A5101939279- Metamaterials and Metasurfaces Applications
- Coral and Marine Ecosystems Studies
- Acoustic Wave Phenomena Research
- Mitochondrial Function and Pathology
- Nonlinear Photonic Systems
- Topological Materials and Phenomena
- Advanced Materials and Mechanics
- ATP Synthase and ATPases Research
- Crystal Structures and Properties
- Plant Ecology and Soil Science
- Nonlinear Optical Materials Research
- Mechanical and Optical Resonators
- Forest ecology and management
- Model Reduction and Neural Networks
- Ubiquitin and proteasome pathways
- Ichthyology and Marine Biology
- X-ray Diffraction in Crystallography
- Fluid Dynamics and Vibration Analysis
- RNA modifications and cancer
- Crystallization and Solubility Studies
- Forest, Soil, and Plant Ecology in China
- Force Microscopy Techniques and Applications
- Solid-state spectroscopy and crystallography
- Modular Robots and Swarm Intelligence
- DNA Repair Mechanisms
Tianjin University of Technology
2023-2025
American Institute of Aeronautics and Astronautics
2019-2024
University of Washington
2019-2024
University of Michigan
2024
Tibet Autonomous Region People's Hospital
2023
Zhejiang University
2020-2022
Huazhong University of Science and Technology
2018-2021
Wuhan National Laboratory for Optoelectronics
2018-2021
Chinese Academy of Forestry
2021
State Forestry and Grassland Administration
2021
Topological elastic metamaterials offer insight into classic motion law and open up opportunities in quantum information processing. Theoretical modeling numerical simulation of topological states have been reported, whereas the experimental observation remains relatively unexplored. Here we present an tunable soft metamaterials. The on-demand reversible switch phase has achieved by changing filling ratio, tension, and/or compression By combining two with distinct invariants, further...
The human kinome comprises 538 kinases playing essential functions by catalyzing protein phosphorylation. Annotation of subcellular distribution the greatly facilitates investigation normal and disease mechanisms. Here, we present Kinome Atlas (KA), an image-based map annotated to 10 cellular compartments. 456 epitope-tagged kinases, representing 85% kinome, were expressed in HeLa cells imaged immunofluorescent microscopy under a similar condition. KA revealed kinase family-enriched...
Abstract Mitochondria generate ATP and play regulatory roles in various cellular activities. Cancer cells often exhibit fragmented mitochondria. However, the underlying mechanism remains elusive. Here we report that a mitochondrial protein FUN14 domain containing 2 ( FUNDC2 ) is transcriptionally upregulated primary mouse liver tumors, approximately 40% of human hepatocellular carcinoma (HCC). Importantly, elevated expression inversely correlates with patient survival, its knockdown inhibits...
Mechanistic study and precision treatment of primary liver cancer (PLC) are hindered by marked heterogeneity, which is challenging to recapitulate in any given mouse model. Here, we report the generation 25 models PLC situ genome editing hepatocytes recapitulating single or combinations human driver genes. These tumors represent major histopathological types PLCs could be divided into three human-matched molecular subtypes based on transcriptomic proteomic profiles. Phenotypical...
Abstract Acoustic metasurfaces that can manipulate and control sound waves at 2D subwavelength scales open new avenues to unusual applications, such as asymmetric transmission, super‐resolution imaging, particle manipulation. However, the long‐standing goals of pushing frontier metamaterials research into real practice are still severely constrained by cumbersome configuration, large acoustic loss, rigid structure existing metamaterials. An ultrathin metasurface (10–300 µm in thickness, up...
Strong second-harmonic generation (SHG) and a short ultraviolet (UV) cutoff edge are two crucial yet often conflicting parameters that must be finely tuned in the exploration of nonlinear optical (NLO) materials.
In this paper, we present a method for generating synthetic gauge field in the vertical direction by linearly modulating mass term Dirac equation model. This allows quantization of Landau levels through generated pseudomagnetic field, with chiral zeroth level being topologically protected. An elastic snake state is realized using coupling between and first levels. For demonstration, our theoretical predictions are numerically an medium truss structures arranged honeycomb lattice. Our...
Valley, as a new degree of freedom, raises the valleytronics in fundamental and applied science. The elastic analogs valley states have been proposed by mimicking symmetrical structure either two-dimensional materials or photonic crystals. However, asymmetrical construction remains unfulfilled. Here, we present anisotropy introducing design into metamaterials. metamaterials are composed bio-inspired hard spirals soft materials. anisotropic topological nature is verified distribution Berry...
Two new rare earth borate NLO crystals, K6NaSrY2B15O30 and Rb7BaLu2B15O30, were successfully designed synthesized, which feature NLO-active [B5O10] groups [Y/LuO6] polyhedra. They exhibit notably short UV absorption cutoff...
Birefringent materials, capable of manipulating light polarization, are pivotal in advanced optical technologies. Traditionally, the development such materials has predominantly focused on purely inorganic compounds, which often exhibit limited birefringence. Herein, we present a new 3-pyridinesulfonate birefringent crystal, Ca(3-C5H4NSO3)2·4H2O, synthesized via hydrogen-bonded regulation strategy designed to enhance coplanarity [3-pySO3] groups. As expected, Ca(3-C5H4NSO3)2·4H2O...
Mutations in POLG, encoding POLγA, the catalytic subunit of mitochondrial DNA polymerase, cause a spectrum disorders characterized by mtDNA instability. However, molecular pathogenesis POLG-related diseases is poorly understood and efficient treatments are missing. Here, we generate PolgA449T/A449T mouse model, which reproduces A467T change, most common human recessive mutation POLG. We show that A449T impairs binding synthesis activities POLγ, leading to stalling phenotype. Most...
Abstract Aim To explore the mechanism of healing tendon tissue and anti-adhesion, to discuss role transforming growth factor-β3 (TGF-β3)/cAMP response element binding protein-1 (CREB-1) signaling pathway in process tendons. Method All mice were divided into four groups 1, 2, 4, 8 weeks respectively. Each time group was treatment groups: amplification group, inhibition negative control group. When injury model established, CREB-1 virus injected parts. A series methods such as gait...
We present a mechanism of topological pumping in origami metamaterials with spatial modulation by tuning the rotation angles. Through coupling spatially modulated chains along an additional synthetic dimension, waves from one edge state to another is achieved, where Landau-Zener transition demonstrated varying number coupled chains. In addition, inherent nonlinearity enables excitation-dependent tunneling probability. Furthermore, increase nonlinearity, states tend localize several regions...
提供多种生态系统功能的能力, 即生态系统多功能性(ecosystem multifunctionality, EMF)。本文综述了EMF研究中功能指标的 选择、生物多样性的不同维度
Epidemiological evidence shows a robust relationship between cognitive dysfunction and type 2 diabetes mellitus (T2DM). This study identified major risk factors that might prevent or ameliorate T2DM-associated in the realm of clinical practice.Using Mini-mental State Examination (MMSE) light education level, we older adults with T2DM on admission aged 50 above. We conducted this case-control when eligible participants were divided into Cognitively Normal (CN) group Impaired (CI) group....
Elastic valley metamaterials offer an excellent platform to manipulate elastic waves and have potential applications in energy harvesting elastography. Here we introduce a series of strategies realize topological transition spiral by parameter modulations. We show the evolution Berry curvature Chern number as function inherent parameters spiral, which further results general scheme achieve edge states. Our strategy leverages multiple degrees freedom provide enhanced opportunities for desired
Abstract Coral reef ecosystems support significant biological activities and harbor huge diversity, but they are facing a severe crisis driven by anthropogenic climate change. An important behavioral trait of the coral holobiont is motion, which may play an essential role in feeding, competition, reproduction, thus survival fitness. Therefore, characterizing behavior through motion analysis will aid our understanding basic physical functions. However, tissue stony scleractinian corals that...
Tentacles on soft corals exhibit intriguing spatiotemporal dynamics of motions, which may benefit their survival and fitness. Despite significance, studies quantitative properties still remain challenging unexplored. Such motions are characterized by coherent patterns across both space time, yet computational methods that address rare. Here, we introduce a data-driven method called dynamic mode decomposition (DMD) to explore the behavior tentacles Anthelia glauca, where eight captured...
Recent advancements in topological metamaterials have unveiled fruitful physics and numerous applications. Whereas initial efforts focus on achieving topologically protected edge states through principles of structural symmetry, the burgeoning field now aspires to customize states, tailoring their emergence frequency. Here, our study presents realization phase transitions utilizing compliant mechanisms facets Miura-folded metamaterials. This approach induces two opposite phases, leading at...
Elastic topological states have been receiving increased attention in numerous scientific and engineering fields due to their defect-immune nature, resulting applications of vibration control information processing. Here, we present the data-driven discovery elastic using dynamic mode decomposition (DMD). The DMD spectrum modes are retrieved from propagation relevant along boundary, where nature is learned by DMD. Applications such as classification synthesis wave can be achieved underlying...