A5100428815- Effects and risks of endocrine disrupting chemicals
- Crystallization and Solubility Studies
- X-ray Diffraction in Crystallography
- Carcinogens and Genotoxicity Assessment
- Heavy Metal Exposure and Toxicity
- Animal testing and alternatives
- Trace Elements in Health
- Cancer Mechanisms and Therapy
- Infant Nutrition and Health
- Fatty Acid Research and Health
- Mycotoxins in Agriculture and Food
- Heavy metals in environment
- Nutrition, Genetics, and Disease
- Nutritional Studies and Diet
- Antioxidant Activity and Oxidative Stress
- Pharmacological Effects of Natural Compounds
- Birth, Development, and Health
- Metabolomics and Mass Spectrometry Studies
- Immunotoxicology and immune responses
- Air Quality and Health Impacts
- Gastric Cancer Management and Outcomes
- Gout, Hyperuricemia, Uric Acid
- Crystallography and molecular interactions
- Estrogen and related hormone effects
- Pregnancy and preeclampsia studies
Sichuan University
2016-2025
China-Japan Friendship Hospital
2025
The Fourth People's Hospital
2025
China National Center for Food Safety Risk Assessment
2014-2024
Wenzhou Medical University
2017-2024
Zhejiang Taizhou Hospital
2017-2024
Chongqing Medical University
2022-2024
Shanxi Medical University
2024
Tianjin Medical University General Hospital
2023
Tianjin Medical University
2023
Background Vessels encapsulating tumor cluster (VETC) is a critical prognostic factor and therapeutic predictor of hepatocellular carcinoma (HCC). However, noninvasive evaluation VETC remains challenging. Purpose To develop validate deep learning radiomic (DLR) model dynamic contrast‐enhanced MRI (DCE‐MRI) for the preoperative discrimination prognosis HCC. Study type Retrospective. Population A total 221 patients with histologically confirmed HCC stratified this cohort into training set ( n...
Abstract MDR1 is highly expressed in MDR A2780DX5 ovarian cancer cells, SGC7901R gastric cells and recurrent tumours. It pumps cytoplasmic agents out of leading to decreased drug accumulation making susceptible multidrug resistance. Here, we identified that miR‐495 was predicted target ABCB1 , which encodes protein MDR1. To reduce the efflux reverse overexpressed a mimic A2780DX transplanted tumours vivo . The results indicated expression above or suppressed subsequently decreased, cell...
Cadmium is a well-known hazardous pollutant that mainly comes from dietary, tobacco and occupational exposure, posing threat to kidney. However, there still lack of systematic study on metabolic pathways urinary biomarkers related its nephrotoxicity under cadmium exposure for both females males. In this study, mass spectrometry-based metabolomics investigation cohort 144 volunteers was conducted explore sex-specific alteration screen cadmium-induced nephrotoxicity. When the concentration...
Dietary exposure of cadmium (Cd) has not been studied in Southwest China. The objective the study was to determine pollution characteristics and contamination levels various agriculture products China conduct a comparison dietary assessment Cd polluted non-polluted areas. Results showed that mean contents rice were 0.53 0.52 mg/kg high-polluted low-polluted areas, respectively, with average value 0.03 control area. from vegetables selected non-occupational residents 113.10 μg/kg bodyweight...
A systematic review and meta-analysis was conducted in six databases from 1948 to 2015 assess the antioxidant activity of astaxanthin humans. Nine randomized controlled trials were included review. Results revealed a borderline significant effect between intervention control groups, with malondialdehyde-lowering for lipid peroxidation (p = 0.050). However, data here are insufficient. When compared baseline suggested that supplements significantly decreased plasma malondialdehyde {Standard...
Abstract Heavy metals exposure has been associated with liver dysfunction in recent reports, while the hepatoxicity of lead (Pb) and cadmium (Cd) well established. However, combined effects multi‐metal real‐world scenario on are still unclear. This cross‐sectional study examined associations between 10 biomarkers early injury multiple heavy levels. The levels metals/metalloid (magnesium [Mg], calcium [Ca], iron [Fe], zinc [Zn], arsenic [As], Cd, copper [Cu], Pb) were measured blood urinary...
Cumulative risk assessment is significant for evaluating the combined exposure to multiple substances, but its widespread acceptance and application have been limited due complexity of clarifying assessing actual exposure. In this study, we conducted a cumulative based on hazard-driven criteria evaluate co-exposure elemental contaminants in diet population Chongqing Municipality. The was calculated evaluated using Monte Carlo modeling modified Reference Point Index (mRPI) method....