A5103248605- HER2/EGFR in Cancer Research
- Advanced Breast Cancer Therapies
- Lung Cancer Treatments and Mutations
- Ferroptosis and cancer prognosis
- Inflammatory Myopathies and Dermatomyositis
- Heterotopic Ossification and Related Conditions
- Venous Thromboembolism Diagnosis and Management
- Endoplasmic Reticulum Stress and Disease
- Monoclonal and Polyclonal Antibodies Research
- Peptidase Inhibition and Analysis
- Ovarian function and disorders
- Liver physiology and pathology
- RNA regulation and disease
- Lipid metabolism and disorders
- Advanced Neuroimaging Techniques and Applications
- Xenotransplantation and immune response
- Glioma Diagnosis and Treatment
- Wnt/β-catenin signaling in development and cancer
- Muscle Physiology and Disorders
- Inflammation biomarkers and pathways
- Nuclear Receptors and Signaling
- Cancer, Lipids, and Metabolism
- Blood Coagulation and Thrombosis Mechanisms
- Ion channel regulation and function
- Brain Metastases and Treatment
Wuhan No.1 Hospital
2021-2024
Tianjin Hospital
2024
The First People's Hospital of Changde
2022
Central South University
2022
The Central Hospital of Shaoyang
2020-2021
Beijing Shijitan Hospital
2020
Capital Medical University
2020
Binzhou People's Hospital
2017-2019
Air Force Medical University
2019
Xijing Hospital
2019
Patients with HER2-positive (HER2+) metastatic breast cancer (MBC) have poor prognoses. Pyrotinib has shown promising antitumor activity in MBC to improve progression-free survival (PFS). However, findings based on real-world data analyze whether pyrotinib affects overall (OS) remain scarce.This study is an exploratory analysis of brain metastasis (BM) and the final update our preceding 168 patients HER2+ MBC. PFS, OS, tumor mutation burden (TMB), clinical benefit rate (CBR), response (ORR)...
Background: Pyrotinib, an irreversible pan-ERBB inhibitor, has shown promising antitumour activity, and acceptable tolerability. This research was conducted to evaluate the actual use effectiveness of pyrotinib in China, therefore, contributed solve problem real-world data scarcity. Methods: In this retrospective study, 168 patients who received treatment for HER2-positive metastatic breast cancer (MBC) Hunan Province from June 2018 August 2019 were included. Progression-free survival (PFS),...
Pertuzumab plus trastuzumab combined with chemotherapy has become a standard neoadjuvant therapy option for patients high-risk human epidermal growth factor receptor 2 (HER2)-positive breast cancer (BC). There is still not enough evidence the efficacy and safety of pertuzumab in HER2-positive BC China, both clinical trials real-world settings. This study aimed to assess combination Chinese application.We retrospectively collected data from electronic medical records treated December 2018 May...
To investigate the role and mechanism of suppressor cytokine signaling 1 (SOCS1) in regulation differentiation C17.2 neural stem cells (NSCs).In this study, lentiviral (LV)-SOCS1-enhanced green fluorescent protein (EGFP) was constructed transfected into NSCs. There were three groups NSCs: LV-SOCS1-EGFP, LV-EGFP, phosphate-buffered saline (PBS). The expression levels microtubule-associated 2 (MAP2), glial fibrillary acidic (GFAP), myelin basic (MBP), nestin, β-tubulin III NSCs analyzed by...
Adenomyoepithelioma (AME) of the breast is a rare tumor that composed proliferating epithelial and myoepithelial cells. The pathogenesis AME remains unclear, no cancer cells have been identified in such tissues. In this study, we established patient-derived organoids from surgical samples an elderly Chinese woman with breast. Our findings confirmed successful establishment patient. A short tandem repeat analysis revealed DNA signature matched original specimen. Moreover, diameter assay...
We previously found that oxygen-glucose-serum deprivation/restoration (OGSD/R) induces apoptosis of spinal cord astrocytes, possibly via caspase-12 and the integrated stress response, which involves protein kinase R-like endoplasmic reticulum (PERK), eukaryotic initiation factor 2-alpha (eIF2α) activating transcription 4 (ATF4). hypothesized edaravone, a low molecular weight, lipophilic free radical scavenger, would reduce OGSD/R-induced astrocytes. To test this, we established primary...
Dermatomyositis (DM) and muscular dystrophy are clinically difficult to differentiate.To confirm the feasibility assess accuracy of conventional magnetic resonance imaging (MRI), T2 map, diffusion tensor (DTI), kurtosis (DKI) in differentiation DM from dystrophy.Forty-two patients with proven by diagnostic criteria were enrolled study along 23 dystrophy. Conventional MR, DTI, DKI images obtained thigh musculature for all patients. Intramuscular value, apparent coefficient (ADC), fractional...
Abstract Background Hepatocellular carcinoma (HCC) is a malignant tumor with significant variability in prognosis among patients. Ras‐related C3 botulinum toxin substrate 1 (RAC1) key focus the area of cancer research. However, molecular mechanisms RAC1 HCC remain incompletely elucidated. Materials and methods In this study, bioinformatics analysis was used, public databases were used to obtain information about cases. The samples categorized into two groups high low expression based on...
Background: Alcohol abuse, non-alcoholic fatty liver disease (NAFLD), and hepatitis B C are the main pathogenic factors of hepatocellular carcinoma (HCC). Though current understanding risk for HCC has been improved, patients with this type cancer normally diagnosed at advanced stages, posing significant challenges to effective treatment. Methods: This study analyzed datasets from The Cancer Genome Atlas (TCGA) Gene Expression Omnibus (GEO) database (GSE14520 GSE116174). Stromal immune cell...
<div>AbstractPurpose:<p>Patients with HER2-positive (HER2<sup>+</sup>) metastatic breast cancer (MBC) have poor prognoses. Pyrotinib has shown promising antitumor activity in MBC to improve progression-free survival (PFS). However, findings based on real-world data analyze whether pyrotinib affects overall (OS) remain scarce.</p>Experimental Design:<p>This study is an exploratory analysis of brain metastasis (BM) and the final update our preceding 168...
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Abstract BackgroundIn the glioma microenvironment, infiltrating immune cells has been shown to possess beneficial effects for tumor progression. Immune and stromal dominate microenvironment in glioma. The complex interplay between progression with or was still unknown. MethodsIn this study, we used Estimation of malignant tissues using expression data (ESTIMATE) calculations calculate proportion tumour-infiltrating (TIC) number components cases from cancer Genome Atlas (TCGA) Chinese Glioma...
Objective To study the curative effects of ethinylestradiol cyproterone acetate (Diane-35) combined with insulin sensitizer metformin (MTF) on clinical and biomedical manifestation for treating infertile patients polycystic ovary syndrome (PCOS) complicated resistance (IR).Methods A total 78 PCOS admitted to our hospital from July 2006 February 2013 were randomly divided into treatment group control group,with 39 cases in each group.The (n=39) was treated Diane-35 weight three months,the...
Aims In endoscopic surgery, the visual field is frequently obstructed by muscles, blood, and even smoke. To overcome this problem, we have developed a new detachable Gold-finger retractor for narrow-space surgery. Methods was used in 30 patients to facilitate surgical exposure smoke discharge, while 27 patients, percutaneous silk thread suspension employed same purpose. Both groups underwent unilateral thyroidectomy central lymph node dissection via oral vestibular microincision combined...