Hanyi Jiang

ORCID: 0009-0003-8532-5196
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About
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Research Areas
  • Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
  • Advanced Electron Microscopy Techniques and Applications
  • Electron and X-Ray Spectroscopy Techniques
  • Inflammatory Myopathies and Dermatomyositis
  • Molecular Biology Techniques and Applications
  • Sarcoidosis and Beryllium Toxicity Research
  • Occupational and environmental lung diseases
  • Cell Image Analysis Techniques
  • Pneumonia and Respiratory Infections
  • Medical Imaging and Pathology Studies
  • Systemic Sclerosis and Related Diseases
  • Neuroscience and Neuropharmacology Research
  • Cancer-related molecular mechanisms research
  • Fungal Infections and Studies
  • Cancer Cells and Metastasis
  • Antifungal resistance and susceptibility
  • Eosinophilic Disorders and Syndromes
  • Simulation Techniques and Applications
  • Neuroinflammation and Neurodegeneration Mechanisms
  • Ear Surgery and Otitis Media
  • Barrier Structure and Function Studies
  • Cancer, Lipids, and Metabolism
  • Peptidase Inhibition and Analysis
  • RNA modifications and cancer
  • Proteoglycans and glycosaminoglycans research

Nanjing Drum Tower Hospital
2015-2025

Universitätsmedizin Greifswald
2023-2024

Technical University of Munich
2024

German Center for Neurodegenerative Diseases
2023-2024

Ludwig-Maximilians-Universität München
2024

Normandie Université
2024

Cyceron
2024

Physiopathologie et imagerie des troubles neurologiques
2024

LMU Klinikum
2024

Inserm
2024

Abstract Understanding the complexity of cellular function within a tissue necessitates combination multiple phenotypic readouts. Here, we developed method that links spatially-resolved gene expression single cells with their ultrastructural morphology by integrating multiplexed error-robust fluorescence in situ hybridization (MERFISH) and large area volume electron microscopy (EM) on adjacent sections. Using this method, characterized transcriptional responses glial infiltrating T-cells...

10.1038/s41467-023-39447-9 article EN cc-by Nature Communications 2023-07-11

The efficacy of tofacitinib (TOF) in the early diagnosis melanoma differentiation-associated gene 5 (MDA5)-related interstitial lung disease (ILD) has been described. However, whether TOF exposure is associated with a reduced 1-year mortality rate remains undetermined.Patients diagnosed MDA5-ILD receiving or tacrolimus (TAC) treatment were included. A Cox proportional hazards model, which was adjusted for age, sex, smoking history, anti-MDA5 antibody titers, and concurrent use other...

10.3899/jrheum.220367 article EN The Journal of Rheumatology 2022-08-15

Idiopathic pulmonary fibrosis (IPF) is a progressive fibrotic lung disease with poor prognosis, nomogram model for its prognosis and acute exacerbation was constructed. Two hundred sixty eight patients IPF were grouped different severity according to area, serum Club cell secretory protein 16(CC16) compared between these groups. All randomly divided into training testing sets. COX regression LASSO algorithm used screen featured characteristics. Then models constructed, ROC curve, calibration...

10.1186/s40001-024-02256-x article EN cc-by-nc-nd European journal of medical research 2025-01-10

Cryptogenic organizing pneumonia (COP) is characterized by good response to corticosteroids, but frequent relapses after reduction or cessation of treatment are noted. The incidence, risk factors relapse, and long-term outcomes patients with COP remain undetermined. Patients from September 2010 December 2017 were enrolled. Hospital office records used as data sources. Clinical information, lab examinations, chest radiographs, courses, follow-up collected. Relapse group was defined worsening...

10.1177/1479973119853829 article EN cc-by-nc Chronic Respiratory Disease 2019-01-01

Due to high metastasis and recurrence rate. Recent studies indicated that epithelial-to-mesenchymal transition (EMT) was involved in the progression cancer. Some reports also indicate HS3ST3B1 played a role angiogenesis proliferation of cancer cells. In this study, we aim investigate its non-small cell lung (NSCLC) .All lines were purchased from ATCC cultured our central lab. RT-PCR performed study expession tumors matched normal tissues. Western-blot used lines. We luciferase report system...

10.4103/jcrt.jcrt_659_17 article EN Journal of Cancer Research and Therapeutics 2018-01-01

The prevalence of invasive pulmonary aspergillosis (IPA) among patients with interstitial lung disease (ILD) is steadily increasing, leading to high mortality. purpose this study analyze the clinical features and risk factors IPA in ILD. 353 hospitalized ILD admitted Nanjing Drum Tower Hospital from March 2023 April 2024 were enrolled. enrolled divided into group (proven probable IPA) non-IPA group, characteristics prognosis compared between two groups. Among ILD, 58 who suffered identified....

10.1186/s12890-024-03430-x article EN cc-by-nc-nd BMC Pulmonary Medicine 2024-12-04

Abstract Introduction Albumin‐to‐Alkaline Phosphatase Ratio (AAPR), a novel developed prognostic index for cancers. Chemotherapy was the only method driver mutation‐negative advanced non‐small cell lung cancer (DANSCLC). Objectives To evaluate clinical significance of AAPR in these patients. Methods We retrospectively reviewed 167 DANSCLCs and 58 healthy controls. Associations clinicopathological characteristics survival analysis were conducted. Results Significantly decreased level...

10.1111/crj.13339 article EN The Clinical Respiratory Journal 2021-02-10

Like other volume electron microscopy approaches, Automated Tape Collecting Ultramicrotomy (ATUM) enables imaging of serial sections deposited on thick plastic tapes by scanning (SEM). However, ATUM is unique enabling hierarchical and thus efficient screening for target structures as needed e.g., correlated light microscopy. SEM tape can only access the section surface, thereby limiting axial resolution to typical size cellular vesicles, an order magnitude lower than acquired xy resolution....

10.7554/elife.90565.1 preprint EN 2023-10-10

Idiopathic pulmonary fibrosis (IPF) is a debilitating condition, with life expectancy of 2 to 5 years after diagnosis. Pirfenidone drug that has been shown reduce the decline in forced vital capacity (FVC). We sought identify whether different patterns on high-resolution computed tomography (HRCT) have clinical effects through retrospective comparison baseline values and changes function tests (PFTs) treatment pirfenidone. retrospectively analyzed data from IPF patients treated pirfenidone...

10.1097/md.0000000000033722 article EN cc-by-nc Medicine 2023-05-12

Objectives Risk prediction for patients with polymyositis/dermatomyositis-associated interstitial lung disease (PM/DM-ILD) is challenging due to heterogeneity in the course. We aimed develop a mortality risk model PM/DM-ILD. Methods This prognostic study analysed PM/DM-ILD admitted Nanjing Drum Hospital from 2016 2021. The primary outcome was within 1 year. used least absolute shrinkage and selection operator (LASSO) logistic regression identify predictive laboratory indicators. These...

10.1136/rmdopen-2023-003850 article EN cc-by-nc RMD Open 2024-04-01

Like other volume electron microscopy approaches, Automated Tape Collecting Ultramicrotomy (ATUM) enables imaging of serial sections deposited on thick plastic tapes by scanning (SEM). ATUM is unique in enabling hierarchical and thus efficient screening for target structures, as needed correlative light microscopy. However, SEM tape can only access the section surface, thereby limiting axial resolution to typical size cellular vesicles with an order magnitude lower than acquired xy...

10.7554/elife.90565.2 preprint EN 2024-07-22

Like other volume electron microscopy approaches, automated tape-collecting ultramicrotomy (ATUM) enables imaging of serial sections deposited on thick plastic tapes by scanning (SEM). ATUM is unique in enabling hierarchical and thus efficient screening for target structures, as needed correlative light microscopy. However, SEM tape can only access the section surface, thereby limiting axial resolution to typical size cellular vesicles with an order magnitude lower than acquired xy...

10.7554/elife.90565.3 article EN cc-by eLife 2024-08-05

<title>Abstract</title> Background The prevalence of invasive pulmonary aspergillosis (IPA) among patients with interstitial lung disease (ILD) is steadily increasing, leading to high mortality. purpose this study analyze the clinical features and risk factors IPA in ILD. Methods 353 hospitalized ILD admitted Nanjing Drum Tower Hospital from March 2023 April 2024 were enrolled. enrolled divided into group (proven probable IPA) non-IPA group, characteristics prognosis compared between two...

10.21203/rs.3.rs-5069345/v1 preprint EN cc-by Research Square (Research Square) 2024-11-19
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