A5101594862- Cancer-related molecular mechanisms research
- FOXO transcription factor regulation
- Chronic Kidney Disease and Diabetes
- Renal Diseases and Glomerulopathies
- Circular RNAs in diseases
- Liver Disease Diagnosis and Treatment
- Hepatitis B Virus Studies
- MicroRNA in disease regulation
- Diabetes Treatment and Management
- Hepatitis C virus research
- Pancreatic function and diabetes
- Metabolism, Diabetes, and Cancer
- Ferroptosis and cancer prognosis
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Lipid metabolism and disorders
- Vitamin D Research Studies
- Adipose Tissue and Metabolism
- Autophagy in Disease and Therapy
- Biomarkers in Disease Mechanisms
- Selenium in Biological Systems
- Renal and related cancers
- Genomics, phytochemicals, and oxidative stress
- Genetics, Aging, and Longevity in Model Organisms
- Cancer, Lipids, and Metabolism
- Cardiovascular Health and Risk Factors
First Affiliated Hospital of Zhengzhou University
2015-2024
Xinjiang Medical University
2020-2024
China National Health Development Research Center
2024
Zhengzhou University
2015-2023
Zhejiang University
2020
Union Hospital
2019
Jilin University
2019
Chongqing Medical University
2018
Second Affiliated Hospital of Chongqing Medical University
2018
Dalian Medical University
2018
Abstract Diabetes mellitus, a chronic metabolic disease, often leads to numerous complications, significantly contributing global morbidity and mortality rates. High glucose levels trigger epigenetic modifications linked pathophysiological processes like inflammation, immunity, oxidative stress, mitochondrial dysfunction, senescence various kinds of cell death. Despite glycemic control, transient hyperglycemia can persistently harm organs, tissues, cells, latent effect termed "metabolic...
We recently showed that forkhead-box class O1 (FoxO1) activation protects against high glucose-induced injury by preventing mitochondrial dysfunction in the rat kidney cortex. In addition, FoxO1 has been reported to mediate putative kinase 1 (PINK1) transcription and promote autophagy response oxidative stress murine cardiomyocytes. this study, we ascertained whether overexpressing cortex reverses preestablished diabetic nephropathy animal models. The effect of on mitophagy signaling...
Tubulointerstitial fibrosis (TIF) plays an important role in the progression of diabetic kidney disease (DKD). Forkhead box O1 (FoxO1) is involved regulation metabolism and cell apoptosis, but its function renal TIF induced by DKD less well understood.Human biopsies with normal controls were used to detect apoptosis diabetes. A mouse model kidney-specific overexpression Pax2-3aFoxO1 was established further investigate functions FoxO1 vivo. The vitro roles analyzed HK-2 cells 3aFoxO1-knockin...
The generation of hyperglycemia-induced reactive oxygen species (ROS) is a key event in diabetic nephropathy (DN) development. Since forkhead box class O1 (FOXO1) associated with oxidative stress and shows positive effect on DN, its role renal function the underlying mechanism still unclear. We examined FOXO1 vivo (in transgenic mouse model overexpressing Foxo1) vitro human HK-2 cells knockin (KI) knockout (KO) cultured under high glucose). Renal proximal tubular kidney biopsies from...
MicroRNAs play important roles in the pathogenesis of diabetic nephropathy (DN). In this study, we found that high glucose upregulated miR-27a expression cultured glomerular mesangial cells and kidney glomeruli streptozotocin (STZ)-induced rats. knockdown prevented glucose-induced cell proliferation also blocked upregulation extracellular matrix (ECM)-associated profibrotic genes. Reduction gene by a inhibitor depended upon peroxisome proliferator-activated receptor γ (PPARγ). Further...
Green synthesis of selenium nanoparticles (Se NPs) was performed by mixing Hibiscus sabdariffa (roselle plant) leaf extract with the solution selenious acid (H2SeO3) under continuous stirring conditions resulting roselle plant secondary metabolites conjugated Se NPs. The existence functional groups on surface prepared NPs confirmed Fourier transform infrared spectroscopy (FTIR). formation crystalline anisotropic shape transmission electron microscopy (TEM) images. Furthermore, we also...
Urinary exosomal miRNAs can reflect the physiological and possibly pathophysiological state of cells lining kidney participate in regulation transcription translation proteins, which are playing an important role pathogenesis diabetic disease. In present study, urine was collected from DM DKD patients with a duration more than 10 years urinary miRNA profiling conducted exosomes obtained 3 healthy controls (NC), type 2 diabetes (DM) disease (DKD) using Exiqon's microRNA arrays. total,...
Abstract Thyroid cancer (TC) is a prevalent endocrine malignant whose pathogenic mechanism remains unclear. The aim of the study was to investigate roles long non‐coding RNA (lncRNA) NR2F1‐AS1/miRNA‐338‐3P/ CCND1 axis in TC progression. Differentially expressed lncRNAs and mRNAs tissues were screened out visualized by R program. Relative expression NR2F1‐AS1, miRNA‐338‐3p cyclin D1 ( ) determined quantitative real time polymerase chain reaction. In addition, Western blot analysis adopted for...
Abstract Diabetic kidney disease (DKD) develops in ~40% of patients with diabetes and is the leading cause chronic worldwide. We used single‐cell RNA‐sequencing spatial transcriptomic analyses specimens from DKD. Unsupervised clustering revealed distinct cell clusters, including epithelial cells fibroblasts. also identified differentially expressed genes (DEGs) assessed enrichment, cell–cell interactions. Specific enrichment DKD was evident venous endothelial (VECs) fibroblasts elevated...
Diabetic nephropathy (DN) is acknowledged as a serious chronic complication of diabetes mellitus. Nevertheless, its pathogenesis complicated and unclear. Thus, in this study, the role miR-27a-3p-prohibitin/TMBIM6 signaling axis progression DN was elucidated. Type 2 diabetic db/db mice high glucose (HG)-challenged HK-2 cells were used vivo vitro models. Our results showed that miR-27a-3p upregulated prohibitin or transmembrane BAX inhibitor motif containing 6 (TMBIM6) downregulated kidney...
Retinal endothelial cell (REC) dysfunction induced by diabetes mellitus (DM) is an important pathological step of diabetic retinopathy (DR). Long noncoding RNAs (lncRNAs) have emerged as novel modulators in DR. The present study aimed to investigate the role and mechanism lncRNA Hotair regulating DM-induced REC dysfunction.The retinal vascular preparations immunohistochemical staining assays were conducted assess vessel impairment vivo. EdU, transwell, permeability, CHIP, luciferase...
SIRT1 and FOXO1 play an important role in the pathogenesis of diabetic nephropathy (DN). However, association between genetic polymorphisms susceptibility to type 2 DN (T2DN) has not been explored. In this study, a total 1066 patients with diabetes mellitus (T2DM) (413 without 653 DN) were enrolled. The genotypes three htSNPs (rs3818292, rs4746720, rs10823108) within two (rs2721068, rs17446614) determined by PCR-RFLP. HbA1C, LDL, HDL, TC, TG levels also examined. rs10823108 AA genotype was...
LncRNAs play important roles in the regulation of podocyte apoptosis diabetic nephropathy (DN). However, role lncRNA SNHG17 controlling mitophagy-induced podocytes DN is unknown. This study aims to elucidate underlying mechanism DN. LncRNA and Mammalian Sterile 20-like kinase 1 (Mst1) expression were upregulated glomeruli DM mice high glucose-treated podocytes, whereas Parkin was downregulated. overexpression suppressed mitophagy induced while silencing promoted reduced podocytes. In...
Stroke imposes a heavy economic burden and loss of productivity on individuals society. This study assessed range crucial factors, including direct costs indirect costs, to gauge the implications stroke in China. These outcomes were evaluated with specific reference year 2018, using Chinese yuan (¥) as unit measurement providing corresponding purchasing power parity dollar ($PPP) currency value. A cost-of-illness methodology was used ascertain 2018. Within constraints this approach, defined...
Background: The tumor microenvironment (TME) has been reported to have significant value in the diagnosis and prognosis of cancers. This study aimed identify key biomarkers TME luminal breast cancer (BC). Methods: We obtained immune scores (ISs) stromal (SSs) for Cancer Genome Atlas (TCGA) BC cohort from online ESTIMATE (Estimation STromal Immune cells MAlignant Tumor tissues using Expression data) portal. relationships between ISs SSs overall survival patients were assessed by Kaplan-Meier...