research
- Lipid metabolism and disorders
- Genetic Associations and Epidemiology
- Pulmonary Hypertension Research and Treatments
- MicroRNA in disease regulation
- Circular RNAs in diseases
- RNA modifications and cancer
- Gout, Hyperuricemia, Uric Acid
- Blood Coagulation and Thrombosis Mechanisms
- Ferroptosis and cancer prognosis
- Renin-Angiotensin System Studies
- Drug Transport and Resistance Mechanisms
- Plant Stress Responses and Tolerance
- Biotechnology and Related Fields
- Protease and Inhibitor Mechanisms
- Cardiovascular, Neuropeptides, and Oxidative Stress Research
- Statistical Methods in Clinical Trials
- Pancreatic and Hepatic Oncology Research
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Cholesterol and Lipid Metabolism
- Gallbladder and Bile Duct Disorders
- Receptor Mechanisms and Signaling
- Plant Molecular Biology Research
- Proteoglycans and glycosaminoglycans research
Chinese Academy of Medical Sciences & Peking Union Medical College
2021-2025
China-Japan Friendship Hospital
2021-2025
Academy of Medical Sciences
2023-2024
National Clinical Research
2023-2024
State Key Laboratory of Respiratory Disease
2023
National Clinical Research Center for Digestive Diseases
2022-2023
Peking University
2023
Hepatocellular carcinoma (HCC) is one of the most common cancers in world and often associated with a poor prognosis. The main reason for this prognosis that inconspicuous early symptoms lead to delayed diagnosis. Treatment options advanced HCC remain limited ineffective. In context, exploration immune microenvironment becomes attractive. study, we divided into cell non-immune subtypes, by single-cell sequencing analysis GEO dataset GSE146115. We found differentially expressed genes two...
Background. The incidence of colon adenocarcinoma (COAD) has been increasing over time. Although ferroptosis and long noncoding RNAs (lncRNAs) have extensively reported to participate in the tumorigenesis development COAD, few studies investigated role ferroptosis-related lncRNAs prognosis COAD. Methods. Gene-sequencing clinical data for COAD were obtained from Cancer Genome Atlas database. coexpression network was constructed using known genes. Cox least absolute shrinkage selection...
To construct a prognosis model of melanoma based on pyroptosis related genes.Melanoma RNA-sequencing data was downloaded from TCGA. First, the lnRNAs to were obtained through Pearson correlation analysis. Then, genes constructed by Cox regression and Lasso regression. Melanoma patients divided into high-risk low-risk groups risk score, differences in immune microenvironment between two explored.We found that group had significantly poorer prognosis, different differed infiltration, m6A...
Abstract Genome-wide association studies (GWAS) have identified numerous risk loci for venous thromboembolism (VTE), but it is challenging to decipher the underlying mechanisms. We employed an integrative analytical pipeline transform genetic associations identify novel plasma proteins VTE. Proteome-wide (PWAS) were determined by functional summary-based imputation leveraging data from a genome-wide analysis (14,429 VTE patients, 267,037 controls), blood proteomes (1348 cases), followed...
Determining novel biomarkers for early identification of chronic thromboembolic pulmonary hypertension (CTEPH) could improve patient outcomes. We used the isobaric tag relative and absolute quantitation approach to compare serum protein profiles between CTEPH patients controls. Bioinformatics analyses ELISA were also performed. identified three proteins including heparanase (HPSE), gelsolin (GSN), secreted acidic rich in cysteine (SPARC) had significant changes CTEPH. The receiver operating...
Liver cancer is the fifth most common type of worldwide, and ATP-binding cassette (ABC) transporter family has been widely accepted as a cause multidrug resistance. This study was conducted to explore potential value mechanisms ABC gene in liver hepatocellular carcinoma (LIHC).Data were collected from different public databases. UALCAN, ONCOMINE, GEPIA used retrieve selection differently expressed pathological stage-related genes among family. Principal component analysis (PCA) utilized for...
Genetic factors play a pivotal role in determining venous thromboembolism (VTE) risk, particularly cases of unprovoked early-onset VTE and those with family history. While genome-wide association studies (GWAS) has advanced our understanding, high-quality whole-genome sequencing (WGS) from family-based is essential to elucidate the rare variants. In this study, we performed WGS on 216 individuals 35 Han Chinese pedigrees validated findings 99 high-heritability using whole-exome sequencing....
Aims/Background The application value of endoscopic ultrasound (EUS) in diagnosing duodenal papilla neoplasms (DPNs) remains underexplored. This study aims to evaluate the role EUS and other clinical indicators differentiating between benign malignant DPNs establish a pathological prediction model for DPNs. Methods Clinical imaging data patients were collected. Least absolute shrinkage selection operator (LASSO) regression was employed screen independent predictors. Patients divided into...
Balloon pulmonary angioplasty (BPA) has been proven effective for addressing technically inoperable chronic thromboembolic hypertension (CTEPH). However, the effectiveness of BPA in operable CTEPH patients who, various reasons, did not undergo procedure remains an area requiring exploration. This study sought to assess safety and efficacy such cases. We collected reviewed data from who underwent a consecutive manner. Following multidisciplinary team (MDT) decisions, were classified into two...
Identification and validation of potential biomarkers could facilitate the identification pulmonary arterial hypertension (PAH) thus aid to study their roles in disease process. We used isobaric tag for relative absolute quantitation approaches compare protein profiles between serum PAH patients controls. Bioinformatics analyses enzyme-linked immunosorbent assay (ELISA) controls were performed identify biomarkers. The receiver operating characteristic curve (ROC) analysis was evaluate...
We appreciate the insightful comments and commendations expressed by Lixian Ji Peng Shu regarding our study titled "Association between uric acid risk of venous thromboembolism in East Asian populations: a cohort Mendelian randomization study".1Weng H. Li Zhang Z. et al.Association study.Lancet Reg Health West Pac. 2023; 39100848PubMed Google Scholar Their supportive remarks have both encouraged team reaffirmed importance research within broader scientific discourse.2Ji L. P. Letter to...