A5100448223- Nanoparticle-Based Drug Delivery
- RNA Interference and Gene Delivery
- Nanoplatforms for cancer theranostics
- Phagocytosis and Immune Regulation
- Immune cells in cancer
- Immunotherapy and Immune Responses
- Cancer Immunotherapy and Biomarkers
- Advanced biosensing and bioanalysis techniques
- Immune Cell Function and Interaction
- Virus-based gene therapy research
- Immune Response and Inflammation
- Liver Disease Diagnosis and Treatment
- Autophagy in Disease and Therapy
- CAR-T cell therapy research
- Effects of Radiation Exposure
- Dendrimers and Hyperbranched Polymers
- DNA Repair Mechanisms
- Graphene and Nanomaterials Applications
- Drug Transport and Resistance Mechanisms
- Liver physiology and pathology
- Cholesterol and Lipid Metabolism
- Electron Spin Resonance Studies
- MicroRNA in disease regulation
- Adenosine and Purinergic Signaling
- T-cell and B-cell Immunology
University of Pittsburgh
2016-2025
UPMC Hillman Cancer Center
2016-2025
Dartmouth College
2023-2025
Binzhou Medical University
2024-2025
Guangdong Academy of Medical Sciences
2025
Southern Medical University
2025
Guangdong Provincial People's Hospital
2025
Institute of Pharmacology
2025
Sino Biopharmaceutical (China)
2022-2024
Binzhou University
2024
We characterized the epigenetic landscape of genes encoding long noncoding RNAs (lncRNAs) across 6,475 tumors and 455 cancer cell lines. In stark contrast to CpG island hypermethylation phenotype in cancer, we observed a recurrent hypomethylation 1,006 lncRNA including EPIC1 (epigenetically-induced lncRNA1). Overexpression is associated with poor prognosis luminal B breast patients enhances tumor growth vitro vivo. Mechanistically, promotes cell-cycle progression by interacting MYC through...
Abstract Immunochemotherapy combines a chemotherapeutic agent with an immune-modulating and represents attractive approach to improve cancer therapy. However, the success of immunochemotherapy is hampered by lack strategy effectively co-deliver two therapeutics tumours. Here we report development dual-functional, immunostimulatory nanomicellar carrier that based on prodrug conjugate PEG NLG919, indoleamine 2,3-dioxygenase (IDO) inhibitor currently used for reversing tumour immune...
Certain human malignancies including prostate cancer overexpress sigma receptor, a membrane bound protein that binds haloperidol and various other neuroleptics with high affinity. An anisamide derivatized ligand possesses affinity for receptors we hypothesized its incorporation into the liposomes encapsulating doxorubicin (DOX) can specifically target deliver drug to cells receptors. A polyethylene glycol phospholipid was an ligand, which then incorporated DOX-loaded liposome. The resulting...
We have previously reported that intravenous administration of cationic lipid-protamine-DNA complexes (LPD) induces production large quantities proinflammatory cytokines are toxic and cause inhibition transgene expression. Cytokine induction appears to be mediated by the unmethylated CpG sequences since methylation plasmid DNA significantly decreases cytokine levels. In this study, inhibitory role in lipid-mediated gene transfer was further investigated using chemically well-defined,...
Doxorubicin (DOX) is one of the most commonly used antineoplastic agents, but its clinical application oftentimes coupled with severe side effects. Selective delivery DOX to tumors via nanosized drug carrier represents an attractive approach this problem. Previously, we developed a dual functional nanomicellar carrier, PEG5K-embelin2 (PEG5K-EB2), which was able deliver paclitaxel (PTX) selectively and achieve enhanced therapeutic effect. In present study, examined utility PEG5K-EB2 tumors....
Abstract The multifaceted chemo-immune resistance is the principal barrier to achieving cure in cancer patients. Identifying a target that critically involved chemo-immune-resistance represents an attractive strategy improve treatment. iRhom1 plays role cell proliferation and its expression negatively correlated with immune infiltration. Here we show decreases chemotherapy sensitivity by regulating MAPK14-HSP27 axis. In addition, inhibits cytotoxic T-cell response reducing stability of ERAP1...
The farnesoid X receptor (FXR) is a member of the nuclear superfamily that highly expressed in liver, kidney, adrenals, and intestine. FXR may play an important role pathogenesis cardiovascular diseases via regulating metabolism transport cholesterol. In this study, we report also rat pulmonary artery endothelial cells (EC), "nonclassical" bile acid target tissue. functional EC, as demonstrated by induction its genes such small heterodimer partner (SHP) after treatment with chenodeoxycholic...
To achieve synergistic therapeutic efficacy and prevent cancer relapse, chemotherapy immunotherapy have been combined as a new modality for tumor treatment. In this work, we designed redox-responsive immunostimulatory polymeric prodrug carrier, PSSN10, programmable co-delivery of an immune checkpoint inhibitor NLG919 (NLG) chemotherapeutic doxorubicin (DOX). NLG-containing PSSN10 polymers were self-assembled into nano-sized micelles that served carrier to load DOX (DOX/PSSN10 micelles)....
Pirfenidone inhibits HSC activation and liver fibrosis by targeting glutaredoxin-1 reducing Smad3 glutathionylation.