A5046792380- Cancer-related molecular mechanisms research
- Adipose Tissue and Metabolism
- Thyroid and Parathyroid Surgery
- Metabolomics and Mass Spectrometry Studies
- RNA modifications and cancer
- Fluid Dynamics and Mixing
- Innovative Microfluidic and Catalytic Techniques Innovation
- RNA Research and Splicing
- Mitochondrial Function and Pathology
- Vestibular and auditory disorders
- Hearing, Cochlea, Tinnitus, Genetics
- Sirtuins and Resveratrol in Medicine
- Tryptophan and brain disorders
- Nuclear reactor physics and engineering
- Metallurgical Processes and Thermodynamics
- Constraint Satisfaction and Optimization
- Circular RNAs in diseases
- Cellular Mechanics and Interactions
- Ferroptosis and cancer prognosis
- Heat transfer and supercritical fluids
- Polysaccharides and Plant Cell Walls
- Hippo pathway signaling and YAP/TAZ
- Connective tissue disorders research
- Meningioma and schwannoma management
- Geographic Information Systems Studies
University of Chinese Academy of Sciences
2020-2024
Shanghai Advanced Research Institute
2022-2024
Chinese Academy of Sciences
2020-2024
First Affiliated Hospital Zhejiang University
2024
Wuhan No.1 Hospital
2022-2024
Zhejiang University
2020-2023
Affiliated Hospital of Southwest Medical University
2023
Huadong Hospital
2022
Huazhong University of Science and Technology
2017-2022
Fudan University
2022
Background: Metastasis is the primary cause of death in colorectal cancer (CRC); underlying mechanisms remain partly unknown. In this study, we aim to investigate value HOXA11-AS survival evaluation and potential role HOXA11-AS/miR-149-3p axis CRC metastasis. Methods: The expressions HOXA11-AS, both obtained samples adjacent noncancerous tissues, were analyzed evaluation. Competing endogenous RNAs (CeRNAs) Analysis employed reveal relationship between miR-149-3p. It was further confirmed by...
Breast cancer has become the most common female tumor in world. Although great progress been made past decade, treatment of advanced breast remains unsatisfactory. An increasing number reports have indicated that long non‑coding RNAs (lncRNAs) a pivotal role chemoresistance as potential oncogenes numerous types cancer. However, precise mechanisms underlying action lncRNAs resistance to chemotherapy yet be fully elucidated. In present study, function and molecular lncRNA TMPO‑antisense RNA 1...
Presbycusis (age-related hearing loss) is a potential risk factor for tinnitus and cognitive deterioration, which result in poor life quality. Presbycusis-related with impairment common phenotype the elderly population. In these subjects, central auditory system shows similar pathophysiological alterations as those observed Alzheimer's disease (AD), including cholinergic hypofunction, epileptiform-like network synchronization, chronic inflammation, reduced GABAergic inhibition neural...
Hepatocellular carcinoma (HCC) is a common malignancy that driven by multiple genes and pathways. The aim of this study was to investigate the role specific mechanism actin-interacting protein zyxin (ZYX) in HCC. We found expression ZYX significantly higher HCC tissues compared normal liver tissues. In addition, overexpression hepatoma cell lines (PLC/PRF/5, HCCLM3) enhanced their proliferation, migration invasion, whereas knockdown had opposite effects (SK HEP-1, Huh-7). Furthermore, change...
Object. Proliferation and invasion are typical characteristics of breast cancer (BC) cells. Long noncoding RNA NUTM2A-AS1 has been shown to be dysregulated in tumors. This research was explore the effect on proliferation BC cell lines. Method. Using tumor database (TCGA) analysis platform (GEPIA), expression cases compared with normal cases. In addition, Kaplan-Meier curve overall survival according various levels assessed. Then, we constructed a knockdown plasmid successfully reduced...
The Molten Salt Reactor (MSR), one of the six advanced reactor types 4th generation nuclear energy systems, has many impressive features including economic advantages, inherent safety and non-proliferation. This paper introduces a system analysis code named TREND, which is developed used for steady transient simulation MSRs. TREND calculates distributions pressure, velocity temperature single-phase flows by solving conservation equations mass, momentum energy, along with fluid state...
The 24th annual symposium of the International Isotope Society's United Kingdom Group took place at Møller Centre, Churchill College, Cambridge, UK on Friday 6th November 2015. meeting was attended by 77 delegates from academia and industry, life sciences, chemical, radiochemical scientific instrument suppliers. Delegates were welcomed Dr Ken Lawrie (GlaxoSmithKline, UK, chair IIS group). subsequent programme consisted oral presentations, short 'flash' presentations in association with...
To evaluate the protective effect of axillary channel-assisted (ACA) transoral endoscopic thyroidectomy vestibular approach on mental nerve.From August 2018 to December 2020, 126 cases thyroid micro-carcinoma patients who underwent were recruited retrospectively. Of those, 74 performed with ACA trans-oral (ACA_TOETVA) (V and A group), 52 received standard TOETVA group). On postoperative day 1 (POD1), nylon monofilament test numbness visual analogue scale score conducted severity within area,...
Abstract Microbubbles were applied for the first time to enhance aqueous biphasic hydroformylation of long‐chain alkenes. The gas–liquid–liquid multiphase was carried out using 1‐dodecene as model higher olefin and dihexadecyl dimethyl ammonium bromide (DDAB) surfactant. increasing liquid temperature resulted in increased mean bubble size total number, but this trend became inapparent at high temperatures due reduced viscosity. gas flow rate favorable increase interfacial area, thus leading...
Background: Irisin, exercise-inducible myokine, is proposed to interact with other tissues, such as fat and brain regulate the balance of metabolism, increase energy expenditure, weight loss neurogenesis. Here, we investigated age-related changes Irisin levels in CSF, relationship paired plasma adiposity. Methods: were measure cerebrospinal fluid (CSF) 77 normal human subjects (18 females 59 males, age from 17 82) by ELISA assays. Results: Using multiple linear regression analysis, found CSF...
Abstract Triple-negative breast cancer (TNBC) is the most aggressive subtype of with poor outcomes and lacks effective targeted therapies. We utilized epigenomic landscape, TCGA database clinical samples to show activation HJURP in TNBC, which associated prognosis, metastasis, advanced stage. RNA-seq analysis silencing induced malignant phenotypes-related transcriptional signatures TNBC. Specifically, knock-down suppressed cell proliferation, migration, invasion, EMT progress, apoptosis...
Aims In endoscopic surgery, the visual field is frequently obstructed by muscles, blood, and even smoke. To overcome this problem, we have developed a new detachable Gold-finger retractor for narrow-space surgery. Methods was used in 30 patients to facilitate surgical exposure smoke discharge, while 27 patients, percutaneous silk thread suspension employed same purpose. Both groups underwent unilateral thyroidectomy central lymph node dissection via oral vestibular microincision combined...
Abstract Background: Transoral endoscopic thyroidectomy has been gaining popularity as it allows patients to avoid a visible scar in the neck. However, there are still exiting disadvantages of traditional transoral thyroidectomy，including numbness lower jaw or excessive edema. Therefore, we designed and applied novel Mini on requiring for thyroidectomy.Patients Methods: A total 55 unilateral who underwent (Mini group) were identified from August 2019 December 2019. As comparison, matched...