A5101673559- Pregnancy and preeclampsia studies
- MicroRNA in disease regulation
- Mosquito-borne diseases and control
- Insect symbiosis and bacterial influences
- Angiogenesis and VEGF in Cancer
- Cancer-related molecular mechanisms research
- Reproductive System and Pregnancy
- Wnt/β-catenin signaling in development and cancer
- Cerebrovascular and genetic disorders
- Autoimmune and Inflammatory Disorders Research
- Insect Pest Control Strategies
- Phytochemistry and Biological Activities
- Spondyloarthritis Studies and Treatments
- Genetic factors in colorectal cancer
- Lung Cancer Treatments and Mutations
- Wound Healing and Treatments
- Ion channel regulation and function
- Alzheimer's disease research and treatments
- Insect Resistance and Genetics
- Inflammasome and immune disorders
- Invertebrate Immune Response Mechanisms
- Melanoma and MAPK Pathways
- Fibroblast Growth Factor Research
- Cancer-related gene regulation
- Endoplasmic Reticulum Stress and Disease
China Medical University
2019-2021
Nanjing Medical University
2017-2021
Institute of Microbiology
2016-2019
Changzhou No.2 People's Hospital
2019
Huazhong University of Science and Technology
2012-2014
Union Hospital
2014
Molina Center for Energy and the Environment
2012
Abstract Preeclampsia is a specific vascular complication in pregnancy, which has pathophysiology of altered endothelial homeostasis. There extensive evidence that progenitor cells (EPCs) dysfunction underlies the loss occurs during preeclampsia. MicroRNA‐126 (miR‐126), an angiogenesis‐related miRNA, been shown to have potential angiogenic effects both cultured vitro and ischemia‐induced angiogenesis vivo. However, whether miR‐126 therapeutic placental vasculogenesis preeclampsia remains...
Being one of the hallmarks Alzheimer's disease, β-amyloid (Aβ) aggregates induce complicated neurotoxicity. Evidences show that underlying mechanism neurotoxicity involves a glutamate receptor subtype, N-methyl-D-aspartate (NMDA) receptor, an increase in intracellular calcium( II) ion loading as well elevation oxidation stress. In this work, among 35 chemical components Chinese herbal medicines (CHMs) being screened for inhibitors Aβ aggregation, four them, namely albiflorin, aloeemodin,...
Tumor microenvironment interacts with gastric cancer (GC) cells and affects tumor development.The communication between GC fibroblasts has not been clearly studied understood.MiR-10b-5p was found highly expressed in tissue serum samples of patients advanced stages (stage III+IV) than that early stage I+II).The expression determination exosomal microRNA also shown high miR-10b-5p stages.Dual-luciferase activity assays indicated targeted PTEN KLF11 fibroblasts.The silence up-regulated the...
Culex pipiens pallens and Cx. p. quinquefasciatus are important vectors of many diseases, such as West Nile fever lymphatic filariasis. The widespread use insecticides to control these disease other insect pests has led insecticide resistance becoming common in species. In this study, high throughout Illumina sequencing was used identify hundreds genes that were differentially expressed response exposure. identification is a vital first step for more detailed investigation the molecular...
The formin protein dishevelled-associated activator of morphogenesis 1 (DAAM1) polymerizes straight actin filaments and mediates migration cancer cells. However, how DAAM1 governs cell haptotaxis in response to collagen remains unexplored breast We hypothesized that invadopodia extension type IV association with integrin receptors. Using Boyden chamber membranes coated collagen, we show here activates both Ras homolog family member A (RHOA) promotes MDA-MB-231 MDA-MB-453 cells, a process...
The midgut is the first barrier to dengue virus (DENV) infections of mosquitoes and therefore a major bottleneck for subsequent development vector competence. However, molecular mechanisms responsible this are unknown. We constructed three small RNA libraries from midguts adult Aedes albopictus females that had been fed on either sugar solution, an uninfected blood meal, or meal infected with DENV-2, and112 conserved microRNAs represented by 173 miRNA sequences were identified, 34 novel...
The mosquito Aedes albopictus is an important vector for dengue virus (DENV) transmission. midgut the first barrier to infection by DENV, and this a critical factor affecting competence of mosquito. However, molecular mechanism interaction between unknown.Six small libraries Ae. RNAs were constructed, three which from mosquitoes that infected with DENV-2 after feeding on blood, another remained uninfected same batch blood. A total 46 differentially expressed miRNAs identified 17 significant...
Pre-eclampsia (PE) is a specific vascular complication in pregnancy whose precise mechanism still unclear. We hypothesized that endothelial progenitor cells (EPCs), the precursor of cells, might be impaired patients with PE and hold great promise for treatment PE. In present study, we analyzed EPCs number expression integrin-linked kinase (ILK) patients. confirmed both ILK were diminished Next, transfected gene using ultrasonic microbubble technique (UMT) first time, as UMT novel type...
Odorant binding proteins (OBPs) play a critical role in mediating mosquito behaviors. In the current study, four AealOBP genes were cloned and sequenced. Basic Local Alignment Search Tool Program phylogenetic analysis of deduced amino acid sequences identified unique putative ortholog Aedes aegypti (L.) for each albopictus (Skuse) OBP. Quantitative showed some AealOBPs with strong female/male expression ratio, which we proposed to be involved host seeking female mosquitoes. Other OBPs are...
Moyamoya disease (MMD) is a progressive stenosis at the terminal portion of internal carotid artery and frequently occurs in East Asian countries. The etiology MMD still largely unknown. We performed case-control design with whole-exome sequencing analysis on 31 sporadic patients 10 normal controls matched age gender. Patients clinically diagnosed was determined by digital subtraction angiography (DSA). Twelve predisposing mutations seven genes associated Chinese ancestry ( CCER2, HLA-DRB1,...
Problem The effect of IFN ‐γ on the expression osteopontin ( OPN ), in presence or absence 1α,25‐dihydroxyvitamin D3 (1,25( OH ) 2 D 3 decidual stromal cells DSC ). Method study Decidual were isolated from women undergoing elective termination pregnancy (gestational age, 6–9 weeks). After characterization, they treated with 1,25( . uterus knockout mice collected gestation day (gd) 7.5, and examined. Results drastically decreased , which was reverted by addition to ‐γ‐treated cells. Moreover,...
We previously found that oxygen-glucose-serum deprivation/restoration (OGSD/R) induces apoptosis of spinal cord astrocytes, possibly via caspase-12 and the integrated stress response, which involves protein kinase R-like endoplasmic reticulum (PERK), eukaryotic initiation factor 2-alpha (eIF2α) activating transcription 4 (ATF4). hypothesized edaravone, a low molecular weight, lipophilic free radical scavenger, would reduce OGSD/R-induced astrocytes. To test this, we established primary...
Objective To investigate the role of microRNA (miR)-126 in pathogenesis preeclampsia.Methods From November 2011 to April 2012,20 healthy pregnant women and 24 with preeclampsia underwent cesarean section Union Hospital Tongji Medical College were selected.Umbilical venous blood was taken endothelial progenitor cells (EPCs) separated cultured.Reverse transcription-polymerase chain reaction (RT-PCR) used test level miR-126 cultured EPCs.EPCs from divided into study group,negative group control...