A5100434674- Liver Disease Diagnosis and Treatment
- Hepatocellular Carcinoma Treatment and Prognosis
- Cancer, Lipids, and Metabolism
- Cancer Immunotherapy and Biomarkers
- Ferroptosis and cancer prognosis
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Hepatitis B Virus Studies
- Pancreatic and Hepatic Oncology Research
- Cancer Mechanisms and Therapy
- Gallbladder and Bile Duct Disorders
- Inflammatory Biomarkers in Disease Prognosis
- Hepatitis C virus research
- Immune cells in cancer
- Musculoskeletal pain and rehabilitation
- Bone fractures and treatments
- Gastrointestinal disorders and treatments
- Liver Disease and Transplantation
- Peptidase Inhibition and Analysis
- Gastrointestinal Tumor Research and Treatment
- Urologic and reproductive health conditions
- Intestinal Malrotation and Obstruction Disorders
- Pediatric Urology and Nephrology Studies
- Bladder and Urothelial Cancer Treatments
- Cancer, Hypoxia, and Metabolism
- Kidney Stones and Urolithiasis Treatments
Tianjin Medical University Cancer Institute and Hospital
2024
Air Force General Hospital PLA
2024
Zhongnan Hospital of Wuhan University
2024
Wuhan University
2024
Army Medical University
2018-2024
Southwest Hospital
2024
Qilu Hospital of Shandong University
2014-2023
Second Affiliated Hospital of Nanchang University
2023
Nanchang University
2023
Shandong University
2013-2023
Heparin-binding epidermal growth factor (HB-EGF), a member of the family, plays pivotal role in progression several malignancies, but its and regulatory mechanisms hepatocellular carcinoma (HCC) remain obscure. Here, we report that transmembrane protease serine 4 (TMPRSS4) significantly enhanced expression proteolytic cleavage HB-EGF to promote angiogenesis HCC progression.A mechanistic analysis revealed TMPRSS4 not only increased transcriptional translational levels precursor, also promoted...
Abstract Background & Aims Elevation of high‐mannose glycans is a common feature malignant cells and has been suggested to be the basis for alternative cancer therapy several years. Here we want investigate antitumour effect pseudomonas aeruginosa‐mannosesensitive haemagglutinin ( PA ‐ MSHA ), genetically engineered heat‐inactivated strain with mannose‐sensitive binding activity, on hepatocellular carcinoma HCC ). Methods Tumourigenicity metastatic potentials were studied after treatment...
Abstract TMPRSS4 (Transmembrane protease serine 4) is up-regulated in a broad spectrum of cancers. However, little known about the biological effects on hepatocellular carcinoma (HCC) and related mechanisms. In present study, we found that overexpression significantly promoted invasion, migration, adhesion metastasis HCC. Further more, induced EMT HCC, which was mediated via snail slug as result Raf/MEK/ERK1/2 activation inhibition ERK1/2 by its inhibitor associated with reduced cell...
Background L-carnitine therapy for idiopathic sperm abnormalities exhibits variable effectiveness, and currently, there are no established criteria to predict patient response. This study investigated correlations between seminal plasma markers semen parameters identify biomarkers that can guide indications in patients with abnormalities. Methods A retrospective review was conducted on 223 male oligoasthenoteratospermia, who sought medical attention at our clinic January 2020 October 2022....
Abstract Certain metabolites in the tumor microenvironment (TME) can alter innate immunity. Here, it is shown how phosphomevalonate kinase (PMVK) allows hepatocellular carcinoma (HCC) cells to overcome anti‐tumor immunity mediated by CD8 + T cells. In HCCs, depletion of PMVK required facilitate cell activation and their subsequent suppression growth. Mechanistically, phosphorylates stabilizes glutamate decarboxylase 1 (GAD1), thus increasing synthesis γ‐aminobutyric acid (GABA), which...
This study aimed to develop a machine learning (ML)-assisted model capable of accurately predicting the probability biopsy Gleason grade group upgrading before making treatment decisions.We retrospectively collected data from prostate cancer (PCa) patients. Four ML-assisted models were developed 16 clinical features using logistic regression (LR), optimized by least absolute shrinkage and selection operator (Lasso) regularization (Lasso-LR), random forest (RF), support vector (SVM). The area...
Angiogenesis and immunosuppression have been described as closely related processes that can occur in parallel.As an inhibitor of matrix metalloproteinase, whether the level reversion-inducing cysteine-rich protein with Kazal motifs (RECK) hepatocellular carcinoma (HCC) reflects a link between angiogenesis is still unknown.We analyzed RNA expression, immune infiltration survival HCC from The Cancer Genome Atlas databases.Immune scores stromal were calculated based on ESTIMATE algorithm to...
Glucagon-like peptide-1 and its receptor agonist-exendin-4 (Ex-4) have been shown to provide beneficial effects for cardiovascular diseases. This study investigated the of Ex-4 on ischemia-induced ventricular arrhythmias in rats.Anesthetized male rats were once treated with (5 μg/kg, i.v.) 1 h before ischemia absence and/or presence 5-hydroxydecanoic acid (5-HD, 10 mg/kg, i.v., a specific inhibitor mitochondrial ATP-sensitive potassium [KATP] channels) which injected min ischemia. And then...
BRCA1-Associated Protein 1 (BAP1) is a deubiquitylase that found associated with multiprotein complexes regulate key cellular pathways, and subsequent researches have revealed BAP1 acts independently as tumor suppressor. Somatic mutations occur in various malignancies, but malignancies arising from mutation of suppressors unexplained tissue proclivity. Whether somatic or expression alteration hepatocellular carcinoma (HCC) influence carcinogenesis immunogenicity still unknown. In this study,...