A5091415658- Cancer-related molecular mechanisms research
- Clostridium difficile and Clostridium perfringens research
- MicroRNA in disease regulation
- Gut microbiota and health
- Genetic and phenotypic traits in livestock
- Mycobacterium research and diagnosis
- Myasthenia Gravis and Thymoma
- Pharmacological Effects of Natural Compounds
- RNA modifications and cancer
- S100 Proteins and Annexins
- Circular RNAs in diseases
- Sepsis Diagnosis and Treatment
- Peripheral Neuropathies and Disorders
- Photosynthetic Processes and Mechanisms
- Hedgehog Signaling Pathway Studies
- Microbial infections and disease research
- Animal Disease Management and Epidemiology
- Antifungal resistance and susceptibility
- Genomics and Phylogenetic Studies
- Ginseng Biological Effects and Applications
- Plant Molecular Biology Research
- Toxic Organic Pollutants Impact
- Air Quality and Health Impacts
- Salivary Gland Tumors Diagnosis and Treatment
- Galectins and Cancer Biology
Shandong Agricultural University
2021-2025
Gansu Agricultural University
2016-2025
Cancer Genetics (United States)
2024-2025
Chinese Academy of Medical Sciences & Peking Union Medical College
2025
Tianjin First Center Hospital
2025
Tianjin Medical University
2024-2025
Chengdu Research Base of Giant Panda Breeding
2013-2025
Columbia University
2024-2025
Beijing University of Chinese Medicine
2018-2024
Chinese Academy of Agricultural Sciences
2022-2024
Diarrhea is a leading cause of increased mortality in neonatal and young piglets. Aberration the gut microbiota one important factor etiology piglet diarrhea. However, information regarding structure function microbiome diarrheic piglets limited. To investigate composition functional potential fecal piglets, we performed 16S rRNA gene sequencing on 20 samples from healthy controls, metagenomics subset six samples. We found striking compositional differences between Neonatal diarrhea was...
Abstract The significant function of circRNAs in cancer was recognized recent work, so a well-organized resource is required for characterizing the interactions between and other functional molecules (such as microRNA RNA-binding protein) cancer. We previously developed cancer-specific circRNA database (CSCD), comprehensive circRNAs, which widely used research. Here, we updated CSCD to CSCD2 (http://geneyun.net/CSCD2 or http://gb.whu.edu.cn/CSCD2), includes significantly more identified from...
Abstract To fully unlock the potential of pigs as both agricultural species for animal-based protein food and biomedical models human biology disease, a comprehensive understanding molecular cellular mechanisms underlying various complex phenotypes in how findings can be translated to other species, especially humans, are urgently needed. Here, within Farm animal Genotype-Tissue Expression (FarmGTEx) project, we build PigBiobank (http://pigbiobank.farmgtex.org) systematically investigate...
Abstract Poly-ADP-ribose polymerases 1 and 2 (PARP1 2) are critical sensors of DNA-strand breaks targets for cancer therapy. Upon DNA damage, PARP1 synthesize poly-ADP-ribose (PAR) chains on themselves other substrates, facilitating single-strand break repair by recruiting PAR-binding factors, including X-ray cross-complementing group (XRCC1) aprataxin polynucleotide kinase phosphatase-like factor (APLF). While diverse lesions activate PARP1, PARP2 is selectively activated 5′ phosphorylated...
Notch1 regulates tumor biology in a complex, context-dependent manner. The roles of tongue cancer are still controversial. aim this study is to investigate the cancer.The expression was tested between and normal samples by using immunohistochemistry. Tongue cells were transfected with siRNA or plasmid, respectively. Cell proliferation, apoptosis, migration invasion ability appropriate ways. subcutaneous model established observe growth.Notch1 upregulated carcinoma tissues related stage...
Diarrhea is one of the most common enteric diseases in young piglets. Diverse factors such as an unstable gut microenvironment, immature intestinal immune system, early supplementary feeding, and weaning often induce dysfunction microbiota, thus leading to a continuing high incidence diarrhea However, few studies have characterized microbiota diarrheic piglets following changes diet during development physiology. In this study, we used 16S rRNA gene sequencing analyze dynamic establishment...
Intestinal ischemia–reperfusion (I/R) injury is a serious disease in medical settings, and gut dysbiosis major contributor to its development. Polysaccharides from Agaricus blazei Murill (ABM) showed range of pharmacological activities, yet no studies assessed the potential ABM polysaccharides for alleviating intestinal I/R injury. Here, we purified polysaccharide (ABP1) an fruit body subsequently tested mitigate mouse model temporary superior mesenteric artery occlusion. The results reveal...
BackgroundEpidemiologic studies suggest that there may be an association between environmental exposure to persistent organic pollutants (POPs) and diabetes.ObjectiveThe aim of this study was test the hypothesis residential proximity POP-contaminated waste sites result in increased rates hospitalization for diabetes.MethodsWe determined number hospitalized patients 25–74 years age diagnosed with diabetes New York State exclusive City 1993–2000. Descriptive statistics negative binomial...
// Bo-Hua Su 1,* , Jing Qu Min Song Xiao-Yu Huang 1 Xiao-Meng Hu Jian Xie Yong Zhao 2 Lin-Can Ding Lin She Jiang Chen 3 Li-Song 4 Xu 5 Da-Li Zheng 5,6 and You-Guang Lu Department of Preventive Dentistry, Affiliated Stomatological Hospital, Fujian Medical University, Fuzhou, China Pathology, Center Dental Implant, Oral Maxillofacial Surgery, First Hospital Key Laboratory Ministry Education for Gastrointestinal Cancer, School Basic Sciences, 6 Molecular Oncology, Moffitt Cancer Center, Tampa,...
Summary Surface properties, such as adhesion and hydrophobicity, constrain dispersal of bacterial spores in the environment. In Bacillus subtilis , these properties are influenced by outermost layer spore, crust . Previous work has shown that two clusters, cotVWXYZ cgeAB encode protein components crust. Here, we characterize respective roles genes surface using Bacterial Adherence to Hydrocarbons assays, negative staining polysaccharides India ink Transmission Electron Microscopy. We showed...
Our previous study demonstrated a close relationship between the NOTCH signaling pathway and salivary adenoid cystic carcinoma (SACC).Its receptor gene, NOTCH1, its downstream HES1, contribute to proliferation, invasion metastasis of SACC.Accumulating evidence supports HEY1 as another effector pathway.The purpose this was explore effects NOTCH1-HEY1 on SACC cells.Our results verified that is specific molecular target in cells expression much higher than paracarcinoma tissues.The NOTCH1 are...
Abstract Higher dietary energy is often used to achieve better animal performance in mutton sheep production. Notably, changing the diet formula affects rumen fermentation and microbiota of ruminants. In this study, we investigated effect on ruminal fattening sheep. Fifteen 2-month-old white-headed Suffolk (♂) × Hu (♀) crossbred lambs were randomly divided into three treatments based feeds fed: 8.67 MJ/kg (Low (LE); n = 5), 10.38 (standard (CON); 12.31 (high (HE); 5) groups. After 70 days...
Previous investigations have illuminated the significant association between gut microbiome and a broad spectrum of health conditions, including obesity, diabetes, cardiovascular diseases, psychiatric disorders. Evidence from certain studies suggests that dysbiosis microbiota may play role in etiology obesity diabetes. Moreover, it is acknowledged dietary habits, pharmacological interventions, psychological stress, other exogenous factors can substantially influence microbial composition....
Breast milk, an indispensable source of immunological and nutrient components, is essential for the growth development newborn mammals. MicroRNAs (miRNAs) are present in various tissues body fluids selectively packaged inside exosomes, a type membrane vesicle. Milk exosomes have potential regulatory effects on growth, development, immunity piglets. To explore differences milk related to breed type, we isolated from colostrum mature domestic Bamei pigs foreign Landrace by using density...
In this study, we investigated the effects of dietary inclusion different proportions whole-plant corn silage on growth performance, serum biochemical indexes, and intestinal microorganisms in Hezuo pigs. Thirty-two two-month-old pigs (body weight: 7.88 ± 0.81 kg) were randomly divided into four groups eight (half male, half female) each. The control (CON) group received a basal diet, while three experimental fed part which had been replaced with 5%, 10%, 15% silage, respectively. experiment...
The extinction risk of the giant panda has been demoted from “endangered” to “vulnerable” on International Union for Conservation Nature Red List, but its habitat is more fragmented than ever before, resulting in 33 isolated populations according fourth national survey released by Chinese government. Further comprehensive investigations genetic background and in-depth assessments conservation status wild are still necessary urgently needed. Here, we sequenced genomes 612 pandas with an...
As a common kind of food, pepper is well known for its special effects on the physiological state human individuals. Capsaicin, main component pepper, speculated to be linked with intestinal microorganisms account their direct contact. Herein, we first utilized mouse models and 16S rRNA high-throughput sequencing compare differences in flora between groups without capsaicin treatment by gavage. The mice two showed significantly distinct performance terms body weight, leukocyte count, fecal...