A5100387659- Liver Disease Diagnosis and Treatment
- Ferroptosis and cancer prognosis
- Hepatitis C virus research
- Cancer, Lipids, and Metabolism
- Hepatocellular Carcinoma Treatment and Prognosis
- Hepatitis B Virus Studies
- Cancer Immunotherapy and Biomarkers
- Liver Disease and Transplantation
- RNA modifications and cancer
- Autophagy in Disease and Therapy
- Pneumonia and Respiratory Infections
- Nanoplatforms for cancer theranostics
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Tracheal and airway disorders
- Photodynamic Therapy Research Studies
- Congenital Heart Disease Studies
- Pancreatic and Hepatic Oncology Research
- Liver physiology and pathology
- Alcohol Consumption and Health Effects
- Influenza Virus Research Studies
- Aortic aneurysm repair treatments
- Inflammatory Biomarkers in Disease Prognosis
- Ubiquitin and proteasome pathways
- Herpesvirus Infections and Treatments
- Diet, Metabolism, and Disease
Capital Medical University
2010-2025
Qilu Hospital of Shandong University
2015-2025
Shenzhen Center for Disease Control and Prevention
2024-2025
Affiliated Hospital of Youjiang Medical University for Nationalities
2025
Hebei North University
2025
Beijing University of Chinese Medicine
2020-2025
Beijing Children’s Hospital
2009-2025
Beijing YouAn Hospital
2017-2024
Anhui Medical University
2022-2024
Nanjing Tech University
2022-2024
Skin and soft-tissue abscesses, a common problem among injection drug users (IDUs), result in serious morbidity for the patient costly hospitalizations incision drainage; however, there has been little etiologic or preventive epidemiologic research on this problem. We performed case-control study that enrolled 151 IDUs who had given new diagnosis of abscess requiring drainage (cases) 267 did not have other bacterial infection during previous year were stratum-matched to cases according age,...
Cardiac hypertrophy is an adaptive response to pressure, volume stress, and loss of contractile mass from prior infarction. Metabolic changes in cardiac include suppression fatty acid oxidation enhancement glucose utilization, which could result lipid accumulation the heart. SIRT3, a mitochondrial NAD+-dependent deacetylase, has been demonstrated play crucial role controlling acetylation status many enzymes participating energy metabolism. However, SIRT3 pathogenesis hypertrophy-related...
Berberine (BBR) is an isoquinoline alkaloid extracted from several commonly used Chinese herbs. Our previous studies demonstrated BBR-mediated alleviation of lung injury due to inflammation and decrease in the mortality mice with influenza viral pneumonia. The recent argument autophagy against inflammatory responses has aroused wide concerns. This study focuses on reactive oxygen species-Nod-like receptor protein 3 (ROS-NLRP3) pathway investigate whether BBR inhibits NLRP3 inflammasome...
Metabolic dysfunction-associated steatohepatitis (MASH) - previously described as nonalcoholic (NASH) is a major driver of liver fibrosis in humans, while key determinant all-cause mortality disease independent MASH occurrence. CCAAT/enhancer binding protein α (CEBPA), versatile ligand-independent transcriptional factor, has an important function myeloid cells, and under clinical evaluation for cancer therapy. CEBPA also expressed hepatocytes regulates glucolipid homeostasis; however, the...
Autophagy is closely associated with cerebral ischaemia/reperfusion injury, but the underlying mechanisms are unknown. We investigated whether Spautin-1 ameliorates injury by inhibiting autophagy and its derived pyroptosis involved in this process. explored mechanism of ischaemia/reperfusion. To answer these questions, healthy male Sprague-Dawley rats were exposed to middle artery occlusion for 60 minutes followed reperfusion 24 hours. found that increased expression levels...
Machine learning (ML) algorithms were used to identify a novel biological target for breast cancer and explored its relationship with the tumor microenvironment (TME) patient prognosis. The edgR package identified hub genes associated overall survival (OS) prognosis, which validated using public datasets. Of 149 up-regulated in tissues, three ML COL11A1 as gene. COL11A1was highly expressed samples poor positively correlated stromal score (r=0.49, p<0.001) ESTIMATE (r=0.29, TME....
Morbidity and mortality due to oral cancer in India are exacerbated by a lack of access effective treatments amongst medically underserved populations. We developed user-friendly low-cost, portable fibre-coupled LED system for photodynamic therapy (PDT) early lesions, using smartphone fluorescence imaging device treatment guidance, 3D printed fibreoptic attachments ergonomic intraoral light delivery.
Guangzhou reported its first laboratory-confirmed case of influenza A (H7N9) on January 10, 2014. total 25 cases were from the wave epidemic until April 8, The fatality rate was much higher than in previous reports. objective current work to describe clinical and epidemiological characteristics patients explore possible reasons for high rate.Clinical information regarding collected through review medical records field research. Data laboratory features, treatment, outcomes extracted.Of...
Alcoholic cirrhosis is an end-stage liver disease with impaired survival and often requires transplantation. Recent data suggests that receptor-interacting protein kinase-3- (RIPK3-) mediated necroptosis plays important role in alcoholic cirrhosis. Additionally, neutrophil infiltration the most characteristic pathologic hallmark of hepatitis. Whether RIPK3 level correlated or poor prognosis cirrhotic patients still unknown. We aimed to determine correlation patients. A total 20 subjected...
Angiotensin II (Ang II) participates in the pathogenesis of liver injury. Our previous publications reported that myeloid differentiation protein 2 (MD2) mediates Ang II-induced cardiac and kidney inflammation by directly binding to II. Thus, we hypothesize MD2 is critical Subcutaneous injections for 8 weeks were adopted build injury model. With a specific inhibitor L6H21 knockout mice, inhibition significantly mitigate fibrosis mice injected with To be more specific, functional pathological...
Herein, we report the screening of a large panel genes in series 80 fetuses with congenital heart defects (CHDs) and/or heterotaxy and no cytogenetic anomalies. There were 49 males (61%/39%), family history 28 cases (35%) parental consanguinity 77 (96%). All had complex CHD except one who midline anomalies while 52 (65%) addition to CHD. Altogether, 29 (36%) extracardiac extra-heterotaxy A pathogenic variant was found 10/80 (12.5%) higher percentage group (8/52 cases, 15%) compared...
AIM:To evaluate the efficacy of ursodeoxycholic acid (UDCA) as a chemotherapeutic agent for treatment hepatocellular carcinoma (HCC).METHODS: BALB/c nude mice were randomized into four groups 24 h before subcutaneous injection hepatocarcinoma BEL7402 cells suspended in phosphate buffered saline (PBS) right flank.The control group (n = 10) was fed standard diet while 10 each) daily supplemented with different concentrations UDCA (30, 50 and 70 mg/kg per day) 21 d.Tumor growth measured once...
Abstract Cross-country (XC) ski races involve a variety of formats, two different techniques and tracks with highly variable topography environmental conditions. In addition, XC skiing is major component both Nordic combined biathlon competitions. Research in this area, the laboratory field, encounters certain difficulties that may reduce reliability validity data obtained, as well complicate comparisons between studies. Here, 13 international experts propose specific guidelines designed to...