A5101826275- Genomics and Phylogenetic Studies
- RNA modifications and cancer
- Plant Gene Expression Analysis
- Nitrogen and Sulfur Effects on Brassica
- Plant Pathogens and Fungal Diseases
- Bone Metabolism and Diseases
- RNA Research and Splicing
- Plant and Fungal Species Descriptions
- Cancer-related molecular mechanisms research
- Plant Diversity and Evolution
- Genomics and Chromatin Dynamics
- MicroRNA in disease regulation
- Lipid metabolism and biosynthesis
- Plant Disease Resistance and Genetics
- Plant Parasitism and Resistance
- Genetic Associations and Epidemiology
- Photosynthetic Processes and Mechanisms
- Genetic diversity and population structure
- Chromosomal and Genetic Variations
- Circular RNAs in diseases
- RNA and protein synthesis mechanisms
- Genetic Neurodegenerative Diseases
- Plant Molecular Biology Research
- Plant-derived Lignans Synthesis and Bioactivity
- Plant biochemistry and biosynthesis
Hunan Academy of Agricultural Sciences
2022-2025
Zhejiang Academy of Forestry
2008-2025
Hybrid Rapeseed Research Center of Shaanxi Province
2021-2025
Longgang Central Hospital
2023-2024
People's Hospital of Xinjiang Uygur Autonomous Region
2024
Hunan Agricultural University
2022-2024
Gansu Agricultural University
2023-2024
Xinjiang Medical University
2024
Tsinghua University
2021-2023
Beijing Sport University
2022
The PAF1 complex (PAF1C) functions in multiple transcriptional processes involving RNA polymerase II (RNA Pol II). Enhancer RNAs (eRNAs) and promoter upstream transcripts (PROMPTs) are pervasive transcribed by degraded rapidly the nuclear exosome after 3' endonucleolytic cleavage Integrator (Integrator). Here we show that PAF1C has a role termination of eRNAs PROMPTs cleaved 1-3 kb downstream transcription start site. Mechanistically, facilitates recruitment to sites transcript cleavage,...
SUMMARY Understanding the genetic basis of population divergence and adaptation is an important goal in genetics evolutionary biology. However, relative roles demographic history, gene flow, and/or selective regime driving genomic divergence, climatic adaptation, speciation non‐model tree species are not yet fully understood. To address this issue, we generated whole‐genome resequencing data Liquidambar formosana L. acalycina , which broadly sympatric but altitudinally segregated Tertiary...
Metabolites are key indicators of health and therapeutic targets, but their genetic underpinnings during pregnancy-a critical period for human reproduction-are largely unexplored. Using data from non-invasive prenatal testing, we performed a genome-wide association study on 84 metabolites, including 37 amino acids, 24 elements, 13 hormones, 10 vitamins, involving 34,394 pregnant Chinese women, with sample sizes ranging 6,394 to 13,392 specific metabolites. We identified 53 metabolite-gene...
Cerasus serrulata is a flowering cherry germplasm resource for ornamental purposes. In this work, we present de novo chromosome-scale genome assembly of C. by the use Nanopore and Hi-C sequencing technologies. The assembled 265.40 Mb across 304 contigs 67 scaffolds, with contig N50 1.56 scaffold 31.12 Mb. It contains 29,094 coding genes, 27,611 (94.90%) which are annotated in at least one functional database. Synteny analysis indicated that avium have 333 syntenic blocks composed 14,072...
Allopolyploid oilseed rape (Brassica napus) is an important oil crop and vegetable. However, the latest version of its reference genome, with collapsed duplications, gaps, other issues, prevents comprehensive genomic analysis. Herein, we report a gap-free assembly rapeseed cv. Xiang5A genome using combination ONT (Oxford Nanopore Technologies) ultra-long reads, PacBio high-fidelity Hi-C datasets. It includes assemblies all 19 chromosomes telomere-to-telomere eight chromosomes. Compared...
Phoebe (Lauraceae) comprises of evergreen trees or shrubs with approximately 100 species, distributed in tropical and subtropical Asia Neotropical America. A total 34 species three varieties occur China. Despite economic ecological value, only limited genomic resources are available for this genus.We sequenced the two complete chloroplast (cp) genomes chekiangensis P. bournei using Illumina sequencing technology via a combined strategy de novo reference-guided assembly. We also performed...
Prunus campanulata, a species of ornamental cherry, holds significant genetic and horticultural value. Despite the availability various cherry genomes, fully resolved telomere-to-telomere (T2T) assembly for this has been lacking. Recent advancements in long-read sequencing technologies have made it possible to generate gap-free genome assemblies, providing comprehensive insights into genomic structures that were previously inaccessible. We present first T2T P. campanulata "Lianmeiren"...
Low temperature is a major environmental factor, which limits rapeseed (Brassica napus L.) growth, development, and productivity. So far, the physiological molecular mechanisms of responses to cold stress are not fully understood. Here, we explored transcriptome metabolome profiles two genotypes with contrasting responses, i.e., XY15 (cold-sensitive) GX74 (cold-tolerant). The global profiling detected 545 metabolites in siliques both before (CK) after cold-stress treatment (LW). contents...
ω-Conotoxins inhibit N-type voltage-gated calcium (CaV2.2) channels and exhibit efficacy in attenuating neuropathic pain but have a low therapeutic index. Here, we synthesized characterized novel ω-conotoxin, Bu8 from Conus bullatus, which consists of 25 amino acid residues three disulfide bridges. selectively potently inhibits depolarization-activated Ba2+ currents mediated by rat CaV2.2 expressed HEK293T cells (IC50 = 89 nmol/L). is two-fold more potent than ω-conotoxin MVIIA, currently...
Cherries (Prunus Subgenus Cerasus) have economic value and ecological significance, yet their phylogeny, geographic origin, timing, dispersal patterns remain challenging to understand. To fill this gap, we conducted a comprehensive analysis of the complete chloroplast genomes 54 subg. Cerasus individuals, along with 36 additional from NCBI database, resulting in total 90 for comparative analysis. The exhibited varying sizes consisted 129 genes, including protein-coding, transfer RNA,...
Genome-wide association studies (GWAS) of type 2 diabetes (T2D) have discovered a number loci that contribute to susceptibility the disease. Future challenges include elucidation functional mechanisms through which these GWAS-identified modulate T2D disease risk. The aim present study was comprehensively characterize associated single nucleotide polymorphisms (SNPs) and genes computational approaches. Computational biology approaches used in included comparative genomic analyses annotation...
Platelet activation participates in the development of both coronary artery disease (CAD) and circulating microparticles (MPs). As a commonly used medicine for heart disease, whether aspirin affects function MPs remains unclear.This study was designed to test from healthy subjects, stable angina (SA) patients before after administration were obtained. origins tested by flow cytometry. Rat thoracic aortas incubated with (with or without aspirin) determine effects on expression ERK1/2, JNKs,...
Cold stress affects the seed germination and early growth of winter rapeseed, leading to yield losses. We employed transmission electron microscopy, physiological analyses, metabolome profiling, transcriptome sequencing understand effect cold (0 °C, LW) on cotyledons cold-tolerant (GX74) -sensitive (XY15) rapeseeds. The mesophyll cells in cold-treated XY15 were severely damaged compared slightly GX74. fructose, glucose, malondialdehyde, proline contents increased after both genotypes;...
Introduction Tetrastigma hemsleyanum is a folk and rare medicinal plant, specifically, it distributed in the south, China. To investigate cumulative properties of its components, we examined effect UV light on flavonoid content related enzyme activity changes T. . Methods The leaves tubers were treated with UV-A, UV-B UV-C for 1 h, 1L/23D 3 h 3L/21D (D represents darkness treatment). High-performance liquid chromatography (HPLC) analysis showed that many flavonoids decreased significantly...
As a common factor of both type 2 diabetes mellitus (T2DM) and acute coronary syndrome (ACS), circulating microparticles (MPs) may provide link between these two diseases. The present study compared the content function MPs from patients with ACS or without T2DM. healthy subjects (n=20), (n=24), T2DM (n=20) combined (n=24) were obtained. After incubating rat thoracic tissue MPs, effect on endothelial‑dependent vasodilatation, expression caveolin‑1 endothelial nitric oxide synthase...
Abstract Using retinoic acid to inducer, we successfully established a rat model of secondary osteoporosis and verified the preventive effect Lactobacillus fermentum ZS40 (ZS40) on osteoporosis. Serum biochemical indicators showed that can effectively slow down bone resorption caused by acid, increase blood content calcium, phosphorus, alkaline phosphatase, gla protein, insulin‐like growth factor 1, decrease tartrate‐resistant phosphatase (TRAP) 5b. qRT‐PCR results could upregulate mRNA...