A5063926271- Cervical Cancer and HPV Research
- Hepatitis B Virus Studies
- Cancer-related molecular mechanisms research
- Hepatitis Viruses Studies and Epidemiology
- Epigenetics and DNA Methylation
- Liver Disease Diagnosis and Treatment
- Hepatitis C virus research
- Genital Health and Disease
- Cancer-related Molecular Pathways
- MicroRNA in disease regulation
- Cancer Cells and Metastasis
- RNA modifications and cancer
- Circular RNAs in diseases
- Cytokine Signaling Pathways and Interactions
- T-cell and Retrovirus Studies
- NF-κB Signaling Pathways
- Cancer Genomics and Diagnostics
- Drug-Induced Hepatotoxicity and Protection
- Molecular Biology Techniques and Applications
- Liver Disease and Transplantation
- RNA Interference and Gene Delivery
- Reproductive tract infections research
- Cancer, Hypoxia, and Metabolism
- Curcumin's Biomedical Applications
- Reproductive System and Pregnancy
Cotton University
2025
Amity University
2015-2024
Institute of Molecular Medicine
2015-2024
Amity University
2024
Shree Guru Gobind Singh Tricentenary University
2024
Institute of Public Health Bengaluru
2023
University of Delhi
2009-2018
Ambedkar University Delhi
2009-2018
Bharathidasan University
2015
Institute of Cytology and Preventive Oncology
2004-2014
Head and neck squamous cell carcinomas (HNSCCs) are the most devastating diseases in India southeast Asia. It is a preventable curable disease if detected early. Tobacco alcohol consumption two major risk-factors but infection of high-risk HPVs also associated with development predominantly oral oropharyngeal carcinomas. Interestingly, unlike cervical cancer, HPV-induced HNSCCs show good prognosis better survival contrast, majority tobacco-associated HPV−ve highly aggressive poor clinical...
Abstract Background and Aim: Hepatitis E virus (HEV) infection leading to fulminant hepatic failure (FHF) high mortality is a common feature in Indian women during the second third trimesters of pregnancy. An altered status hormones immunity are observed pregnancy but actual cause still unknown. The present study was carried out analyze CD3, CD4 CD8 T cell counts assay level pregnancy‐related such as estrogen, progesterone β‐HCG order discover role played by these factors. Methods: One...
The transcription factor AP-1 plays a central role in the transcriptional regulation of specific types high-risk human papillomaviruses (HPVs) such as HPV16 and HPV18, which are etiologically associated with development cancer uterine cervix women. In our study, we investigated binding activity expression pattern different members family (c-Jun, JunB, JunD, c-Fos, FosB, Fra-1 Fra-2) grades cervical lesions starting from mild dysplasia to invasive tumors, including normal control tissues,...
Abstract Background- Specific types of high risk Human papillomaviruses (HR-HPVs) particularly, HPV 16 and 18 cause cervical cancer while the two recently developed vaccines against these are prophylactic in nature, therapeutic options for treatment management already existing infection not available as yet. Because transcription factor, Activator Protein-1 (AP-1) plays a central role HPV-mediated carcinogenesis, we explored possibility its targeting by berberine, natural alkaloid derived...
Abstract Background Bryophyllum pinnata ( B. ) is a common medicinal plant used in traditional medicine of India and other countries for curing various infections, bowel diseases, healing wounds ailments. However, its anticancer properties are poorly defined. In view broad spectrum therapeutic potential we designed study to examine anti-cancer anti-Human Papillomavirus (HPV) activities leaf extracts tried isolate active principle. Methods A chloroform extract derived from bulk botanically...
Background Infection of specific high risk Human papillomaviruses (HPVs) is known to cause cervical cancer and two prophylactic vaccines have been developed against major HPV types 16 18 for prevention cancer. Because societal, religious ethical issues associated with the vaccination adolescent girls in India together lack awareness about vaccines, no successful immunization program has employed India. Objective To determine knowledge, attitude college students on HPV, vaccine Method A...
The incidence and severity of hepatitis E virus (HEV) infection in pregnant women is high developing countries. Transplacental transmission HEV the third trimester pregnancy has been found to be associated with fetal mortality. Based on this evidence absence reports replication extrahepatic sites, study was carried out investigate if occurs placenta infected mothers. included 68 acute viral (AVH) 22 liver failure (ALF) patients. Viral RNA extracted from blood placenta. confirmed by a...
Perturbation of keratinocyte differentiation by E6/E7 oncoproteins high-risk human papillomaviruses that drive oncogenic transformation cells in squamocolumnar junction the uterine cervix may confer "stem-cell like" characteristics. However, crosstalk between and stem cell signaling during cervical carcinogenesis is not well understood. We therefore examined role viral maintenance stemness cancer.Isolation enrichment cancer stem-like (CaCxSLCs) was done from primary tumors lines novel...
Integration of human papillomavirus (HPV) DNA into the host cell genome is believed to be essential for malignant progression. However unambiguous detection physical state HPV a difficult and time-consuming procedure. To resolve this issue simple, rapid highly sensitive technique polymerase chain reaction (PCR) has been utilized detecting HPV-16 DNA. Investigations were carried out in 122 cervical specimens comprising whole spectrum lesions starting from dysplasia invasive carcinoma...
Oral cancer is one of the most common cancers in India and south-east Asian region consisting more than 50% all malignant tumors. Along with many known risk factors, infection Human Papillomavirus (HPV) has been associated development oral suggested to modulate host cell transcription. Reciprocally, cellular transcription such as NF-kappaB AP-1 are expression viral other genes involved cancer. In absence data on relation HPV cancer, we studied DNA binding activity pattern family proteins...
Hepatitis E is a major health problem in developing countries including India. The incidence and mortality rate pregnant women with fulminant hepatic failure (FHF) due to hepatitis virus (HEV) has been reported be significantly higher, specifically Asian women. Pregnancy usually associated an altered status of sex steroid hormones immunity. Steroid directly influence the replication through their effects on viral regulatory elements. Moreover, Asia generally suffer from folate deficiency,...
Ninety-six colposcopically directed biopsies from squamous epithelial carcinoma of the uterine cervix and 22 age-matched normal control biopsy specimens were examined by both Southern blot hybridization polymerase chain reaction (PCR) for presence different human papillomavirus (HPV) DNA types. Cancer cervix, which is most common malignant disease in Indian women, showed a high frequency (98%) HPV as compared to those reported other parts world. type 16 was found be dominant (64%) while 18...
ABSTRACT High-risk human papillomaviruses (HPVs), particularly HPV types 16 and 18 (HPV-16 HPV-18, respectively), play a cardinal role in the etiology of cervical cancer. The most prevalent type, HPV-16, shows intratypic sequence variants that are known to differ oncogenic potential geographic distribution. This study was designed analyze variations E6, E7, L1 genes LCR (for long control region) HPV-16 cancer patients identify novel correlate them with severity disease. Cervical biopsies...
Abstract Background Recent observations indicate potential role of transcription factor STAT3 in cervical cancer development but its specifically with respect to HPV infection is not known. Present study has been designed investigate expression and activation precancer relation during carcinogenesis. Established cell lines prospectively-collected tissues were analyzed for the positivity evaluated phosphorylation by immunoblotting immunohistochemistry whereas STAT3-specific DNA binding...
The present study is aimed at developing and evaluating a combined strategy of dual drug delivery, receptor up-regulation, targeting. dendritic architectures were synthesized characterized by IR, 1H-NMR, 13C-NMR spectroscopy. pH-responsive simultaneous release behavior the loaded bioactive from carrier was also explored. cell line studies for MTT cytotoxicity, blockade, up-regulation assays performed on HeLa cells. Treatment cells with low concentration all-trans retinoic acid (ATRA, ∼1 μM)...
Abstract Background and Aim: Antituberculosis drugs, isoniazid rifampicin, in combination, are known to develop drug‐induced hepatotoxicity (DIH). A higher risk of DIH during antituberculosis treatment (ATT) has been reported the Indian subcontinent compared its Western counterparts. The role genetic factors a incidence ATT population is still unclear. present study was aimed at investigating N‐acetyltransferase2 (NAT2) cytochrome P4502E1 (CYP2E1) gene polymorphisms hepatotoxicity. Methods:...