A5023767939- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Advanced Electron Microscopy Techniques and Applications
- Electron and X-Ray Spectroscopy Techniques
- Inflammatory Myopathies and Dermatomyositis
- Molecular Biology Techniques and Applications
- Sarcoidosis and Beryllium Toxicity Research
- Occupational and environmental lung diseases
- Cell Image Analysis Techniques
- Pneumonia and Respiratory Infections
- Medical Imaging and Pathology Studies
- Systemic Sclerosis and Related Diseases
- Neuroscience and Neuropharmacology Research
- Cancer-related molecular mechanisms research
- Fungal Infections and Studies
- Cancer Cells and Metastasis
- Antifungal resistance and susceptibility
- Eosinophilic Disorders and Syndromes
- Simulation Techniques and Applications
- Neuroinflammation and Neurodegeneration Mechanisms
- Ear Surgery and Otitis Media
- Barrier Structure and Function Studies
- Cancer, Lipids, and Metabolism
- Peptidase Inhibition and Analysis
- RNA modifications and cancer
- Proteoglycans and glycosaminoglycans research
Nanjing Drum Tower Hospital
2015-2025
Universitätsmedizin Greifswald
2023-2024
Technical University of Munich
2024
German Center for Neurodegenerative Diseases
2023-2024
Ludwig-Maximilians-Universität München
2024
Normandie Université
2024
Cyceron
2024
Physiopathologie et imagerie des troubles neurologiques
2024
LMU Klinikum
2024
Inserm
2024
Abstract Understanding the complexity of cellular function within a tissue necessitates combination multiple phenotypic readouts. Here, we developed method that links spatially-resolved gene expression single cells with their ultrastructural morphology by integrating multiplexed error-robust fluorescence in situ hybridization (MERFISH) and large area volume electron microscopy (EM) on adjacent sections. Using this method, characterized transcriptional responses glial infiltrating T-cells...
The efficacy of tofacitinib (TOF) in the early diagnosis melanoma differentiation-associated gene 5 (MDA5)-related interstitial lung disease (ILD) has been described. However, whether TOF exposure is associated with a reduced 1-year mortality rate remains undetermined.Patients diagnosed MDA5-ILD receiving or tacrolimus (TAC) treatment were included. A Cox proportional hazards model, which was adjusted for age, sex, smoking history, anti-MDA5 antibody titers, and concurrent use other...
Idiopathic pulmonary fibrosis (IPF) is a progressive fibrotic lung disease with poor prognosis, nomogram model for its prognosis and acute exacerbation was constructed. Two hundred sixty eight patients IPF were grouped different severity according to area, serum Club cell secretory protein 16(CC16) compared between these groups. All randomly divided into training testing sets. COX regression LASSO algorithm used screen featured characteristics. Then models constructed, ROC curve, calibration...
Cryptogenic organizing pneumonia (COP) is characterized by good response to corticosteroids, but frequent relapses after reduction or cessation of treatment are noted. The incidence, risk factors relapse, and long-term outcomes patients with COP remain undetermined. Patients from September 2010 December 2017 were enrolled. Hospital office records used as data sources. Clinical information, lab examinations, chest radiographs, courses, follow-up collected. Relapse group was defined worsening...
Due to high metastasis and recurrence rate. Recent studies indicated that epithelial-to-mesenchymal transition (EMT) was involved in the progression cancer. Some reports also indicate HS3ST3B1 played a role angiogenesis proliferation of cancer cells. In this study, we aim investigate its non-small cell lung (NSCLC) .All lines were purchased from ATCC cultured our central lab. RT-PCR performed study expession tumors matched normal tissues. Western-blot used lines. We luciferase report system...
The prevalence of invasive pulmonary aspergillosis (IPA) among patients with interstitial lung disease (ILD) is steadily increasing, leading to high mortality. purpose this study analyze the clinical features and risk factors IPA in ILD. 353 hospitalized ILD admitted Nanjing Drum Tower Hospital from March 2023 April 2024 were enrolled. enrolled divided into group (proven probable IPA) non-IPA group, characteristics prognosis compared between two groups. Among ILD, 58 who suffered identified....
Abstract Introduction Albumin‐to‐Alkaline Phosphatase Ratio (AAPR), a novel developed prognostic index for cancers. Chemotherapy was the only method driver mutation‐negative advanced non‐small cell lung cancer (DANSCLC). Objectives To evaluate clinical significance of AAPR in these patients. Methods We retrospectively reviewed 167 DANSCLCs and 58 healthy controls. Associations clinicopathological characteristics survival analysis were conducted. Results Significantly decreased level...
Like other volume electron microscopy approaches, Automated Tape Collecting Ultramicrotomy (ATUM) enables imaging of serial sections deposited on thick plastic tapes by scanning (SEM). However, ATUM is unique enabling hierarchical and thus efficient screening for target structures as needed e.g., correlated light microscopy. SEM tape can only access the section surface, thereby limiting axial resolution to typical size cellular vesicles, an order magnitude lower than acquired xy resolution....
Idiopathic pulmonary fibrosis (IPF) is a debilitating condition, with life expectancy of 2 to 5 years after diagnosis. Pirfenidone drug that has been shown reduce the decline in forced vital capacity (FVC). We sought identify whether different patterns on high-resolution computed tomography (HRCT) have clinical effects through retrospective comparison baseline values and changes function tests (PFTs) treatment pirfenidone. retrospectively analyzed data from IPF patients treated pirfenidone...
Objectives Risk prediction for patients with polymyositis/dermatomyositis-associated interstitial lung disease (PM/DM-ILD) is challenging due to heterogeneity in the course. We aimed develop a mortality risk model PM/DM-ILD. Methods This prognostic study analysed PM/DM-ILD admitted Nanjing Drum Hospital from 2016 2021. The primary outcome was within 1 year. used least absolute shrinkage and selection operator (LASSO) logistic regression identify predictive laboratory indicators. These...
Like other volume electron microscopy approaches, Automated Tape Collecting Ultramicrotomy (ATUM) enables imaging of serial sections deposited on thick plastic tapes by scanning (SEM). ATUM is unique in enabling hierarchical and thus efficient screening for target structures, as needed correlative light microscopy. However, SEM tape can only access the section surface, thereby limiting axial resolution to typical size cellular vesicles with an order magnitude lower than acquired xy...
Like other volume electron microscopy approaches, automated tape-collecting ultramicrotomy (ATUM) enables imaging of serial sections deposited on thick plastic tapes by scanning (SEM). ATUM is unique in enabling hierarchical and thus efficient screening for target structures, as needed correlative light microscopy. However, SEM tape can only access the section surface, thereby limiting axial resolution to typical size cellular vesicles with an order magnitude lower than acquired xy...
<title>Abstract</title> Background The prevalence of invasive pulmonary aspergillosis (IPA) among patients with interstitial lung disease (ILD) is steadily increasing, leading to high mortality. purpose this study analyze the clinical features and risk factors IPA in ILD. Methods 353 hospitalized ILD admitted Nanjing Drum Tower Hospital from March 2023 April 2024 were enrolled. enrolled divided into group (proven probable IPA) non-IPA group, characteristics prognosis compared between two...