A5020043093- Chromatography in Natural Products
- Natural product bioactivities and synthesis
- Animal Virus Infections Studies
- Cancer-related molecular mechanisms research
- Food Chemistry and Fat Analysis
- Bioactive natural compounds
- Animal Nutrition and Physiology
- MicroRNA in disease regulation
- Nuclear Physics and Applications
- Circular RNAs in diseases
- Infant Nutrition and Health
- Viral gastroenteritis research and epidemiology
- Proteins in Food Systems
- RNA modifications and cancer
- Traditional Chinese Medicine Analysis
- Medicinal Plant Pharmacodynamics Research
- Insect and Pesticide Research
- Radiation Detection and Scintillator Technologies
- Animal Genetics and Reproduction
- Phytochemistry and Biological Activities
- Insect Pest Control Strategies
- S100 Proteins and Annexins
- Virology and Viral Diseases
- Analytical Chemistry and Chromatography
- Nuclear reactor physics and engineering
Tianjin Agricultural University
2020-2025
Guangzhou Medical University
2025
China Agricultural University
2013-2025
Second Affiliated Hospital of Guangzhou Medical University
2025
Ministry of Agriculture and Rural Affairs
2025
Lanzhou University of Technology
2024
Chinese Academy of Medical Sciences & Peking Union Medical College
2019-2024
Northeast Agricultural University
2021-2024
Tianjin Medical University
2024
Lanzhou University
2023
Abstract DEAD-box helicase 17 (DDX17) is a typical member of the family with transcriptional cofactor activity. Although DDX17 abundantly expressed in myocardium, its role heart not fully understood. We generated cardiomyocyte-specific Ddx17- knockout mice ( Ddx17 -cKO), transgenic -Tg), and various models cardiomyocyte injury failure (HF). downregulated myocardium mouse injury. Cardiomyocyte-specific promotes autophagic flux blockage apoptosis, leading to progressive cardiac dysfunction,...
The primary objective of the present study was to investigate effectiveness ultrasonic treatment time on particle size, molecular weight, microstructure and solubility milk fat globule membrane (rich in phospholipid, MPL) protein concentrate (MPC). mimicking human emulsions were prepared using modified proteins compound vegetable oil structural, emulsifying properties encapsulation efficiency evaluated. After treatment, cavitation caused size decreased structure change both MPL MPC,...
Saccharomyces cerevisiae is one of the important species traditional fermented foods and beverages. However, incorporating non-Saccharomyces in fermentation process a promising strategy to improve organoleptic profile. In this study, we assessed potential wild Pichia kluyveri strain (PKL) augment aromatic profile beer brewing while maintaining high attenuation through inoculation with var. diastaticus yeast (SY) both simultaneous (SI-PKL/SY) sequential (SE-3-PKL/SY) approaches. The...
The usage of doxorubicin is hampered by its life-threatening cardiotoxicity in clinical practice. Dexrazoxane the only cardioprotective medicine approved FDA for preventing doxorubicin-induced cardiac toxicity. Nevertheless, mechanism dexrazoxane incompletely understood. aim our study to investigate possible molecular against cardiotoxicity. We established a mouse and cardiomyocyte injury model. Male C57BL/6J mice were randomly distributed into control group (Con), treatment (DOX), plus...
The stability and structure of fat globules are crucial factors affecting the in infant formulas their inherent digestibility absorption infants. Thus, study mimicking milk globule (MFG) emulsions can provide a foundation for optimization fats formulas. This examined effects ratio egg yolk lecithin (EYL) to membrane (MFGM) material on emulsions. results show 1:1 EYL MFGM led an emulsion with highest encapsulation rate (90.07 ± 1.03%) physical stability, larger particle size (1.514 0.043 μm),...
Porcine reproductive and respiratory syndrome virus (PRRSV) is an important pathogen that causes huge economic losses to the swine industry worldwide. Here, a novel variant of PRRSV strain named TJnh2021 was isolated from nursery piglets with morbidity rate (75%) mortality (40%) in Tianjin Province China 2021. Phylogenetic molecular evolutionary analyses revealed highly similar NADC34-like (lineage 1.5, North America 2014) ORF1ab-ORF2 ORF6-ORF7 coding regions, as well QYYZ-like 3, 2010)...
A method of ultrasonic-assisted extraction followed by high-speed countercurrent chromatography was established for the and isolation three flavonoid glycosides, i.e. rutin, narcissin, nicotiflorin from Flos Sophorae Immaturus. The effects factors main compound (rutin) Immaturus were optimized using Box-Behnken design combined with response surface methodology. optimum conditions determined as ultrasonic power 83% (600 W), solvent-to-material ratio 56:1, methanol concentration 82% v/v, time...
Volatile components from Exocarpium Citri Grandis (ECG) were, respectively, extracted by three methods, that is, steam distillation (SD), headspace solid-phase microextraction (HS-SPME), and solvent extraction (SE). A total of 81 compounds were identified gas chromatography-mass spectrometry including 77 56 48 (SE) compounds, respectively. Despite the method, terpenes (39.98~57.81%) main volatile ECG, mainly germacrene-D, limonene, 2,6,8,10,14-hexadecapentaene, 2,6,11,15-tetramethyl-,...
Lipid digestion characteristics in human, bovine, and caprine milk were investigated using an infant vitro model. Our results suggested that particle size bovine increased initially then decreased over time, whereas the human continuously decreased. The lipolysis degree of (86.8%) was higher than (80.2%) (82.7%) (P < 0.05). Compared to milk, released unsaturated fatty acids lower SFAs. In addition, 12 84 glyceride species significantly different between during gastrointestinal Another 13 92...
Despite its rarity, testicular germ cell tumor (TGCT) is commonly diagnosed in young males aged 20-40. In recent years, the global prevalence of TGCT has gradually increased, with 12-30% patients experiencing relapse and metastasis. However, there are currently no reliable biomarkers for accurately predicting prognosis patients. Therefore, identifying novel risk stratification an immediate priority. Using samples from multiple centers, we identified a prognostic biomarker (SMAD family member...
Due to the heterogeneity and complex classification of testicular germ cell tumors (TGCTs), prognostic evaluation therapeutic targets remain unclear. Therefore, identifying a novel biomarker comprehensively assess TGCT prognosis immunotherapy response is crucial. We collected data from 457 patient samples 12 normal across six cohorts. Differential expression analysis combined with univariate Cox regression identified markers for TGCT. Multivariate survival further evaluated value...
This study aimed to investigate the effects of different supplemental amounts dandelion flavonoid extracts (DFE) in diets on nutrients chicken, slaughtering performance, blood biochemical indexes and antioxidant capacity spent laying hens. A total 180 560-day-old Hy-Line Brown hens were randomly divided into five groups. The control group was fed basal diet, while experimental groups supplemented with DFE at levels 1000, 2000, 4000, 8000 mg/kg (as T1, T2, T3, T4 group) respectively....
Phyllosticta fragaricola-induced angular leaf spot causes substantial economic losses in global strawberry production, necessitating advanced severity assessment methods. This study proposed a dual-phase grading framework integrating deep learning and computer vision. The enhanced You Only Look Once version 11 (YOLOv11) architecture incorporated Content-Aware ReAssembly of FEatures (CARAFE) module for improved feature upsampling squeeze-and-excitation (SE) attention mechanism channel-wise...
In the current study, we investigate changes in CD4+CD25+ cells chickens during infectious bursal disease virus (IBDV) infection. The percentage of lymph organs, e.g., thymus, spleen, bursa Fabricius and peripheral blood, first 1–5 days post infection (dpi) was assessed by flow cytometry. data revealed a remarkable decrease thymus from 1 to 5 dpi spleen early An increase among blood lymphocytes observed two IBDV Additionally, infiltrated along with CD4+ after Quantitative reverse...
Chronic hypertension, valvular heart disease, and infarction cause cardiac remodeling potentially lead to a series of pathological structural changes in the left ventricular myocardium progressive decrease function. Angiotensin II (AngII) plays key role onset development remodeling. Many microRNAs (miRNAs), including miR-154-5p, may be involved remolding, but underlying molecular mechanisms remain unclear. We aimed characterize function miR-154-5p reveal its induced by AngII. First,...
Tribolium castaneum is one of the most harmful storage pests in world. The aim this study was to determine chemical composition, repellent, and contact activities Moutan cortex essential oil against insect pest. In addition, effects were examined on expressions three major detoxifying enzyme genes T. castaneum. Four components identified by gas chromatography-mass spectrometry (GC-MS), which predominantly paeonol (99.13%). Paeonol exerted significant repellent activity castaneum, more potent...
Citri Reticulatae Pericarpium is the dried mature pericarp of Citrus reticulata Blanco which can be divided into "Chenpi" and "Guangchenpi." "Guangchenpi" genuine Chinese medicinal material in Xinhui, Guangdong province; based on greatest quality least amount, it most expensive among others. Hesperidin used as marker to identify described Pharmacopoeia 2010. However, both contain hesperidin so that impossible differentiate them by measuring hesperidin.Our study aims develop an efficient...