A5101742235- Nanoplatforms for cancer theranostics
- Luminescence and Fluorescent Materials
- Hippo pathway signaling and YAP/TAZ
- Neurogenesis and neuroplasticity mechanisms
- Topology Optimization in Engineering
- Immune cells in cancer
- Manufacturing Process and Optimization
- Autophagy in Disease and Therapy
- RNA modifications and cancer
- Single-cell and spatial transcriptomics
- Luminescence Properties of Advanced Materials
- Ferroptosis and cancer prognosis
- Plant Molecular Biology Research
- Metabolism, Diabetes, and Cancer
- Cancer, Lipids, and Metabolism
- Photodynamic Therapy Research Studies
- Sphingolipid Metabolism and Signaling
- Nanoparticle-Based Drug Delivery
- Advanced Battery Materials and Technologies
- Advancements in Battery Materials
- Prostate Cancer Treatment and Research
- Bioinformatics and Genomic Networks
- Aquaculture Nutrition and Growth
- Hepatocellular Carcinoma Treatment and Prognosis
- Axon Guidance and Neuronal Signaling
Harbin Normal University
2024
Second Military Medical University
2021-2024
Zhejiang University
2008-2024
Tianjin Medical University
2016-2024
Second Hospital of Tianjin Medical University
2016-2024
Southern Medical University
2024
Nanfang Hospital
2024
Eastern Hepatobiliary Surgery Hospital
2021-2024
Shaoxing University
2024
Nanjing Medical University
2024
Tissue penetration depth is a major challenge in practical photodynamic therapy (PDT). A biocompatible and highly effective near infrared (NIR)-light-absorbing carbazole-substituted BODIPY (Car-BDP) molecule reported as class of imaging-guidable deep-tissue activatable photosensitizers for PDT. Car-BDP possesses an intense, broad NIR absorption band (600-800 nm) with remarkably high singlet oxygen quantum yield (ΦΔ = 67%). After being encapsulated biodegradable PLA-PEG-FA polymers, can form...
Tumor infiltrated type II (M2) macrophages promote tumorigenesis by suppressing immune clearance, promoting proliferation, and stimulating angiogenesis. Interestingly, were also found to enrich in small foci of altered hepatocytes containing liver tumor-initiating cells (TICs). However, whether how TICs specifically recruit the function these tumor initiation remain unknown due technical difficulties. In this study, generating genetically defined TICs, we demonstrate that actively M2 from as...
Spatial transcriptome technique was applied to decipher the spatial architecture and TME characteristics of liver cancers.
Photodynamic therapy (PDT) is an important cancer treatment modality due to its minimally invasive nature. However, the efficiency of existing PDT drug molecules in deep‐tissue‐penetrable near‐infrared (NIR) region has been major hurdle that hindered further development and clinical usage PDT. Thus, herein a strategy presented utilize resonance energy transfer (RET) mechanism construct novel dyad photosensitizer which able dramatically boost NIR photon utility enhance singlet oxygen...
Abstract Photolysis has enabled the occurrence of numerous discoveries in chemistry, drug discovery and biology. However, there is a dearth efficient long wavelength light mediated photolysis. Here, we report general single photon method for wide array photolytic molecules via triplet-triplet annihilation This versatile “LEGO”-like. The partners (the photosensitizers molecules) can be energetically matched to adapt an extensive range electromagnetic spectrum wavelengths diversified chemical...
Abstract Mitochondria generate ATP and play regulatory roles in various cellular activities. Cancer cells often exhibit fragmented mitochondria. However, the underlying mechanism remains elusive. Here we report that a mitochondrial protein FUN14 domain containing 2 ( FUNDC2 ) is transcriptionally upregulated primary mouse liver tumors, approximately 40% of human hepatocellular carcinoma (HCC). Importantly, elevated expression inversely correlates with patient survival, its knockdown inhibits...
Mechanistic study and precision treatment of primary liver cancer (PLC) are hindered by marked heterogeneity, which is challenging to recapitulate in any given mouse model. Here, we report the generation 25 models PLC situ genome editing hepatocytes recapitulating single or combinations human driver genes. These tumors represent major histopathological types PLCs could be divided into three human-matched molecular subtypes based on transcriptomic proteomic profiles. Phenotypical...
Biocompatibility, targeting, and clearance are key challenges in the design of new MRI contrast agents. Herein, we report on a tumor-targeting, gadolinium biomineralized human transferrin (Tf) protein-based nanoparticle (Gd@Tf NP) for use. As compared to conventionally used chelates, resultant Gd@Tf NPs possess outstanding chemical stability exhibited superior longitudinal relaxation. More importantly, our MR images show that indeed retained natural tumor targeting ability subsequent...
Transport of mRNA from nucleus to cytoplasm is critical for eukaryotic gene expression; however, the mechanism export unknown. Selection and screening procedures have therefore been used obtain a family temperature-sensitive conditional mutants Saccharomyces cerevisiae that accumulate poly(A)+ RNA in when incubated at 37 degrees C, as judged by situ hybridization. In one such transport mutant, mtr1-1, synthesis continues, inhibited, intranuclear remarkably stable, protein gradually stops....
Abstract Vps35 (vacuolar protein sorting 35) is a key component of retromer that regulates transmembrane trafficking. Dysfunctional risk factor for neurodegenerative diseases, including Parkinson’s and Alzheimer’s diseases. highly expressed in developing pyramidal neurons, its physiological role neurons remains to be explored. Here, we provide evidence embryonic necessary axonal dendritic terminal differentiation. Loss results not only differentiation deficits, but also pathology, such as...
Although additive manufacturing (AM) continues to gain widespread adoption, the overhang problem remains a critical issue affecting printing quality. The design of self-supporting structures via topology optimisation approaches has been extensively studied. However, current research predominantly focuses on 3-axis AM machines, overlooking more recently developed multi-axis machines. Moreover, performance sacrifice due constraints in can be significant, especially with small volume fractions....
The high mutation rate of CTNNB1 (37 %) and Wnt-β-catenin signal-associated genes (54 has been notified in hepatocellular carcinoma (HCC). activation signal pathway was reported to be associated with an immune "desert" phenotype, but the underlying mechanism remains unclear. Here we mainly employed orthotopic HCC models explore on it. Mass cytometry depicted contexture syngeneic grafts, unveiling that exogenous expression β-catenin significantly increased percentage myeloid-derived...
Artemia has attracted much attention for its ability to produce encysted embryos wrapped in a protective shell when subject extremely harsh environmental conditions. However, what the cyst is synthesized from and how formative process performed remains, as yet, largely unknown. Over 20 oviparous specifically expressed genes were identified through screening subtracted cDNA library enriched between ovoviviparous ovisacs. Among them, gland-specifically gene (SGEG) been found be involved...
Abstract A strategy to expand anti‐Stokes shifting from the far‐red deep‐blue region in metal‐free triplet–triplet annihilation upconversion (TTA‐UC) is presented. The method demonstrated by vivo titration of photorelease an anticancer prodrug. This new TTA system has robust brightness and longest shift any reported system. core–shell‐structured prodrug delivery capsules that benefit these properties were developed; they can operate with low‐power density light‐emitting diode light. These...
The purpose of this study was to interrogate the potential role N6-methyladenosine (m6A) regulators in process trabecular meshwork (TM) tissue damage patients with primary open-angle glaucoma (POAG). Firstly, expression profile m6A TM tissues POAG comprehensively analyzed by bioinformatics analysis; Plasmid transfection and siRNA gene interference were used enhance or weaken levels YTHDC2 human cells (HTMCs); Cell migration ability detected transwell chamber assay; Immunofluorescence...
Background Many species of the brine shrimp Artemia are found in various severe environments many parts world where extreme salinity, high UV radiation levels, pH, anoxia, large temperature fluctuations, and intermittent dry conditions often recorded. To withstand adverse environments, undergoes an oviparous developmental pathway to release cysts whereas, under favorable conditions, swimming nauplius larvae formed directly via ovoviviparous pathway. In former case these have extraordinary...
Castration resistant prostate cancer (CRPC) is a stage of relapse that arises after various forms androgen ablation therapy (ADT) and causes significant morbidity mortality. However, the mechanism underlying progression to CRPC remains poorly understood. Here, we report YAP1, which negatively regulated by AR, influences (PCa) cell self-renewal development. Specifically, found AR directly regulates methylation YAP1 gene promoter via formation complex with Polycomb group protein EZH2 DNMT3a....
Hydrocephalus is a pathologic condition associated with various brain diseases, including Alzheimer's disease (AD). Dysfunctional ependymal cells (EpCs) are believed to contribute the development of hydrocephalus. It thus interest investigate EpCs' and function. Here, we report that vacuolar protein sorting-associated 35 (VPS35) critical for EpC differentiation, ciliogenesis, survival, preventing neonatal VPS35 abundantly expressed in EpCs. Mice conditional knock-out (cKO) Vps35 embryonic...