A5102853573- Drug Transport and Resistance Mechanisms
- Lung Cancer Research Studies
- RNA modifications and cancer
- Cancer therapeutics and mechanisms
- HIV/AIDS drug development and treatment
- X-ray Diffraction in Crystallography
- Crystallization and Solubility Studies
- Thermal and Kinetic Analysis
- Immunotherapy and Immune Responses
- Energetic Materials and Combustion
- Diabetes Treatment and Management
- Chemical Synthesis and Analysis
- Receptor Mechanisms and Signaling
- Peptidase Inhibition and Analysis
- Antimicrobial Peptides and Activities
- Sperm and Testicular Function
- Chemical Thermodynamics and Molecular Structure
- Protein Degradation and Inhibitors
- Sulfur Compounds in Biology
- RNA Interference and Gene Delivery
- Reproductive Biology and Fertility
- Luminescence and Fluorescent Materials
- Pancreatic function and diabetes
- Molecular Sensors and Ion Detection
- Adenosine and Purinergic Signaling
Zhejiang University
2025
Shanghai Pulmonary Hospital
2024-2025
Tongji University
2024-2025
University of Science and Technology Liaoning
2025
Shaoxing People's Hospital
2025
Shanghai Jiao Tong University
2018-2024
Jiangnan University
2024
Yancheng Teachers University
2019-2024
Shanghai Cancer Institute
2019-2024
Renji Hospital
2018-2024
Abstract Despite progress in treatment of small cell lung cancer (SCLC), its multidrug chemoresistance and poor prognosis still remain. Recently, we globally assessed long non-coding RNAs (lncRNAs) for contributions to SCLC using microarray data, vitro vivo assays. Here reported that HOTTIP, encoding a lncRNA is frequently amplified SCLC, was associated with chemosensitivity, proliferation, patients. Moreover, mechanistic investigations showed HOTTIP functioned as an oncogene progression by...
Purpose: Epithelial and endothelial tyrosine kinase (Etk), also known as bone marrow X (Bmx), was found to be critical in modulating the chemoresistance of small-cell lung cancer (SCLC) our preliminary study. However, molecular mechanisms Etk SCLC remain poorly understood.Experimental Design: We determined correlation with autophagy SCLC. And direct inhibition performed validate its effect on chemoresistance. Coimmunoprecipitation (co-IP) GST-pull down experiments were conducted verify...
The feedback activation of the Janus kinase (JAK)–STAT pathway leads to fact that solid cancers are not sensitive histone deacetylase (HDAC) inhibitors. Herein, a series novel 2-amino-4-phenylaminopyrimidine JAK/HDAC dual-target inhibitors based on moiety fedratinib were designed and synthesized. Among them, 21 30 potently inhibited HDAC3/6 JAK1/2 at nanomolar levels exhibited splendid selectivity for JAK2 against panel 76 kinases. presented remarkable antiproliferative activity in both...
Metabolic reprogramming is a hallmark of human cancer, and cancer-specific metabolism provides opportunities for cancer diagnosis, prognosis, treatment. However, the underlying mechanisms by which metabolic pathways affect initiation progression colorectal (CRC) remain largely unknown. Here, we demonstrate that cysteine highly enriched in tumors compared to adjacent non-tumor tissues, thereby promoting tumorigenesis CRC. Synchronously importing both cystine cells necessary maintain...
Several lines of evidence highlight the important application human spermatogonial stem cells (SSCs) in translational medicine. The fate decisions SSCs are mainly mediated by genetic and epigenetic factors. We have recently demonstrated that PAK1 regulates proliferation, DNA synthesis, early apoptosis through PDK1/KDR/ZNF367 ERK1/2 AKT pathway. However, underlying mechanism remains unknown. In this study, we found level miRNA-31-5p was elevated knockdown. CCK-8, PCNA,...
P-glycoprotein (P-gp)-mediated multidrug resistance (MDR) is a principal obstacle for successful cancer chemotherapy. A novel P-gp inhibitor with quinazoline scaffold, 12k, was considered to be the most promising in-depth study. 12k possessed high potency (EC50 = 57.9 ± 3.5 nM), low cytotoxicity, and long duration of activity in reversing doxorubicin (DOX) K562/A02 cells. also boosted other MDR-related cytotoxic agents different structures, increased accumulation DOX, blocked P-gp-mediated...
SIS3 is a specific inhibitor of Smad3 that inhibits the TGFβ1-induced phosphorylation Smad3. In this article, variety derivatives were designed and synthesized to discover potential inhibitors against P-glycoprotein-mediated multidrug resistance aided by late-stage functionalization 2-(4-(pyridin-2-yl)phenoxy)pyridine analogue. A novel class potent P-gp reversal agents investigated, lead compound 37 was identified as agent with strong bioactivity outstanding affinity for P-gp.
Overexpression of the ATP-binding cassette (ABC) transport proteins, like ABCB1, commonly referred to as P-glycoprotein (P-gp), initiates active efflux a broad spectrum unrelated chemotherapeutic drugs in structure and function, leading chemotherapy failure. A series 2-((pyridin-4-ylmethyl)amino)nicotinamide derivatives potent reversal agents against P-glycoprotein-mediated multidrug resistance (MDR) were designed synthesized. The majority target compounds displayed great potency, especially...
Human spermatogonial stem cells (SSCs) could have significant applications in reproductive medicine and regenerative because of their great plasticity. The fate determinations human SSCs are mediated by epigenetic factors. However, nothing is known about the regulation non-coding RNA on SSCs. Here we explored for first time expression, function, target miR-663a MiR-663a was upregulated spermatogonia compared with pachytene spermatocytes, as indicated microRNA microarray real-time PCR. CCK-8...
Overexpression of ATP binding cassette (ABC) transporters, including P-glycoprotein (P-gp) and breast cancer resistance protein (BCRP), is an important factor leading to multidrug (MDR) in treatments. Three subclasses dual inhibitors P-gp BCRP were designed based on the active moieties inhibitors, tyrosine kinase which compound 21 possessed low cytotoxicity, high reversal potency, good lipid distribution coefficient. also increased accumulation Adriamycin (ADM) Mitoxantrone (MX), blocked...
Abstract Vaccines based on tumour‐specific antigens are a promising approach for immunotherapy. However, the clinical efficacy of is still challenging. Twelve conjugates with self‐assembly properties were designed and synthesized using MAGE‐A1 peptide TLR2 agonist, combined different covalent bonds. All developed formed spherical nanoparticles diameter approximately 150 nm, enhanced vaccines better targeting lymph nodes. could well bind to serum albumin improve plasma stability individual...
Objective Small cell lung cancer (SCLC) is a highly malignant subtype of cancer. Cancer stem (CSC)-like cells have been implicated in chemoresistance and recurrence. Although previous studies demonstrated the significance WASP-interacting protein (WIPF1) tumors, its underlying molecular mechanism SCLC not well known. Here, we demonstrate that WIPF1 can regulate tumorigenesis SCLC. Methods Sphere-formation culture effectively enriches CSC-like cells, such as tumor cell-like cells. RNA-seq was...