A5100610483- MicroRNA in disease regulation
- Cancer-related molecular mechanisms research
- Circular RNAs in diseases
- RNA modifications and cancer
- Cancer, Hypoxia, and Metabolism
- Pulmonary Hypertension Research and Treatments
- Cancer, Lipids, and Metabolism
- Cancer Genomics and Diagnostics
- Breast Cancer Treatment Studies
- Single-cell and spatial transcriptomics
- NF-κB Signaling Pathways
- RNA Research and Splicing
- Neuroscience and Neuropharmacology Research
- Cytokine Signaling Pathways and Interactions
- Axon Guidance and Neuronal Signaling
- Fibroblast Growth Factor Research
- Autophagy in Disease and Therapy
- Microbial Inactivation Methods
- Plant-Microbe Interactions and Immunity
- Hormonal Regulation and Hypertension
- Essential Oils and Antimicrobial Activity
- Membrane-based Ion Separation Techniques
- Transgenic Plants and Applications
- FOXO transcription factor regulation
- Cerebrovascular and genetic disorders
University of Pennsylvania
2024
Central South University
2016-2024
Tongji Hospital
2009-2024
Huazhong University of Science and Technology
2009-2024
Chinese Academy of Medical Sciences & Peking Union Medical College
2021-2023
Women's Hospital, School of Medicine, Zhejiang University
2023
Fudan University
2022
State Key Laboratory of Medical Neurobiology
2022
Quzhou City People's Hospital
2021
Chongqing University of Education
2020
MicroRNAs (miRNAs) are small non-coding RNAs that key post-transcriptional regulators of gene expression. MicroRNA-214 (miR-214) and microRNA-218 (miR-218) have shown the function tumor suppressors in various types human cancers. However, biological functions miR-214 miR-218 breast cancer not been elucidated completely. The present study evaluated expression cancer. Our results revealed were significantly decreased tissues compared with adjacent tissues. aberrant negatively associated Ki-67,...
Long non-coding RNA FOXD2 Adjacent Opposite Strand 1 (FOXD2-AS1) has been widely reported to be implicated in the progression and recurrence of several cancers. The clinical significance functional role FOXD2-AS1 thyroid carcinoma remain unknown. expression was evaluated by analyzing cancer sequencing dataset from Cancer Genome Atlas (TCGA). In vitro vivo assays were performed assess biological roles cells. Western blot, luciferase, immunoprecipitation (IP) (RIP) used identify underlying...
Abstract Background Studies have shown that sperm-borne microRNAs (miRNAs) are involved in mammalian preimplantation embryonic development. In humans, spermatozoan miR-34c levels correlated with vitro fertilization outcomes, such as embryo quality and the clinical pregnancy live birth rates. rabbits cows, improves developmental competence of embryos generated by somatic cell nuclear transfer. However, mechanisms underlying regulation development remain unknown. Methods Female C57BL/6 mice...
The present work aimed to probe into the effect of long non-coding RNA (lncRNA) LINC00152 on gastric cancer (GC) cells proliferation by regulating miR-193a-3p and its target gene MCL1. Transfected si-LINC00152 was used down-regulate LINC00152, measured cell counting kit-8 (CCK-8) assay. Cell apoptosis cycle were analyzed flow cytometry (FCM). Besides, we also detected potential functional effects differential expression in vivo using nude mouse xenograft model. We overexpressed downexpressed...
// Huiling Li 1, 2 , Xiaoling Xiaolu Ge Liqing Jia Zhezhe Zhang Renpeng Fang 4 Jing Yang Jianpin Liu 3 Shuping Peng Ming Zhou Juanjuan Xiang Zhaoyang Zeng Wen Wei Xiong Gaoming Xiao 1 Gui-yuan Zheng 2, Hunan Cancer Hospital and The Affiliated of Xiangya School Medicine, Central South University, Changsha, China Key Laboratory Carcinogenesis Chinese Ministry Health Invasion Education, Research Institute, High Resolution Mass Spectrometry Advanced Center, Correspondence to: Li, email:...
THIS ARTICLE WAS WITHDRAWN BY THE PUBLISHER IN NOVEMBER 2020
Ischemic stroke, which accounts for 87% of all strokes, constitutes the leading cause morbidity and mortality in China. Although genetics epigenetics stroke have been extensively investigated, few studies examined their relationships at different stages stroke. This study assessed characteristics transcriptome changes ischemic using a mouse model transient middle cerebral artery occlusion (tMCAO) bioinformatics analyses. Cerebral cortex tissues from tMCAO mice days 1, 3, 7, 14, 28 were...
Abstract Objectives: The aim of the present study was to determine effects miRNA-103 on chondrocyte apoptosis and molecular mechanisms in osteoarthritis (OA) progression. Methods: cell proliferation, apoptosis, recovery ability were measured by counting kit-8 (CCK-8), flow cytometry, wound healing assays. interaction Sphingosine kinase-1 (SPHK1) determined using luciferase reporter assay. expression mRNA proteins qRT-PCR Western blot. OA rat model established surgery stimulation. Results:...
Early Triple negative breast cancer (eTNBC) is the subtype with worst outcome. Circulating tumor DNA (ctDNA) shown to predict prognosis of cancer, but its utility in eTNBC remains unclear. 130 stage II-III female patients receiving neoadjuvant chemotherapy (NAC) have been enrolled prospectively and subjected ctDNA analysis. at post-NAC (pre-surgery) post-surgery, not baseline, associated worse prognosis. A threshold 1.1% maximum variant allele frequency baseline stratifies different relapse...
Fibroblast activation is one of the most important mechanisms for Angiotensin II (Ang II) in promoting renal fibrosis. Transcription factor Ets-1 recognized to play a key role kidney diseases. However, and Ang-II induced fibroblast fibrosis are not fully understood.Mice were treated with Ang via osmotic mini-pumps or expression plasmid (pAng II). Cultured normal rat interstitial (NRK-49F) cells incubated II. Role assessed by Western blot, Immunohistochemical staining'MTT, Boyden chamber...
MicroRNAs (miRNAs) are small ribonucleotides regulating gene expression. present in the blood a remarkably stable form and have emerged as potential diagnostic markers patients with cardiovascular disease. Our study aimed to assess circulating miR-133a levels MHD relation of cardiac hypertrophy.
Background Regulator of G-protein Signaling 4 (RGS4) plays an important role in regulating smooth muscle contraction, cardiac development, neural plasticity and psychiatric disorder. However, the underlying regulatory mechanisms remain elusive. Our recent studies have shown that upregulation Rgs4 by interleukin (IL)-1β is mediated activation NFκB signaling modulated extracellular signal-regulated kinases, p38 mitogen-activated protein kinase, phosphoinositide-3 kinase. Here we investigate...
Deficiency of glutamate transporter GLAST in Müller cells may be culpable for excessive extracellular glutamate, which involves retinal ganglion cell (RGC) damage glaucoma. We elucidated how was regulated rat chronic ocular hypertension (COH) model. Western blot and whole-cell patch-clamp recordings showed that proteins GLAST-mediated current densities were downregulated at the early stages COH. In normal rats, intravitreal injection ephrinA3 activator EphA4-Fc mimicked changes COH retinas....
Atorvastatin (Lipitor™) is a lipid‑lowering agent that widely used in the treatment of cardiovascular diseases. Previous research has largely focused on its cholesterol‑lowering effects; however, limited number studies have investigated actions atorvastatin vascular endothelial cells. In present study, effects various doses were human umbilical vein cells (HUVECs). HUVECs treated with concentrations serum‑free or serum‑containing medium, and alterations HUVEC morphology observed. Cell...
Abstract Background Neurological complications are a significant concern of Coronavirus Disease 2019 (COVID-19). However, the pathogenic mechanism neurological symptoms associated with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection is poorly understood. Methods We used Drosophila as model to systematically analyze SARS-CoV-2 genes encoding structural and accessory proteins identified membrane protein (M) that disrupted mitochondrial functions in vivo. The M was...
Breast cancer is a malignant tumor that occurs in the epithelial tissue of breast gland and has become most common malignancy women. The regulation expression related genes by microRNA (miRNA) plays an important role cancer. We constructed comprehensive cancer-miRNA-gene interaction map.Three miRNA microarray datasets (GSE26659, GSE45666, GSE58210) were obtained from GEO database. Then, R software "LIMMA" package was used to identify differential analysis. Potential transcription factors...
To explore the expression of microribonucleic acid-340 (miR-340) and cyclin D1 (CCND1) in lung cancer (LC) tissues its relationship with clinicopathological characteristics prognosis LC.Cancer paracancerous normal 65 patients LC admitted to our hospital from January 2014 March 2015 were included as group, respectively.The relative levels miR-340 mRNA protein group lower than those while CCND1 higher (P < 0.05). Pearson correlation analysis results showed that both was negatively correlated...