A5101403374- Cancer, Lipids, and Metabolism
- Cancer, Hypoxia, and Metabolism
- Cancer-related molecular mechanisms research
- Metabolomics and Mass Spectrometry Studies
- Circular RNAs in diseases
- Marine and coastal plant biology
- RNA modifications and cancer
- Antibiotic Resistance in Bacteria
- MicroRNA in disease regulation
- Bioinformatics and Genomic Networks
- Sphingolipid Metabolism and Signaling
- Coastal wetland ecosystem dynamics
- Plant-derived Lignans Synthesis and Bioactivity
- Ubiquitin and proteasome pathways
- Cancer Diagnosis and Treatment
- Endoplasmic Reticulum Stress and Disease
- Ferroptosis and cancer prognosis
- Protein Tyrosine Phosphatases
- Gene expression and cancer classification
- Pluripotent Stem Cells Research
- RNA Research and Splicing
- Carbohydrate Chemistry and Synthesis
- Steroid Chemistry and Biochemistry
- Antibiotic Use and Resistance
- Bacterial biofilms and quorum sensing
Sun Yat-sen University
2011-2025
The First Affiliated Hospital, Sun Yat-sen University
2012-2025
Sichuan University
2025
Ningbo University
2022-2024
National Cheng Kung University
2022-2023
Fujian Medical University
2023
Fujian Provincial Cancer Hospital
2023
Zhejiang University of Technology
2020-2022
Harbin Medical University
2022
Second Affiliated Hospital of Harbin Medical University
2022
Nemo-like kinase (NLK) is an evolutionarily conserved protein involved in Wnt/beta-catenin signaling, which has been reported to be associated with gliomagenesis. In the present study, we aimed identify a concrete mechanism of pathway regulation by microRNAs (miRNAs) glioma. Quantitative reverse-transcription polymerase chain reaction and situ hybridization were conducted detect expression miR-92b. The cell proliferation rate cycle kinetics detected using 3-(4,5)-dimethylthiahiazo...
A key limitation in using heterologous genomic or metagenomic libraries functional genomics and genome engineering is the low expression of genes screening hosts, such as Escherichia coli. To overcome this limitation, here we generate E. coli strains capable recognizing promoters by expressing sigma factors. Among seven factors tested, RpoD from Lactobacillus plantarum (Lpl) appears to be able initiating transcription all sources DNA. Using promoter GFP-trap concept, successfully screen...
Hepatocellular carcinoma (HCC) accounts for almost 80% of all liver cancer cases and is the sixth most common second cause cancer-related death worldwide. The survival rate sorafenib-treated advanced HCC patients still unsatisfactory. Unfortunately, no useful biomarkers have been verified to predict sorafenib efficacy in HCC.We assessed a resistance-related microarray dataset found that anterior gradient 2 (AGR2) highly associated with overall recurrence-free several clinical parameters HCC....
Enhancement of protein synthesis from mRNA translation is one the key steps supporting cardiomyocyte hypertrophy during cardiac remodeling. The methyltransferase-like5 (METTL5), which catalyzes m6A modification 18S rRNA at position A1832, has been shown to regulate efficiency differentiation ES cells and growth cancer cells. It remains unknown whether how METTL5 regulates hypertrophy. In this study, we have generated a mouse model, METTL5-cKO, with cardiac-specific depletion in vivo. Loss...
From initial human papillomavirus (HPV) infection and precursor stages, the development of cervical cancer takes decades. High-sensitivity HPV DNA testing is currently recommended as primary screening method for cancer, whereas better triage methodologies are encouraged to provide accurate risk management HPV-positive women. Given that virus-driven genomic variation accumulates during carcinogenesis, we designed a 39 Mb custom capture panel targeting 17 types 522 mutant genes related cancer....
Background: Atrial fibrillation (AF) is prevalent in dialysis-dependent patients, who face higher risks of thromboembolism and bleeding. Although vitamin K antagonists (VKAs) are commonly used for anticoagulation, the benefits factor Xa (FXa) inhibitors over VKAs this population unclear. This systematic review aims to compare efficacy safety FXa based on randomized controlled trials (RCTs). Methods: We conducted a search PubMed Embase RCTs comparing up November 2024. The primary outcome was...
The MYC genes encode nuclear sequence specific–binding DNA-binding proteins that are pleiotropic regulators of cellular function, and the c-MYC proto-oncogene is deregulated and/or mutated in most human cancers. Experimental studies binding to genome not fully consistent. While many recognition sites can be identified responsive genes, other motif matches—even experimentally confirmed sites—are associated with showing no response. We have developed a computational model integrates multiple...
For insight into transcriptional mechanisms mediating physiological responses to GH, data mining was performed on a profile of GH-regulated genes induced or inhibited at different times in highly responsive 3T3-F442A adipocytes. Gene set enrichment analysis indicated that are enriched pathways including phosphoinositide and insulin signaling suggested suppressor cytokine 2 (SOCS2) 3' kinase regulatory subunit p85alpha (Pik3r1) important targets. Model-based Chinese restaurant clustering...
This study introduces an optical DNA-based logic circuit that mimics a half-subtractor. The system contains Au-surface immobilized molecular-beacon molecule serves as dual-gate and outputs two series of fluorescence signals following Boolean INH XOR patterns after interacting with one or single-stranded DNA molecules input. To the best our knowledge, reported herein is rather concise compared to other molecular gate systems.
Resistance against ceftazidime-avibactam (CZA) in carbapenem-resistant Pseudomonas aeruginosa (CRPA) is emerging. This study was aimed at detecting the prevalence and molecular characteristics of CZA-resistant CRPA clinical isolates Guangdong Province, China. The antimicrobial susceptibility profile these strains determined. A subset 16 analysed by whole-genome sequencing (WGS). Genetic surroundings carbapenem resistance genes pan-genome-wide association analysis were further studied. Of 250...
Ceramide synthases (CSs) produce ceramides from long-chain bases (LCBs). However, how CSs regulate immunity and cell death in Arabidopsis thaliana remains unclear. Here, we decipher the roles of two classes CS, CSI (LAG1 HOMOLOG 2, LOH2) CSII (LOH1/3), these processes. The loh1-2 loh1-1 loh3-1 mutants were resistant to bacterial pathogen Pseudomonas syringae pv maculicola (Psm) DG3 exhibited programmed (PCD), along with increased LCBs ceramides, at later stages. In loh1-2, Psm resistance,...
Acinetobacter baumannii, a strictly aerobic, non-lactose fermented Gram-negative bacteria, is one of the important pathogens nosocomial infection. Major facilitator superfamily (MFS) transporter membrane proteins are class that widely exists in microbial genomes and have been revealed to be related biofilm formation variety microorganisms. However, as MFS proteins, little known about role BIT33_RS14560 A. baumannii. To explore effects on abilities 62 isolates were firstly investigated...