A5101928885- Transplantation: Methods and Outcomes
- Mechanical Circulatory Support Devices
- Organ Transplantation Techniques and Outcomes
- Respiratory Support and Mechanisms
- Anesthesia and Neurotoxicity Research
- Cardiac Ischemia and Reperfusion
- Anesthesia and Sedative Agents
- Anesthesia and Pain Management
- Fuel Cells and Related Materials
- Autophagy in Disease and Therapy
- Intensive Care Unit Cognitive Disorders
- Immune cells in cancer
- Acupuncture Treatment Research Studies
- Therapeutic Uses of Natural Elements
- Pain Mechanisms and Treatments
- Cancer, Stress, Anesthesia, and Immune Response
- Psychosomatic Disorders and Their Treatments
- Respiratory viral infections research
- Diet, Metabolism, and Disease
- Pharmacological Effects of Natural Compounds
- Antibiotics Pharmacokinetics and Efficacy
- Inflammasome and immune disorders
- Nausea and vomiting management
- Liver Disease Diagnosis and Treatment
- Cardiac, Anesthesia and Surgical Outcomes
Wuxi No.2 People's Hospital
2024
Jiangnan University
2024
Nanjing Medical University
1990-2024
Wuxi People's Hospital
2010-2024
Soochow University
2019
Abstract Background Critical patients with the coronavirus disease 2019 (COVID-19), even those whose nucleic acid test results had turned negative and receiving maximal medical support, have been noted to progress irreversible fatal respiratory failure. Lung transplantation (LT) as sole therapy for end-stage pulmonary fibrosis related acute distress syndrome has considered ultimate rescue these patients. Methods From February 10 March 10, 2020, three male were urgently assessed listed...
Abstract Background Studies have provided some evidence that pain is a risk factor for postoperative delirium (POD). Therefore, we investigated the relationship between preoperative and POD after noncardiac surgery. Methods was assessed with Montreal Cognitive Assessment, cognition Mini-Mental State Examination. Plasma C-reactive protein (CRP) detected by enzyme-linked immunosorbent assay before Preoperative classified its duration surgery as chronic (lasting more than 1 month), acute less...
Background: A hallmark feature of pulmonary arterial hypertension (PAH) is the excessive proliferation artery smooth muscle cells (PASMCs) in arteries. The exact role C-X-C motif chemokine ligand 12 (CXCL12)/chemokine receptor type 7 (CXCR7) PASMCs remains unknown. Methods: In this study, we examined expression profile CXCL12/CXCR7 both hypoxic rats and PASMCs. 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) was used to measure level Enzyme-linked immunosorbent assay...
Objective: Despite the application of dexmedetomidine (DEX) as a perioperative adjuvant in local analgesia, exact analgesic mechanism underpinning chronic neuropathic pain (CNP) awaits our elucidation. Methods: We investigated molecular mechanisms anti-nociceptive effect DEX on mouse model induced by constriction injury (CCI). Results: administration significantly increased paw withdrawal latency (PWL) values 0.5 to 2 h post-injection CCI-induced CNP mice at day 5 21 versus dimethyl...
Background: Lung ischemia–reperfusion injury (LIRI) is among the complications observed after lung transplantation and associated with morbidity mortality. Preconditioning of donor before organ retrieval may improve quality transplantation. We investigated whether preconditioning metformin (Met) ameliorates LIRI Methods: Twenty Lewis rats were randomly divided into sham, LIRI, Met groups. The in groups received saline Met, respectively, via oral gavage. Subsequently, a was harvested kept...
Background: Lactic acidosis is often seen in lung transplantation (LTx). Postoperative lactate frequently associated with poor outcome postoperative and critically ill patients. Our aim was to evaluate the predictive value of peak levels within 72 h LTx for 30-day late mortality. Methods: We evaluated patients who underwent from January 2015 September 2017. All admitted were classified according level (PL) surgery: PL <5 mmol/L (Group 1); =5–10 2), >10 3). performed logistic regression...
TYPE: Case Report Publication TOPIC: Transplantation INTRODUCTION: Coronavirus disease 2019 (COVID-19) related severe acute respiratory distress syndrome (ARDS) cases have an extremely high mortality rate, even with the support of mechanical ventilation (MV) and extracorporeal membrane oxygenation (ECMO). This report provides initial experience bilateral lung transplantation (LT) as a salvage therapy for patients progressive deterioration function multiple negative nucleic acid tests...
Objective To evaluate the efficacy and safety of dexmedetomidine (Dex) used for postoperative intravenous analgesia in patients with large-area burn.Methods Forty 18-60 years old patients,undergoing escharectomy were randomly assigned into two groups 20 cases each.Group Ⅰ received patient-controlled analgesia(PCIA) fenmnyl,Group Ⅱ PCIA Dex fentanyl.Visual analogue scales (VAS) scores Ramsay at 4,8,24 h 48 after operation incidence nausea vomit,somnolence,bradycardia respiratory depression...
Objective To evaluate the effect of parecoxib on wound healing in early third degree burn mice. Methods Ninety ICR male mice, aged 6–8 weeks, weighing 20–25 g, were randomly divided into 3 groups (n= 10 each) using a random number table: group (B group); low-dose (LP high-dose (HP group). In LP and HP groups, at 4 h after Ⅲdegree model was established, 0.75 mg/kg 7.50 injected intraperitoneally, respectively, every 24 (administration times total). The equal volume normal saline 0.5 ml...
To investigate the risk factors of early death after lung transplantation in patients with idiopathic pulmonary fibrosis (IPF) complicated arterial hypertension (PAH).A retrospective cohort study was conducted. The clinical data 134 IPF and PAH who underwent at Wuxi People's Hospital Affiliated to Nanjing Medical University from January 2017 December 2020 were collected. donor's gender, age, duration mechanical ventilation, cold ischemia time, recipient's body mass index (BMI), smoking,...
Mechanical ventilation may cause ventilator-induced lung injury (VILI). Because elderly patients always have the respiratory insufficiency,they are more Vulnerable to VILI during general anesthesia. This paper reviews mechanism of ventilatorinduced in anesthesia and research progress application lung-protective mechanical strategies. Key words: General anesthesia; Elderly patients; Mechanical ventilation; Lung injury; Lung-protective
Background: Lung ischaemia‒reperfusion injury (LIRI) is associated with high rates of perioperative morbidity and mortality, sevoflurane can attenuate LIRI. However, the protective mechanism unclear.Methods: Sprague–Dawley (SD) rats BEAS-2B cells were applied in study. Animals subjected to administration 2.1% 30 min before onset left pulmonary artery reperfusion following 45 occlusion. Transcriptome sequencing was used analysed lung tissues. Autophagy inhibition(3-MA) Rac1-overexpression...
To summarize the strategy of using extracorporeal membrane oxygenation (ECMO) support during lung transplantation from 2 coronavirus disease 2019 (COVID-19) with end-stage respiratory failure.Two COVID-19 failure patients were admitted to Nanjing Medical University Affiliated Wuxi People's Hospital in March 2020. As homoeostasis and vital signs could not be maintained balance by conventional treatments, transplantations performed. Here, detail information about combined application...