A5008111914- RNA modifications and cancer
- MicroRNA in disease regulation
- Cancer-related molecular mechanisms research
- Circular RNAs in diseases
- Cancer Genomics and Diagnostics
- Pancreatic and Hepatic Oncology Research
- Animal Virus Infections Studies
- Cancer-related gene regulation
- RNA Research and Splicing
- Cancer Immunotherapy and Biomarkers
- Hepatocellular Carcinoma Treatment and Prognosis
- Cancer Mechanisms and Therapy
- Cancer, Hypoxia, and Metabolism
- EFL/ESL Teaching and Learning
- Ubiquitin and proteasome pathways
- Microbial infections and disease research
- Biochemical effects in animals
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Pain Mechanisms and Treatments
- Health and Wellbeing Research
- Ferroptosis and cancer prognosis
- Extracellular vesicles in disease
- Phytochemistry and Biological Activities
- Single-cell and spatial transcriptomics
- Ion Channels and Receptors
Sichuan Agricultural University
2014-2025
Nantong University
2025
Shandong University of Traditional Chinese Medicine
2025
University of Electronic Science and Technology of China
2024
Eastern Hepatobiliary Surgery Hospital
2018-2024
Second Military Medical University
2018-2024
Nanjing Drum Tower Hospital
2024
Hohhot First Hospital
2024
China Medical University
2024
First Affiliated Hospital of Xi'an Jiaotong University
2024
Spatial transcriptome technique was applied to decipher the spatial architecture and TME characteristics of liver cancers.
Circular RNA (circRNA) possesses great pre-clinical diagnostic and therapeutic potentials in multiple cancers.It has been reported playing roles malignant behaviors including proliferation, migration, metastasis chemoresistance.However, the underlying correlation between circRNAs cancer stem cells (CSCs) not yet.Methods: circZKSCAN1 level was detected HCC tissue microarrays to clarify its prognostic values.Gain loss function experiments were applied investigate role of stemness.Bioinformatic...
Triple-negative breast cancer (TNBC) is a subtype of (BC) with the most aggressive phenotype and poor overall survival. Using bioinformatics tools, we identified LINC00908 encoding 60–aa polypeptide differentially expressed in TNBC tissues. We named this endogenously ASRPS (a small regulatory peptide STAT3). expression was down-regulated TNBCs associated showed that directly regulated by ERα, which responsible for differential down-regulation TNBCs. bound to STAT3 through coiled coil domain...
N6-methyladenosine (m6A) has been reported as an important mechanism of posttranscriptional regulation. Programmed death-ligand 1 (PD-L1) is a primary immune inhibitory molecule expressed on tumor cells that promotes evasion. Here we report ALKBH5 m6A demethylase orchestrates PD-L1 expression in intrahepatic cholangiocarcinoma (ICC). Regulation by was confirmed human ICC cell lines. Sequencing the methylome identified mRNA direct target modification whose levels were regulated ALKBH5....
Purpose This paper examines the impact and mechanism of China's digital inclusive finance on rural consumption upgrade. First, development upgrading household structure is to be theoretically analyzed empirically tested. Secondly, in terms heterogeneity analysis, it pays attention age users that influencing residents' developmental upgrade, which related issue intergenerational “digital gap”. Thirdly, promoting upgrade investigated. Finally, how promote role a demand level will showed....
The spatial heterogeneity of immune microenvironment in hepatocellular carcinoma (HCC) remains elusive. Here, a single-cell study involving 17 432 600 cells 39 matched HCC (T), nontumor (N), and leading-edge (L) specimens by mass cytometry is conducted. tumor-associated CD4/CD8 double-positive T (DPT) are found enriched L regions with synergetic expression PD-1/HLA-DR/ICOS/CD45RO exhibit higher level IFN-
Molecular heterogeneity of hepatobiliary tumor including intertumoral and intratumoral disparity always leads to drug resistance. Here, seven organoids are generated explore evolution via single-cell RNA sequencing. HCC272 with high status epithelia-mesenchymal transition proves broad-spectrum By examining the expression pattern cancer stem cells markers (e.g., PROM1, CD44, EPCAM), it is found that CD44 positive population may render resistance in HCC272. UMAP pseudo-time analysis identify...
Background & AimsLack of thorough knowledge about the complicated immune microenvironment (IM) within a variety liver metastases (LMs) leads to inappropriate treatment and unsatisfactory prognosis. We aimed characterize IM subtypes investigate potential mechanisms in LMs.MethodsMass cytometry was applied landscape primary cancers cohort. Transcriptomic whole-exome sequencing were used explore across distinct subtypes. Single-cell transcriptomic sequencing, multiplex fluorescent...
Despite considerable efforts to identify human liver cancer genomic alterations that might unveil druggable targets, the systematic translation of multiomics data remains challenging. Here, we report success in long-term culture 64 patient-derived hepatobiliary tumor organoids (PDHOs) from a Chinese population. A divergent response 265 metabolism- and epigenetics-related chemicals 36 anti-cancer drugs is observed. Integration whole genome, transcriptome, chromatin accessibility profiles,...
The current study examined the associations between specific Internet activities (online shopping, pornography use, social networking site and gaming), life satisfaction, mediating effects of loneliness depression for these associations. Participants were 5,215 students (2,303 male participants, Mage = 16.20 years; ranging in age from 10 to 23 years) various school types (546 elementary students, 1710 junior high 688 senior 2271 university students) who provided self-report data on...
Neoantigen-directed therapy lacks preclinical models recapitulating neoantigen characteristics of original tumors. It is urgent to develop a platform assess T cell response for screening. Here, immunogenic potential neoantigen-peptides tumor tissues and matched organoids (n = 27 pairs) are analyzed by Score tools with whole genome sequencing (WGS)-based human leukocyte antigen (HLA)-class-I algorithms. The comparisons between 9203 predicted from 2449 mutations 9991 ones 2637 demonstrate that...
Heparin-binding epidermal growth factor (HB-EGF), a member of the family, plays pivotal role in progression several malignancies, but its and regulatory mechanisms hepatocellular carcinoma (HCC) remain obscure. Here, we report that transmembrane protease serine 4 (TMPRSS4) significantly enhanced expression proteolytic cleavage HB-EGF to promote angiogenesis HCC progression.A mechanistic analysis revealed TMPRSS4 not only increased transcriptional translational levels precursor, also promoted...
Human-derived mesenchymal stromal cells have been shown to improve cognitive function following experimental stroke. The activity of exosomes has verified be comparable the therapeutic effects cells. However, derived from human umbilical cord stem (HUC-MSCs) (ExoCtrl) on post-stroke impairment (PSCI) rarely reported. Moreover, whether C-C chemokine receptor type 2 (CCR2)-overexpressing HUC-MSCs (ExoCCR2) can enhance PSCI and possible underlying mechanisms not studied.To investigate ExoCtrl...
Regardless of a customer’s social status, wealth, or country origin, Apple products have been notorious for establishing trends in regard to electronic devices. As 2019, China accounted 17% percent all sales. This has made possible large part due Chinese customers’ favorable image the brand and positive experience with products. study aimed examine impact experience, love, engagement on equity. The brand-love mediation role between engagement/brand equity was also explored. conceptual...
Creativity plays an irreplaceable role in economic and technological development. It seems that religion has a negative association with creativity. If it is true, how can we interpret the rapid development of human society religious believers comprising 81% global population? Based on datasets World Values Survey Global Index, this study examined effects different religions/denominations national creativity, moderation effect gross domestic product per capita (GDPpc) 87 countries. The...
Abstract Immunotherapy is a powerful therapeutic strategy for end-stage hepatocellular carcinoma (HCC). It well known that T cells, including CD8+PD-1+ play important roles involving tumor development. However, their underlying phenotypic and functional differences of cell subsets remain unclear. We constructed single-cell immune contexture approximate 20,000,000 cells from 15 pairs HCC non-tumor adjacent tissues 10 blood samples (including five HCCs healthy controls) by mass cytometry....
ABSTRACT Porcine deltacoronavirus (PDCoV) is an enteric pathogen that burdens the global pig industry and a public health concern. The development of effective antiviral therapies necessary for prevention control PDCoV, yet to date, there are few studies on therapeutic potential PDCoV-neutralizing antibodies. Here, we investigate novel monoclonal antibody (mAb 4A6) which targets PDCoV S1 protein effectively neutralizes both pre- post-attachment cells, with IC50 values 0.537 8.487 µg/mL,...