A5101808279- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Inflammatory Myopathies and Dermatomyositis
- Eosinophilic Disorders and Syndromes
- Medical Imaging and Pathology Studies
- Diet and metabolism studies
- Metabolomics and Mass Spectrometry Studies
- Ion channel regulation and function
- Respiratory viral infections research
- Influenza Virus Research Studies
- Systemic Sclerosis and Related Diseases
- Immune Cell Function and Interaction
- Genetics, Aging, and Longevity in Model Organisms
- Oral microbiology and periodontitis research
- Oral Health Pathology and Treatment
- Liver Diseases and Immunity
- Cancer, Hypoxia, and Metabolism
- Pneumocystis jirovecii pneumonia detection and treatment
- Renal Diseases and Glomerulopathies
- Adipose Tissue and Metabolism
- Neonatal Respiratory Health Research
- Pulmonary Hypertension Research and Treatments
- Customer churn and segmentation
- Hepatocellular Carcinoma Treatment and Prognosis
- Diet, Metabolism, and Disease
- Sperm and Testicular Function
Nanjing Drum Tower Hospital
2013-2024
Nanjing Medical University
2022-2023
Institute of Computing Technology
2023
Chinese Academy of Sciences
2023
Longgang Central Hospital
2022-2023
Nanjing University
2022
Guangdong Medical College
2019-2022
Shanxi Medical University
2018
First Hospital of Shanxi Medical University
2018
Jinan Military General Hospital
2017
Idiopathic pulmonary fibrosis (IPF) is a progressive, eventually fatal disease. IPF characterized by excessive accumulation of the extracellular matrix (ECM) in alveolar parenchyma and progressive lung scarring. The pathogenesis whether ECM involved process remain unknown.To identify potential treatment target associated proteins that may be development IPF, we employed isobaric tag for relative absolute quantitation (iTRAQ) combined liquid chromatography-tandem mass spectrometry (LC-MS/MS)...
Idiopathic pulmonary fibrosis (IPF) is an aging-associated disease with poor prognosis. The mechanisms underlying the role of alveolar epithelial cell (AEC) senescence in IPF remain poorly understood. We aimed to investigate if PTEN/Akt activates AEC induce fibrosis. investigated association between and cellular lung tissues from patients. As a result, decreased PTEN activated Akt pathway were found AECs fibrotic detected by immunohistochemistry (IHC) immunofluorescence (IF). Increased...
Hepatocellular carcinoma (HCC) frequently relapses after minimally invasive treatment. This study aimed to observe the influencing factors of different recurrence patterns radiofrequency ablation (RFA) for treatment recurrence.The medical records HCC patients who underwent RFA between January 2010 and 2019 were retrospectively reviewed. is classified into three types: local tumour progression (LTP), intrahepatic distant metastasis, extrahepatic metastasis. Risk factors, overall survival...
Male infertility is considered a common health problem, and non-obstructive azoospermia with unclear pathogenesis one of the most challenging tasks for clinicians. The objective this study was to investigate differential serum metabolic pattern in azoospermic men determine potential biomarkers related spermatogenic dysfunction. Serum samples from patients (n = 22) healthy controls 31) were examined using high-performance liquid chromatography-tandem mass spectrometry (HPLC-MS/MS)....
Abstract Objectives In the present study, we aimed to assess clinical significance of cytokeratin 19 fragment (CYFRA21-1) in patients with anti-melanoma differentiation-associated gene 5 (MDA5) antibody-positive DM-interstitial lung disease (MDA5-DM-ILD). Methods A total 73 MDA5-DM-ILD were retrospectively analysed this work. Their characteristics, including manifestations, laboratory findings, peripheral blood lymphocyte subsets and function, compared between acute/subacute interstitial...
Metabolomics screening revealed the alteration of fatty acid oxidation in hearts diabetic mice after SGLT2i treatment.
The oral microbiota are closely related to human health. Nonetheless, the best of our knowledge, their relationship with membranous nephropathy (MN) remains unstudied. saliva collected from 22 patients MN and 15 healthy controls were analyzed by next‑generation sequencing, bioinformatics analysis 16S ribosomal RNA gene was subsequently carried out. Chao1 Shannon indices in higher than those controls. Analysis similarities revealed that patient group significantly different At genus level,...
Background Anti-melanoma differentiation-associated gene 5 antibody-positive dermatomyositis with interstitial lung disease (anti-MDA5 DM-ILD) is a high mortality. We sought to develop an effective and convenient prediction tool estimate mortality risk in patients anti-MDA5 DM-ILD inform clinical decision-making early. Methods This prognostic study included Asian hospitalized at the Nanjing Drum Hospital from December 2016 2020. Candidate laboratory indicators were retrospectively collected....
Microbiota plays an important role in immunoglobulin A (IgA) nephropathy (IgAN); however, the pathogenesis, early diagnosis, and treatment of IgAN remain unclear. The aim present study was to develop a preliminary model based on saliva‑specific microbes clinical indicators facilitate diagnosis obtain insights into its treatment. microbial profile saliva 28 patients 25 healthy control subjects investigated using high‑throughput sequencing bioinformatics analyses V4 region 16S rRNA genes. did...
Pulmonary alveolar proteinosis (PAP) is a rare disorder characterized by the accumulation of excessive surfactant lipids and proteins in macrophages alveoli. Oral statin therapy novel treatment for PAP with hypercholesterolemia. However, this has never been described patient without Here, we present case successful atorvastatin possibly unclassified hypercholesterolemia who responded poorly to whole lung lavage inhaled granulocyte-macrophage colony-stimulating factor. After 18 months...
Abstract: Acute fibrinous and organizing pneumonia (AFOP) is an unusual pathological pattern which characterized by intra-alveolar deposition of fibrin (fibrin ball) in a scattered distribution, the diagnosis plays irreplaceable role diagnosis. Most Patients cannot confirm etiology, till now, known etiology included connective tissue disease, infection, environmental occupational exposure, drugs, organ transplant, tumor. It can be divided into acute subacute subtype according to extent...
Objectives Risk prediction for patients with polymyositis/dermatomyositis-associated interstitial lung disease (PM/DM-ILD) is challenging due to heterogeneity in the course. We aimed develop a mortality risk model PM/DM-ILD. Methods This prognostic study analysed PM/DM-ILD admitted Nanjing Drum Hospital from 2016 2021. The primary outcome was within 1 year. used least absolute shrinkage and selection operator (LASSO) logistic regression identify predictive laboratory indicators. These...
<b>Objective:</b> To test the impact of pirfenidone and nintedanib treatment on lung histopathology markers senescence in patients with idiopathic pulmonary fibrosis (IPF). <b>Methods:</b> We collected tissue from IPF at time transplantation. Histopathologic changes were quantified using a blinded scoring method. Proteins associated tissues by immunoblot immunostaining. <b>Results:</b> quantification showed similar amounts dense collagen fibrosis, fibroblast foci, or alveolar macrophages...
Objectives: To evaluate the use of cyclophosphamide or cyclosporin-A in anti-synthetase syndrome-related interstitial lung disease (ASS-ILD).Methods: Patients diagnosed with ASS-ILD at Nanjing Drum Tower Hospital from Feb 2015 to Jun 2020 treated prednisone plus were included. Clinical information and treatment course collected.Results: 25 patients who had received 21 treatment. Both associated improved forced vital capacity predicted (FVC% predicted) (0.39 per month, 0.37 month) diffusion...
Background: Idiopathic pulmonary fibrosis (IPF) is a chronic and progressive interstitial lung disease characterized by fibrotic remodeling scarring. Until now, there no effective drug for IPF patients. Mesenchymal stromal cells (MSCs) have shown potential treating but the heterogeneity impacts their therapeutic efficacy.Methods: We screened superior candidate seeding fully exploiting of human MSCs derived from eight tissues specifically targeting to critical pathogenic mechanism through...
Given that transbronchial lung cryobiopsy (TBLC) is recommended as a surrogate for surgical biopsy (SLB) in the diagnosis of interstitial disease (ILD), few studies have evaluated optimal number sample or impact radiologic pattern on diagnostic yield and postoperative complications. This study aimed to investigate how patterns affect We conducted multi-center retrospective including 334 consecutive ILD patients who underwent TBLC. The yields complications was assessed. Logistic regression...