A5112008093- Wound Healing and Treatments
- Dermatologic Treatments and Research
- Mesenchymal stem cell research
- Autophagy in Disease and Therapy
- Electrospun Nanofibers in Biomedical Applications
- Cancer-related gene regulation
- Endoplasmic Reticulum Stress and Disease
- Burn Injury Management and Outcomes
- Laser Applications in Dentistry and Medicine
- Mitochondrial Function and Pathology
- TGF-β signaling in diseases
- Periodontal Regeneration and Treatments
- NF-κB Signaling Pathways
- Phagocytosis and Immune Regulation
- Adipokines, Inflammation, and Metabolic Diseases
- Epigenetics and DNA Methylation
- Air Quality and Health Impacts
- Nanoparticles: synthesis and applications
- Antimicrobial agents and applications
- Calcium signaling and nucleotide metabolism
- Cannabis and Cannabinoid Research
- Immunotherapy and Immune Responses
- Bone Metabolism and Diseases
- Tissue Engineering and Regenerative Medicine
- Alzheimer's disease research and treatments
Southwest Hospital
2016-2025
Army Medical University
2016-2025
Capital Medical University
1998-2024
Guangzhou University of Chinese Medicine
2021-2024
Air Force Engineering University
2018
Southwest General Health Center
2017
United States Census Bureau
2017
University of Toledo
2016
Cleveland Clinic
2010-2015
Yale University
2007
BACE1 is required for the release of β-amyloid (Aβ) <i>in vivo</i>, and inhibition activity targeted reducing Aβ generation in Alzheimer9s patients. To further our understanding safe use inhibitors human patients, we aimed to study physiological functions by characterizing BACE1-null mice. Here, report finding spontaneous behavioral seizures Electroencephalographic recordings revealed abnormal spike-wave discharges mice, kainic acid-induced also occurred more frequently mice compared with...
Autologous platelet-rich plasma (PRP) has been suggested to be effective for wound healing. However, evidence its use in patients with acute and chronic wounds remains insufficient. The aims of this study were comprehensively examine the effectiveness, synergy possible mechanism PRP-mediated improvement skin repair.Full-thickness made on back C57/BL6 mice. PRP or saline solution as a control was administered area. Wound healing rate, local inflammation, angiogenesis, re-epithelialization...
Coronavirus disease 2019 (COVID-19) outbroke in Wuhan, China December and the severe acute respiratory syndrome (SARS) Guangzhou, 2003 were caused by highly pathogenic coronaviruses with high homology. Since novel coronavirus is contagious spreads rapidly. It has negative social effects massive economic loss globaly. Currently there no vaccine or effective drugs. Pulmonary fibrosis a pulmonary progressive fibrosis, which main factor leading to dysfunction declined quality of life SARS...
Abstract PTEN-induced kinase-1 (PINK1) is a crucial player in selective clearance of damaged mitochondria via the autophagy-lysosome pathway, process termed mitophagy. Previous studies on PINK1 mainly focused its post-translational modifications, while transcriptional regulation much less understood. Herein, we reported novel mechanism control transcription by SMAD Family Member 3 (SMAD3), an essential component transforming growth factor beta (TGFβ)-SMAD signaling pathway. First, observed...
Developing an ideal wound dressing that meets the multiple demands of good biocompatibility, appropriate porous structure, superior mechanical property and excellent antibacterial activity against drug-resistant bacteria is highly desirable for clinical care. Biocompatible thermoplastic polyurethane (TPU) membranes are promising candidates as a scaffold; however, their lack suitable structure has limited application. Antibiotics generally used preventing bacterial infections, but global...
Epidermal stem cells (EpSCs) that reside in cutaneous hair follicles and the basal layer of epidermis are indispensable for wound healing skin homeostasis. Little is known about effects photochemical activation on EpSC differentiation, proliferation migration during healing. The present study aimed to determine photodynamic therapy (PDT) vivo vitro.We created mouse full-thickness resection models applied 5-aminolevulinic acid (ALA) PDT beds. Wound was analysed by gross evaluation...
The core catalytic unit of telomerase comprises reverse transcriptase (TERT) and RNA (TERC). Unlike TERT, which is predominantly expressed in cancer stem cells, TERC ubiquitously normal somatic cells without activity. However, the functions these telomerase-negative remain elusive. Here, we reported positive feedback regulation between PI3K-AKT pathway that controlled cell proliferation independent activity human fibroblasts. Mechanistically, revealed activated transcription target genes...
The mammalian Atg18 ortholog WIPI2 is a key regulator of LC3 lipidation to promote autophagosome biogenesis during nonselective macroautophagy, while its functions in selective autophagy such as mitophagy remain largely unexplored. In this study, we explored the role PINK1-PRKN/parkin-mediated mitophagy. First, found that recruited damaged mitochondria upon induction. Second, loss impedes mitochondrial damaging agents-induced Third, at molecular level, binds and promotes AAA-ATPase VCP/p97...
Vasoactive intestinal peptide (VIP) was reported to promote angiogenesis. Electrospun nanofibers lead idea wound dressing substrates. Here we report a convenient and novel method produce VIP loaded microspheres in polycaprolactone (PCL) nanofibrous membrane without complicated processes. We first coated mussel-inspired dopamine (DA) nanofibers, then used strong adhesive DA absorb the functional peptide. PCL immersed into acetone generate with loading. employed high pressure liquid...
As a potential clinical therapeutic cell for injured tissue repair, mesenchymal stem cells (MSCs) have attracted increasing attention. Enhancing the pro-healing function of MSCs has gradually become an essential topic in improving efficacy MSCs. Recently, studies shown that neuronal protein 3.1 (P311) plays crucial role promoting skin wound healing, suggesting P311 gene modification may improve In this study, we demonstrated vivo expression could significantly enhance ability to lessen...
Eukaryotic initiation factor 6 (eIF6) is a pivotal regulator of ribosomal function, participating in translational control. Previously our data suggested that eIF6 acts as key binding protein P311 (a hypertrophic scar-related protein; also known NREP). However, comprehensive investigation its functional role and the underlying mechanisms modulation myofibroblast effector scar formation) differentiation remains unclear. Here, we identified novel transforming growth factor-β1 (TGF-β1)...
Qingre Huoxue Decoction (QRHX) is a classical Chinese herbal prescription widely used in clinical practice for the treatment of atherosclerosis (AS). Our previous study demonstrated its efficacy stabilizing plaque and improving prognosis, as well ability to regulate macrophage polarization. This aimed further investigate effects QRHX on AS explore underlying mechanisms.
Background Deng's Yangxin Decoction (DYX) is a Chinese herbal formula used in clinical practice to treat patients with myocardial infarction (MI). However, its underlying mechanism remains unclear. Objective This study aims explore potential biomarkers and associated mechanisms of DYX for MI. Methods Therapeutic targets were obtained based on the Traditional Medicine Systems Pharmacology Database Analysis Platform, Integrated Database, UniProt databases. Key screened using topological...
Abstract: Bacterial infection is a major hurdle to wound healing, and the overuse of antibiotics have led global issue, such as emergence multidrug-resistant bacteria, even "super bacteria". On contrary, nanosilver (NS) can kill bacteria without causing resistant bacterial strains. In this study, NS was simply generated in situ on polycaprolactone (PCL) nanofibrous mesh using an environmentally benign mussel-inspired dopamine (DA). Scanning electron microscopy showed that uniformly formed...