A5103048810- Ultrasound Imaging and Elastography
- Salivary Gland Disorders and Functions
- Thyroid Cancer Diagnosis and Treatment
- Protease and Inhibitor Mechanisms
- Breast Lesions and Carcinomas
- Photoacoustic and Ultrasonic Imaging
- AI in cancer detection
- Ferroptosis and cancer prognosis
- Ovarian cancer diagnosis and treatment
- Dermatologic Treatments and Research
- Ultrasound and Hyperthermia Applications
- Systemic Sclerosis and Related Diseases
- Salivary Gland Tumors Diagnosis and Treatment
- Thyroid and Parathyroid Surgery
- Head and Neck Anomalies
- Circular RNAs in diseases
- Ultrasonics and Acoustic Wave Propagation
- Cancer Mechanisms and Therapy
- Dysphagia Assessment and Management
- Cell Adhesion Molecules Research
- Wound Healing and Treatments
- Radiomics and Machine Learning in Medical Imaging
- Antimicrobial Peptides and Activities
- Global Cancer Incidence and Screening
- Oral Health Pathology and Treatment
Sun Yat-sen Memorial Hospital
2015-2025
Sun Yat-sen University
2015-2025
Peking University
2020
Peking University People's Hospital
2020
We investigated the effect of angiotensin II (Ang II) on matrix metalloproteinase-1 (MMP-1)/tissue inhibitor (TIMP-1) balance in regulating collagen metabolism diabetic skin. Skin tissues from model were collected, and primary cultured fibroblasts treated with Ang receptor inhibitors before treatment. The type I (Coll I) III III) measured by histochemistry. expressions transforming growth factor-β (TGF-β), MMP-1, TIMP-1 propeptides types procollagens skin quantified using polymerase chain...
Breast lesions classified as BI-RADS-US 3 are probably benign and observation was recommended, while a considerable number of 4 were benign, resulting in excessive biopsies. We focus exclusively on hypothesize that improved diagnostic performance can be achieved by integrating real-time elastography (strain ratio) into the classification system. From April 2010 to September 2015, 1071 included final analysis. After conventional ultrasound examination, (2013) used evaluate lesions. Then...
Objective: Although a positive result of labial salivary gland biopsy (LSGB) is critical for the diagnosis Sjögren’s syndrome, rheumatologists prefer assessing non-invasive objective items and hope to learn predicted probability LSGB before referring patients with suspected syndrome receive biopsy. This study aimed explore predictive value combined B-mode ultrasonography (US) shear-wave elastography (SWE) examination on results. Methods: A derivation cohort later validation were recruited....
Although plain radiology is the primary method for assessing joint space width (JSW), it has poor sensitivity to change over time in regards determining longitudinal progression. We, therefore, developed a new ultrasound (US) measurement of knee JSW and aimed provide monitoring future.A multicenter study was promoted by Professional Committee Musculoskeletal Ultrasound, Ultrasound Society, Chinese Medical Doctor Association. US specimens determined landmarks ultrasonic JSW. The 1,272...
Abstract Background: Ovarian cancer (OV) is the fifth leading cause of death among women. Growing evidence supports a key role tumor microenvironment in growth, progression, and metastasis OV. However, prognostic effects gene expression signatures associated with OV have not been well established. This study was aimed at applying Estimation STromal Immune cells MAlignant Tumor tissues using Expression data (ESTIMATE) algorithm to identify tumor-microenvironment-associated genes that predict...
Background: Matrix metalloproteinases (MMPs) degrade extracellular matrix components. Increased MMP-9 content in diabetic skin contributes to vulnerability and refractory foot ulcers. To identify ways decrease levels skin, inhibition of expression dermal fibroblasts using small interfering RNA was investigated vitro. Methods: A full-thickness wound created on the midback streptozotocin-induced rats; biopsies were performed 3 days later. Skin observed by immunohistochemical analysis. Dermal...
To investigate the application value of The American College Radiology (ACR) Thyroid Imaging Reporting and Data System (TI-RADS) category combined with other ultrasound features nodules in distinguishing follicular thyroid carcinoma (FTC) from adenoma (FTA).We collected retrospectively analyzed clinical data for 118 459 patients FTCs FTAs, respectively, at our hospital. Next, we used ACR TI-RADS classification to distinguish FTC FTA. Multivariate Logistic regression was screen independent...
OBJECTIVE. The aim of this study was to evaluate the value shear wave elastography (SWE) in Graves disease (GD) and identify potential factors influencing thyroid stiffness. MATERIALS AND METHODS. A total 207 subjects were enrolled underwent SWE examination study, including 162 patients with GD 45 healthy volunteers normal thyroids, matched for age sex. For all subjects, five measurements elastic modulus values (SWE mean, minimum, maximum a 9-mm ROI) performed on each lobe, mean calculated....
Localized scleroderma (LS) is an autoimmune disease with sclerosis of the skin as main manifestation. Currently, there no specific treatment for LS. The effectiveness ablative fractional laser (AFL) therapy LS has been demonstrated in several studies. Combining Er:YAG topical methotrexate may yield therapeutic benefits patients To compare efficacy and safety AFL-assisted delivery adults LS, we randomly divided into AFL group laser-assisted (AFL+MTX) group. Laser assisted drug were given...
Our aim was to develop an ultrasonographic scoring model for staging hypofunction of salivary gland (SG) in patients suffering from Sjögren's disease (SjD).
Background: Heterogeneity is a major obstacle to developing effective treatments for patients with Sjögren’s syndrome (SjS). We aimed develop robust method stratify the secretory function of salivary glands (SG), exploiting distinguishing ability routine SG ultrasonography.Methods: A one-center derivation cohort 164 SjS and double-center validation 107 were enrolled. hypofunction was defined by whole flows. Bilateral parotid submandibular each participant examined B-mode ultrasonography....
Abstract Background Ovarian cancer (OV) is the fifth leading cause of death among females. Growing evidence supports a key role tumor microenvironment in growth, progress, and metastasis OV. However, impacts gene expression signatures related with OV on prognosis have not been well-established . This study aimed to apply ESTIMATE algorithm extract genes that predicted poor outcomes patients. Methods The profile samples were downloaded from Cancer Genome Atlas (TCGA) database. immune scores...