A5101927716- CAR-T cell therapy research
- CRISPR and Genetic Engineering
- Pluripotent Stem Cells Research
- Transplantation: Methods and Outcomes
- Immune Cell Function and Interaction
- Renal Transplantation Outcomes and Treatments
- Viral Infectious Diseases and Gene Expression in Insects
- T-cell and B-cell Immunology
- Immunotherapy and Immune Responses
- Tissue Engineering and Regenerative Medicine
- Pancreatic function and diabetes
- Phagocytosis and Immune Regulation
- RNA Interference and Gene Delivery
- Cardiac Structural Anomalies and Repair
- Oral and Maxillofacial Pathology
- Tumors and Oncological Cases
- Antioxidant Activity and Oxidative Stress
- Salivary Gland Tumors Diagnosis and Treatment
- Diabetes Management and Research
- Tuberculosis Research and Epidemiology
- Mechanical Circulatory Support Devices
- Monoclonal and Polyclonal Antibodies Research
- Organ Transplantation Techniques and Outcomes
- Multiple Myeloma Research and Treatments
- Silicon Carbide Semiconductor Technologies
Yili Normal University
2023-2025
Huzhou University
2025
International Bamboo and Rattan Organization
2024
State Forestry and Grassland Administration
2024
Sana Biotechnology (United States)
2021-2024
University of California, San Francisco
2017-2024
Wuhan Pulmonary Hospital
2021-2022
Tianjin Medical University Cancer Institute and Hospital
2022
University Medical Center Hamburg-Eppendorf
2014-2021
German Centre for Cardiovascular Research
2014-2021
Here we report on the existence and functionality of immune checkpoint signal regulatory protein α (SIRPα) in NK cells describe how it can be modulated for cell therapy. SIRPα is up-regulated upon IL-2 stimulation, interacts with target CD47 a threshold-dependent manner, counters other stimulatory signals, including IL-2, CD16, or NKG2D. Elevated expression protected K562 tumor mouse human MHC class I–deficient against SIRPα+ primary cells, but not SIRPα− NKL NK92 cells. deficiency antibody...
Abstract Genetic engineering of allogeneic cell therapeutics that fully prevents rejection by a recipient’s immune system would abolish the requirement for immunosuppressive drugs or encapsulation and support large-scale manufacturing off-the-shelf products. Previously, we generated mouse human hypoimmune pluripotent (HIP) stem cells depleting HLA class I II molecules overexpressing CD47 ( B2M −/− CIITA + ). To determine whether this strategy is successful in non-human primates, engineered...
Transplantation of allogeneic pancreatic donor islets has successfully been performed in selected patients with difficult-to-control insulin-dependent diabetes and impaired awareness hypoglycemia (IAH). However, the required systemic immunosuppression associated this procedure prevents cell replacement therapy from more widespread adoption larger patient populations. We report editing primary human islet cells to hypoimmune HLA class I- II-negative CD47-overexpressing phenotype their...
Manufacturing autologous chimeric antigen receptor (CAR) T cell therapeutics is complex, and many patients experience treatment delays or cannot be treated at all. Although current allogeneic CAR products have the potential to overcome manufacturing bottlenecks, they are subject immune rejection failure persist in host, thus do not provide same level of efficacy as their counterparts. Here, we aimed develop universal cells that evade system produce a durable response. We generated human...
Allogeneic transplantation of pancreatic islets for patients with difficult-to-control diabetes mellitus is severely hampered by the requirement continuous immunosuppression and its associated morbidity. We report that allogeneic genetically engineered (B2M−/−, CIITA−/−, CD47+), primary, hypoimmune, pseudo-islets (p-islets) results in their engraftment into a fully immunocompetent, diabetic non-human primate wherein they provide stable endocrine function enable insulin independence without...
Abstract Effective strategies for hepatocellular carcinoma, which is the second leading cause of death worldwide, remain limited. A growing body emerging evidence suggests that ferroptosis activation a novel promising approach treatment this malignancy. Nevertheless, potential therapeutic targets and molecular mechanisms elusive. In study, we found PNO1 bona fide inhibitor autophagy induced by promotes cystine/glutamate antiporter SLC7A11 while increasing synthesis accumulation intracellular...
// Bo-Hua Su 1,* , Jing Qu Min Song Xiao-Yu Huang 1 Xiao-Meng Hu Jian Xie Yong Zhao 2 Lin-Can Ding Lin She Jiang Chen 3 Li-Song 4 Xu 5 Da-Li Zheng 5,6 and You-Guang Lu Department of Preventive Dentistry, Affiliated Stomatological Hospital, Fujian Medical University, Fuzhou, China Pathology, Center Dental Implant, Oral Maxillofacial Surgery, First Hospital Key Laboratory Ministry Education for Gastrointestinal Cancer, School Basic Sciences, 6 Molecular Oncology, Moffitt Cancer Center, Tampa,...
Significance Precise gene editing allows engineering of immune receptors and ligands to reduce the immunogenicity cells, strategies for generation immune-evasive stem cell sources are currently being developed. This article describes translational aspect generating universally transplantable, disease-specific, therapeutic products. We provide proof concept that immune-engineered cells can treat major cardiovascular pulmonary diseases in fully allogeneic subjects without utilizing any...
Green tea and its active extracts have been widely used in a variety of dietary supplements. However, to date, the interaction these bioactive compounds green their protein targets are not well studied. We first bioinformatics analysis relevant diabetes-related with target proteins construct (PPI) network screen core targets. The results vitro experiments showed that EGCG, major polyphenolic component tea, inhibited HG-induced cardiomyocyte hypertrophy, inflammation, oxidative stress...
The Homeobox (HOX) gene family are conserved transcription factors that essential for embryonic development, oncogenesis, and cancer suppression in biological beings. Abnormally expressed HOX genes cancers directly associated with prognosis. Public databases such as TCGA the R language were used to perform pan-cancer analyses of terms expression, prognosis, immune microenvironment. score was defined, potential target compounds predicted by Connective Map. Immunohistochemistry employed...
To evaluate the ability to depict anatomy and complications of renal vascular transplant with unenhanced magnetic resonance (MR) angiography spatial labeling multiple inversion pulses (SLEEK) compare results color Doppler (CD) ultrasonography (US), digital subtraction (DSA), intraoperative findings.This study was approved by institutional review board, written informed consent received before examination. Seventy-five patients who underwent transplantation were examined MR SLEEK CD US. DSA...
Diabetes mellitus (DM), a common tuberculosis (TB) comorbidity, is associated with delayed bacillary clearance during anti-TB treatment and unfavorable outcomes. Bedaquiline (BDQ), when used as part of multidrug regimen for multidrug-resistant/extensively drug-resistant (MDR/XDR-TB), has been shown to be effective safe although outcome risks patients MDR/XDR-TB DM are unknown. A multicenter retrospective study was conducted compared the safety effectiveness 24-week BDQ-containing without DM....
FliD and CagA are important virulence factors of H. pylori. We aimed to evaluate the screening values for gastric cancer (GC). Serum samples were obtained from 232 cases 266 controls in a case-control study. Unconditional multivariate logistic regression with odds ratios (ORs) 95% confidence intervals (CIs) was used analyze relationships between FliD, GC. The sensitivities, specificities receiver operating characteristic (ROC) curves calculated. Finally, combined FlaA, NapA assessed based on...
Previous studies have reported that inhibitor of DNA binding 1 (ID1) exerts an oncogenic role in a number tumors. In the present study, ID1 growth, invasion and migration salivary adenoid cystic carcinoma (SACC) cells was investigated. expression clinical SACC samples compared with normal tissues using immunohistochemical staining, correlation between pathological characteristics then determined. Subsequently, overexpressed or silenced to investigate effects on cell proliferation, migration....
Background Paphiopedilum armeniacum ( P. ), an ornamental plant native to China, is known for its distinctive yellow blossoms. However, the mechanisms underlying flower coloration remain unclear. Methods We selected samples from different flowering stages and conducted rigorous physicochemical analyses. The specimens were differentiated based on their chemical properties, specifically solubilities in polar solvents. This key step enabled us identify main metabolite of color development ,...
Pluripotent stem cells are promising candidates for cell-based regenerative therapies. To avoid rejection of transplanted cells, several approaches being pursued to reduce immunogenicity the or modulate recipient's immune response. These include gene editing antigenicity cell products, immunosuppression host, using major histocompatibility complex-matched from banks. In this context, we have investigated H-Y antigens, a class minor antigens encoded by Y chromosome, assess whether gender...
The use of animal models is essential for developing new therapeutic strategies acute coronary syndrome and its complications. In this article, we demonstrate a murine cryoinjury infarct model that generates precise sizes with high reproducibility replicability. brief, after intubation sternotomy the animal, heart lifted from thorax. probe handheld liquid nitrogen delivery system applied onto myocardial wall to induce cryoinjury. Impaired ventricular function electrical conduction can be...
Linezolid (LZD) is an effective drug in treating multidrug-resistant tuberculosis and extensively drug-resistant tuberculosis. This study aimed to evaluate the safety of LZD treatment patients with rifampicin resistant was a multicenter retrospective study. A total 184 treated from Jan 2018 Apr 2020 three hospitals were involved, their clinical symptoms recorded analyzed. Meanwhile, types incidence adverse effects associated evaluated. It showed that peripheral neuritis (51, 27.7%)...