A5100767257- Rheumatoid Arthritis Research and Therapies
- Systemic Lupus Erythematosus Research
- Inflammasome and immune disorders
- Immune Response and Inflammation
- Spondyloarthritis Studies and Treatments
- Bariatric Surgery and Outcomes
- Immune Cell Function and Interaction
- Cytokine Signaling Pathways and Interactions
- Viral Infections and Immunology Research
- Vitamin C and Antioxidants Research
- Psoriasis: Treatment and Pathogenesis
- Autoimmune and Inflammatory Disorders Research
- Esophageal Cancer Research and Treatment
- T-cell and B-cell Immunology
- Monoclonal and Polyclonal Antibodies Research
- Cell death mechanisms and regulation
- Liver Disease Diagnosis and Treatment
- Osteoarthritis Treatment and Mechanisms
- Vitamin D Research Studies
- IL-33, ST2, and ILC Pathways
- T-cell and Retrovirus Studies
- Acute Lymphoblastic Leukemia research
- Cancer-related molecular mechanisms research
- Pharmacological Effects of Natural Compounds
- Traditional Chinese Medicine Analysis
Changzhou No.2 People's Hospital
2014-2024
Nanjing Medical University
2014-2024
Jiangsu Province Hospital
2019-2023
Guangzhou University of Chinese Medicine
2007-2023
Guangdong Pharmaceutical University
2023
Beijing Research Institute of Uranium Geology
2016-2023
Henan Agricultural University
2023
Xi’an Children’s Hospital
2021-2022
Dalian Medical University
2022
Xi'an Jiaotong University
2021
Chondrocyte apoptosis is considered one of the pathogenic factors osteoarthritis (OA), but its importance in pathogenesis OA remains unclear. Recent research adds progress to knowledge that mitochondrial signaling pathway mediates chondrocyte OA.Rat exposed H2O2 was used as experimental oxidative stress model. viability tested by cell counting kit-8 (CCK-8) assay. Cell and ROS were flow cytometry. Contents malondialdehyde (MDA), catalase (CAT), caspase-3, caspase-9, cytochrome C, superoxide...
The synthetic receptor 1 binds a variety of peptides and glycosides with high selectivity for functionality stereochemistry. Depending upon peptide mainchain substitutents, either the C- or N-terminus may be directed into binding pocket 1.
Biochemical and genetic experiments were carried out to deduce the structural functional domains of SopB protein involved in equipartition F plasmid. The is dimeric. Proteolytic chemical footprinting studies support earlier analyses that binding specific sites within plasmid <i>sopC</i> locus involves mainly C-terminal region. <i>In vivo</i>, expression a high level known repress <i>sopC</i>-linked genes. This silencing activity shown be unaffected by deletion 35 N-terminal residues, but...
Peptidylarginine deiminase type 4 (PADI4) and methyl-CpG binding domain (MBD4) are closely related with rheumatoid arthritis (RA). We hypothesized that PADI4 MBD4 polymorphisms may contribute to RA susceptibility.We studied rs2240340 G/A, rs874881 C/G, rs140693 rs2005618 T/C gene in 329 patients 697 controls a Chinese population. Genotyping was done using matrix-assisted laser desorption/ionization time-of-flight mass spectrometry (MALDI-TOF MS).When the GG homozygote genotype used as...
Background: Rheumatoid arthritis (RA) is related to several pivotal susceptibility genes, including cytotoxic T-lymphocyte-associated protein 4 (CTLA-4) and costimulatory molecule (CD80/CD86) genes. Although the connection between polymorphisms of CTLA-4 CD86 genes in different populations RA have been studied extensively, results are controversial. Objective: To clarify correlation Chinese Han population CTLA-4, CD80/86 , CD28 gene polymorphisms, susceptibility. Methods: A case-control...
To investigate the association between gastric cardiac adenocarcinoma (GCA) and six functional single nucleotide polymorphisms (SNPs) including interleukin 1A (IL1A) rs1800587 C>T, IL1B rs16944 G>A, IL1f7 rs3811047 IL3 rs40401 rs2073506 IL7Rα rs6897932 A>G. We performed a hospital-based case-control study to evaluate genetic effects of these SNPs. A total 243 GCA cases 476 controls were enrolled in this study. custom-by-design 48-Plex SNPscan(TM) kit was used determine genotypes. The G>A...
Gastric cardia adenocarcinoma (GCA) is one of the most common malignant tumors. In addition to environmental risk factors, genetic factors might play an important role in GCA carcinogenesis. To evaluate association between polymorphisms interleukin 17A (IL17A) gene on development GCA, we conducted a hospital-based case–control study. A total 243 cases and 476 controls were recruited their genotypes determined using custom-by-design 48-Plex SNPscan™ Kit. IL17A rs3819024 > G polymorphism was...
Objective Esophageal cancer was the fifth most commonly diagnosed and fourth leading cause of cancer-related death in China 2009. Genetic factors might play an important role esophageal squamous cell carcinoma (ESCC) carcinogenesis. Designs Methods To evaluate effect p21, p53, TP53BP1 p73 single nucleotide polymorphisms (SNPs) on risk ESCC, we conducted a hospital based case–control study. A total 629 ESCC cases 686 controls were recruited. Their genotypes determined using ligation detection...
Esophageal cancer was the fifth most commonly diagnosed and fourth leading cause of cancer-related death in China 2009. Genetic factors might play an important role carcinogenesis esophageal squamous cell carcinoma (ESCC). We conducted a hospital-based case-control study to evaluate ten NAT2 tagging single nucleotide polymorphisms (SNPs) on risk ESCC. Six hundred twenty-nine ESCC cases 686 controls were recruited. Their genotypes determined using ligation detection reaction method. In locus...