A5101664263- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Systemic Sclerosis and Related Diseases
- Eosinophilic Disorders and Syndromes
- Pancreatitis Pathology and Treatment
- Inflammatory Myopathies and Dermatomyositis
- Pancreatic and Hepatic Oncology Research
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Inflammatory Biomarkers in Disease Prognosis
- Genetic factors in colorectal cancer
- Ginseng Biological Effects and Applications
- Gastrointestinal disorders and treatments
- Appendicitis Diagnosis and Management
- Bacterial Identification and Susceptibility Testing
- Antimicrobial Resistance in Staphylococcus
- Medical Imaging and Pathology Studies
- Tuberous Sclerosis Complex Research
- Cardiac Imaging and Diagnostics
- Antibiotics Pharmacokinetics and Efficacy
- Cell death mechanisms and regulation
- Inflammasome and immune disorders
- Lung Cancer Treatments and Mutations
- Animal health and immunology
- Cancer, Hypoxia, and Metabolism
- Advanced X-ray and CT Imaging
- Chemokine receptors and signaling
Nanjing Drum Tower Hospital
2019-2025
Nanjing Medical University
2022-2025
Yunnan Provincial Department of Education
2018
First Affiliated Hospital of Nanchang University
2014-2017
Nanchang University
2014-2017
Air Force Medical University
2009-2015
Ewha Womans University
2004
Abstract Objectives In the present study, we aimed to assess prevalence and clinical significance of anti-Ro52 antibodies in a cohort patients with idiopathic inflammatory myopathy-associated interstitial lung disease (IIM-ILD) different myositis-specific autoantibodies (MSAs). Methods A 267 IIM-ILD patients, including 62 PM, 126 DM 79 clinically amyopathic (CADM) were retrospectively analysed this study. Clinical laboratory findings, pulmonary function tests (PFTs), HRCT patterns treatment...
Objectives: To compare the value of emergent triglyceride (TG)-lowering therapies between early high-volume hemofiltration (HVHF) and low–molecular-weight heparin (LMWH) combined with insulin (LMWH+insulin) as well their effects on outcomes hypertriglyceridemic pancreatitis (HTGP) patients. Methods: In this randomized controlled trial, 66 HTGP patients presenting within 3 days after onset symptoms from August 2011 to October 2013 were assigned randomly receive either HVHF or LMWH+insulin an...
Chronic pulmonary inflammation (CPI) gives rise to serious lung injuries in rheumatoid arthritis (RA) patients. However, the molecular mechanism underlying pathogenesis of RA-associated CPI remains little understood. Here we established a novel tree shrew-based collagen-induced (TsCIA) model study CPI. Our results showed that typical but not fibrosis developed pathologically TsCIA model. Furthermore, abnormal up-regulation chemokine CXCL10 was directly associated with damage. Specific...
Transbronchial lung cryobiopsy (TBLC) has been identified to be a new technique diagnosis interstitial disease (ILD). The study was conducted investigate the safety and diagnostic accuracy of TBLC contrast with transbronchial biosy (TBLB) in patients ILD. In cross-sectional comparative study, suspected ILD who underwent or TBLB were evaluated from June 2018 September 2022 Nanjing drum tower hospital. procedure details clinical multidisciplinary discussion (MDD) based on clinical,...
The purpose of this study was to clarify whether the current scoring systems and single serum markers used in pancreatitis remain applicable for early prediction infected pancreatic necrosis (IPN) severity mortality acute (AP) accordance with revised Atlanta determinant-based classifications.Demographic, clinical, laboratory data from 708 consecutive patients AP were prospectively collected between January 2011 December 2012. classified using classification systems. predictive accuracies...
To identify specific risk factors of vancomycin-induced nephrotoxicity in China, as the relationship between vancomycin therapy (dosing and trough concentration monitoring) has been subject critical debate.The cases 90 critically ill patients who received Xijing Hospital northwest China March 2014 January 2015 were reviewed retrospectively. Vancomycin dosing, blood serum concentration, other independent associated with evaluated a multivariable model.Among patients, 59 males; mean age was...
Objective: Vitamin D deficiency was associated with CTD-ILD and reduced lung function.We sought to confirm that lower level would be related shorter survival times.Results: The patients had (P<0.05).Among who have improved function after treatment, elevation of positively ΔFVC (%), ΔFEV1(%) ΔDLCO-SB (%).The median time high serum 25(OH)D significantly longer than the low group (16.5 months vs14.0 months, P=0.007).The identified as an independent prognostic factor a hazard ratio 0.869 (95% CI...
Abstract Introduction Explanation of the mechanism resistance to third‐generation epidermal growth factor receptor tyrosine kinase inhibitors (EGFR‐TKIs) and development a novel strategy for drug are imperative in EGFR‐TKIs‐resistant non‐small cell lung cancer (NSCLC). SPOCK1 was found be abnormally expressed various tumors including cancer, however, there no study focused on role EGFR‐TKIs resistant cells. Methods Results We investigated roles NSCLC with resistance. showed that upregulated...
Background Anti-melanoma differentiation-associated gene 5 antibody-positive dermatomyositis with interstitial lung disease (anti-MDA5 DM-ILD) is a high mortality. We sought to develop an effective and convenient prediction tool estimate mortality risk in patients anti-MDA5 DM-ILD inform clinical decision-making early. Methods This prognostic study included Asian hospitalized at the Nanjing Drum Hospital from December 2016 2020. Candidate laboratory indicators were retrospectively collected....
Objective. The aim of this study was to evaluate the diagnostic and prognostic value red blood cell distribution width (RDW) in patients with connective tissue disease-associated interstitial lung disease (CTD-ILD). Methods. We retrospectively reviewed 213 CTD-ILD 97 CTD without ILD from February 2017 2020. Hospital office records were used as data sources. followed up. Results. Patients had significantly higher RDW than those ( <math xmlns="http://www.w3.org/1998/Math/MathML" id="M1">...
Background and Objectives：The purpose of the present study was to investigate diagnostic accuracy coronary stenoses in patients with ischemic heart disease using multidetector CT angiography (MDCT) assessment artery disease. Subjects Methods：Forty-three (49-72yrs) undergoing conventional (CCA) were included this study. All premedicated oral propranolol, 40-80 mg, achieve an acceptable rate less than 65 bpm, 1hr before MDCT. arteries, including distal segments side branches, assessed respect...
Abstract Background Cystic airspace is an uncommon imaging manifestation involved in non-small lung cancer (NSCLC). Diffuse cystic lesion even rarer as pulmonary of NSCLC. In the present study, we reported a rare case NSCLC associated with progressive diffusion lesions misdiagnosed Pulmonary langerhans cell histocytosis (PLCH), finally diagnosed by transbronchial cryobiopsy (TBCB). Case presentation A 52-year-old woman was admitted to our hospital due cough and dyspnea. High-resolution...
Objectives Risk prediction for patients with polymyositis/dermatomyositis-associated interstitial lung disease (PM/DM-ILD) is challenging due to heterogeneity in the course. We aimed develop a mortality risk model PM/DM-ILD. Methods This prognostic study analysed PM/DM-ILD admitted Nanjing Drum Hospital from 2016 2021. The primary outcome was within 1 year. used least absolute shrinkage and selection operator (LASSO) logistic regression identify predictive laboratory indicators. These...
The purpose of the research is to construct theoretical framework physical fitness quotient, assessment system, and PFQ-based training mode. methodology includes PFQ-related theories, assessments, literature review consultancy. Result shows feasibility construction in particular, system for special force. It concluded that mode a trend
Abstract Fibrosing interstitial lung disease (ILD) can cause high mortality and sensitive evaluation of fibrosing ILD could be critical. The aim this study is to develop a scoring system predict prognosis ILD. 339 patients with were enrolled as derivation cohort. Cox multiple regression analysis indicated that smoking history (HR = 3.826, p 0.001), age(HR 1.043, 0.015), CEA(HR 1.059, 0.049),CYFRA21-1(HR 1.177, 0.004) DLCO% predicted 0.979, 0.032) independent prognostic factors for clinical...