A5100742062- Cancer Immunotherapy and Biomarkers
- Immune Cell Function and Interaction
- Immunotherapy and Immune Responses
- Genomics and Phylogenetic Studies
- T-cell and B-cell Immunology
- Colorectal and Anal Carcinomas
- Salivary Gland Tumors Diagnosis and Treatment
- Bee Products Chemical Analysis
- Healthcare and Venom Research
- Lymphoma Diagnosis and Treatment
- Microbial Community Ecology and Physiology
- Cancer Research and Treatments
- Botanical Research and Applications
- Aquaculture disease management and microbiota
- Insect and Pesticide Research
- Cancer-related gene regulation
- Food Quality and Safety Studies
- CAR-T cell therapy research
- Ubiquitin and proteasome pathways
- Lung Cancer Research Studies
- Plant Disease Resistance and Genetics
- Fungal Biology and Applications
- Mycobacterium research and diagnosis
- Animal Virus Infections Studies
- Aquatic Invertebrate Ecology and Behavior
Hannam University
2010-2025
National Institute of Biological Resources
2024
Beth Israel Deaconess Medical Center
2018-2024
Boston College
2023-2024
Asan Medical Center
2017-2024
University of Ulsan
2012-2024
Ulsan College
2012-2024
CJ CheilJedang (South Korea)
2024
Chonnam National University
2011-2023
University of California, San Diego
2023
Oral tongue squamous cell carcinoma (OTSCC) is the most common oral cavity tumor. In this study, we examined basis for activity of programmed death protein (PD-1)-based immune checkpoint therapy that being explored widely in head and neck cancers. Using multispectral imaging, systematically investigated OTSCC tumor microenvironment (TME) by evaluating frequency PD-1 expression CD8+, CD4+, FoxP3+ tumor-infiltrating lymphocytes (TIL). We also defined cellular sources ligand (PD-L1) to evaluate...
Methionine, essential for human and animal growth, faces increasing demand, contributing significantly to greenhouse gas emissions through digestion nitrogen excretion. This study introduces L-methionine (L-Met) produced biologically from CJ CheilJedang Corp., offering a sustainable alternative the conventional petroleum-based DL-methionine (DL-Met) due its higher bioavailability reduced environmental impact. One of most important aspects lifecycle L-Met is reduce impact during production...
The eradication of the viral reservoir represents major obstacle to development a clinical cure for established HIV-1 infection. Here, we demonstrate that administration N-803 (brand name Anktiva) and broadly neutralizing antibodies (bNAbs) results in sustained control after discontinuation antiretroviral therapy (ART) simian-human AD8 (SHIV-AD8)-infected, ART-suppressed rhesus macaques. N-803+bNAbs treatment induced immune activation transient viremia but only limited reductions SHIV...
Black soldier fly (Hermetia illucens) larvae (BSFL) are rich in protein and have the potential to be used animal feed. The aim of present study was determine immunoprophylactic effect BSFL against Salmonella Gallinarum broiler chicks as an alternative feed additive. Results showed that improved body weight gain increased frequency CD4+ T lymphocyte, serum lysozyme activity, spleen lymphocyte proliferation. Moreover, reinforced bacterial clearance survivability S. Gallinarum. These data...
A multiplex PCR method has been developed to classify extended spectrum β-lactamase (ESBL) and plasmidmediated AmpC (PABL). This consists of the use two four-multiplex PCRs for detection TEM, OXA, SHV, CTX-M, CMY, DHA type β-lactamases. We have compared findings from conventional methods with that this newly typing method. In testing 73 ESBLproducing PABL-producing isolates, 100% isolates were correctly identified as previously characterized types and, 44 β-lactamases additionally 33...
Head and neck squamous cell carcinoma (HNSCC) is an aggressive malignancy characterized by tumor heterogeneity, locoregional metastases, resistance to existing treatments. Although a number of genomic molecular alterations associated with HNSCC have been identified, they had limited impact on the clinical management this disease. To date, few targeted therapies are available for HNSCC, only small fraction patients benefited from these A frequent feature inappropriate activation β-catenin...
Purpose The purpose of this prospective case-control study was to survey the detection rate respiratory viruses in children with Kawasaki disease (KD) by using multiplex reverse transcriptase-polymerase chain reaction (RT-PCR), and investigate clinical implications prevalence during acute phase KD. Methods RT-PCR assays were carried out screen for presence syncytial virus A B, adenovirus, rhinovirus, parainfluenza 1 4, influenza metapneumovirus, bocavirus, coronavirus OC43/229E NL63,...
Abstract Neuronal autophagy is essential for maintaining protein and organelle turnover, thereby safeguarding neuronal health. LC3, a central protein, exists in lipidated (LC3-II) non-lipidated (LC3-I) forms, both critical neurons due to their sensitivity metabolic proteostatic stress. To elucidate the specific roles of membrane-anchored LC3A/B post-mitotic neurons, we engineered deconjugases with enhanced selectivity LC3. By modifying LC3-interacting regions (LIRs) at deconjugase termini,...
The rapid aging population and low birth rates in rural areas of South Korea have led to severe depopulation a sharp decline the school-age population, posing significant challenges for these regions. proportion children decreased from 60.7% 1970s 16.6% 2022. This has exacerbated deterioration educational environment widened gap between urban areas. Such disparities accelerate outmigration students, hindering sustainable development communities. study aims address by examining current state...
A novel Gram-stain-negative, facultatively anaerobic, non-motile and coccus-shaped bacterium, strain C7(T), was isolated from the gut of butterfly Sasakia charonda. Strain C7(T) grew optimally at 20-25 °C, pH 7-8 with 1 % (w/v) NaCl. The negative for oxidase activity but positive catalase activity. 16S rRNA gene sequences Orbus hercynius CN3(T) shared 96.8 similarity. major fatty acids identified were C14 : 0, C16 C18 1ω7c summed feature 2 (comprising 0 3-OH/iso-C16 1). respiratory quinone...
A Gram-stain-negative, non-motile, aerobic, endospore forming and rod-shaped bacterium, designated strain L10(T), was isolated from marine sediment collected the South Korean coast. The organism grew optimally under conditions of 30 °C, 1 % (w/v) NaCl pH 6.0. It oxidase-negative catalase-positive. Phylogenetic analysis based on 16S rRNA gene sequences indicated that L10(T) associated with genus Paenibacillus most closely related to barcinonensis BP-23(T) (98.2 similarity). major fatty acids...
Strain LHWP2(T), a novel, aerobic, budding, motile and ovoid bacterium belonging to the phylum Planctomycetes, was isolated from dead ark clam (Scapharca broughtonii) south coast of Korea. LHWP2(T) grew optimally at 30 °C, in presence 4% (w/v) NaCl, pH 7. The predominant cellular fatty acids were C16:0, C18:1ω7c and/or C18:1ω6c (summed feature 8) C18:1ω9c. major isoprenoid quinone menaquinone-6 (MK-6). dominant polar lipid identified as phosphatidylglycerol. Phylogenetic analysis based on...
For the fermentation of vinegar using onion, acetic acid bacteria and yeast strains with high ability were screened. Among them, Saccharomyces cerevisiae 1026 was selected as a starter for ethanol production Acetobacter orientalis MAK88 producer. When two-stage onion performed at 28 °C, titratable acidity reached 4.80% 24 h fermentation. semi-continuous proceeded to charge-discharge consisting three cycles, content 4.35% 48 At this stage, efficiency, productivity, specific product formation...
Mammalian ATG8 proteins (mATG8s) are essential for selective autophagy because they recruit various with LC3- interacting region (LIR) motifs to autophagic membranes. The RavZ protein, secreted by Legionella pneumophila, and mammalian ATG4B possess functional LIR that participate in lipidated mATG8 deconjugation on comprises three at the N- Cterminal sides of its catalytic domain (CAD). This study demonstrated N-terminal side CAD involved membrane targeting substrate recognition, while motif...
A slightly halophilic, Gram-negative, strictly aerobic, non-motile rod, designated TW15(T), was isolated from an ark clam in South Korea. Growth occurred at 10-37 °C, with 1-5% (w/v) NaCl and pH 7.0-10.0. Optimal growth 25-30 2% 8.0. Strain TW15(T) exhibited both oxidase catalase activities. The major fatty acids of strain were summed feature 8 (consisting C(18:1)ω7c and/or C(18:1)ω6c) 11-methyl C(18:1)ω7c. predominant isoprenoid quinone ubiquinone-10 (Q-10). polar lipids comprised...
Abstract The ideal carbon dioxide (CO2) thickener would be an affordable, safe, water-insoluble additive that could dissolve in CO2 at typical wellhead and reservoir conditions during enhanced oil recovery (EOR) elevate the viscosity of to same value as oil. Further, not require heating or organic co-solvent achieve dissolution. A a transformative technology it eliminate unfavorable mobility ratios EOR reduce need for WAG. detailed history prior attempts thicken with either high molecular...