A5060301312- Cancer, Hypoxia, and Metabolism
- Metabolism, Diabetes, and Cancer
- Cancer-related Molecular Pathways
- RNA modifications and cancer
- Mitochondrial Function and Pathology
- Cardiovascular Function and Risk Factors
- Chronic Lymphocytic Leukemia Research
- Pluripotent Stem Cells Research
- Autophagy in Disease and Therapy
- RNA Research and Splicing
- CRISPR and Genetic Engineering
- interferon and immune responses
- Epigenetics and DNA Methylation
- Pancreatic and Hepatic Oncology Research
- Liver Disease Diagnosis and Treatment
- Renal and related cancers
- Ubiquitin and proteasome pathways
- Endoplasmic Reticulum Stress and Disease
- Tissue Engineering and Regenerative Medicine
- Kruppel-like factors research
- Microtubule and mitosis dynamics
- Liver physiology and pathology
- TGF-β signaling in diseases
- Liver Disease and Transplantation
- Cancer-related molecular mechanisms research
Jiangxi Normal University
2025
Cancer Institute (WIA)
2024
Center for Cancer Research
2019-2024
National Cancer Institute
2017-2023
National Institutes of Health
2017-2022
National Cancer Center
2022
Karlsruhe Institute of Technology
2015
Heidelberg University
2015
Lanzhou University
2011
Institute of Animal Sciences
2011
MDM4 is a promising target for cancer therapy, as it undetectable in most normal adult tissues but often upregulated cells to dampen p53 tumor-suppressor function. The mechanisms that underlie upregulation are largely unknown. Here, we have shown this key oncogenic event mainly depends on specific alternative splicing switch. We determined while nonsense-mediated, decay-targeted isoform of (MDM4-S) produced result exon 6 skipping, enhanced inclusion leads expression full-length large number...
Translation and transcription are frequently dysregulated in cancer. These two processes generally regulated by distinct sets of factors. The CBFB gene, which encodes a factor, has recently emerged as highly mutated driver variety human cancers including breast Here we report noncanonical role translation regulation. RNA immunoprecipitation followed deep sequencing (RIP-seq) reveals that cytoplasmic binds to hundreds transcripts regulates their translation. mRNAs via hnRNPK enhances through...
Metabolic dysfunction-associated steatohepatitis (MASH) - previously described as nonalcoholic (NASH) is a major driver of liver fibrosis in humans, while key determinant all-cause mortality disease independent MASH occurrence. CCAAT/enhancer binding protein α (CEBPA), versatile ligand-independent transcriptional factor, has an important function myeloid cells, and under clinical evaluation for cancer therapy. CEBPA also expressed hepatocytes regulates glucolipid homeostasis; however, the...
Non-alcoholic fatty liver disease (NAFLD), the most prevalent chronic illness, is characterized by hepatic steatosis. Exercise and probiotics can regulate gut microbiota to treat NAFLD; however, their combined effects mechanisms of gut-liver communication remain unclear. Inconsistent results on probiotic efficacy further warrant investigation. In this study, zebrafish fed a high-fat diet (HFD) for six weeks were subjected swimming exercise (HFDE), intervention (HFDP), or combination both...
Abstract Cancer stem cells (CSCs) are key drivers of metastasis and therapy resistance but have been challenging to visualize study in situ . Using a fluorescent CSC reporter, we observed very different population dynamics for CSCs nonCSCs during metastatic lung colonization breast cancer models. expansive self-renewal drives early lesion formation before switching maintenance mode balanced differentiation, whereupon nonCSC proliferation takes over as the main driver expansion. Mechanistic...
Understanding functional interactions between cancer mutations is an attractive strategy for discovering unappreciated pathways and developing new combination therapies to improve personalized treatment. However, distinguishing driver gene pairs from passenger remains challenging. Here, we designed integrated omics approach identify by leveraging genetic interaction analyses of top mutated breast genes the proteomics interactome data their encoded proteins. This identified that PIK3CA...
Abstract Since it was found that p53 is highly expressed in murine embryonic stem cells, remained a mystery whether active this cell type. We show significant part of localised the nucleus cells and majority nuclear bound to DNA. According its localisation, we alters transcriptional program cells. Nevertheless, anti-proliferative activity compromised control due, at least part, high amount MdmX present p53. Instead has differentiated controls transcription pro-proliferative genes including...
The CBFB gene is frequently mutated in several types of solid tumors. Emerging evidence suggests that a tumor suppressor breast cancer. However, our understanding the suppressive function remains incomplete. Here, we analyze genetic interactions between mutations and other highly genes human cancer datasets find TP53 are mutually exclusive, suggesting functional association p53. Integrated genomic studies reveal TAp73 common transcriptional target cooperates with p53 to maintain expression,...
The absence of prominent, actionable genetic alternations in osteosarcomas (OS) implies that transcriptional and epigenetic mechanisms significantly contribute to the progression this life-threatening form cancer. Therefore, identification potential events promote survival OS cells could be key devising targeted therapeutic approaches for OS. We have previously shown RUNX2 is a transcription factor (TF) essential cell survival. Unfortunately, network or circuitry regulated by still largely...
Induced pluripotent stem cells (iPSCs) hold great promises in cell therapy. However, the potential safety issues have dampened enthusiasm of their clinical development. One biggest concerns came from observations that genomic alterations exist iPSCs. Using next generation sequencing clonal skin fibroblasts and iPSC clones derived same fibroblasts, Dr. Liu his colleagues National Human Genome Research Institute, Institutes Health (NIH), USA, collaboration with Dunbar's group Heart, Lung,...
The chloride intracellular channel-4 (CLIC4) is one of the six highly conserved proteins in CLIC family that share high structural homology with GST-omega GST superfamily. While CLIC4 a multifunctional protein resides multiple cellular compartments, discovery its enzymatic glutaredoxin-like activity vitro suggested it could function as an antioxidant. Here, we found deleting from murine 6DT1 breast tumor cells using CRISPR enhanced accumulation reactive oxygen species (ROS) and sensitized to...
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