A5063867411- Peroxisome Proliferator-Activated Receptors
- Inflammatory mediators and NSAID effects
- Retinal and Macular Surgery
- Glaucoma and retinal disorders
- Eicosanoids and Hypertension Pharmacology
- Intraocular Surgery and Lenses
- Heat shock proteins research
- Mitochondrial Function and Pathology
- Electrospun Nanofibers in Biomedical Applications
- Microtubule and mitosis dynamics
- Retinal Diseases and Treatments
- Genomics and Phylogenetic Studies
- Ginseng Biological Effects and Applications
- Insect Resistance and Genetics
- Neuroscience and Neuropharmacology Research
- Insect symbiosis and bacterial influences
- Cancer-related molecular mechanisms research
- Genetics, Aging, and Longevity in Model Organisms
- Cancer, Lipids, and Metabolism
- Glycosylation and Glycoproteins Research
- Endoplasmic Reticulum Stress and Disease
- Lipid metabolism and disorders
- Fatty Acid Research and Health
- ATP Synthase and ATPases Research
- Cell death mechanisms and regulation
Chinese Academy of Medical Sciences & Peking Union Medical College
2014-2025
State Administration of Traditional Chinese Medicine of the People's Republic of China
2018-2025
Ministry of Education of the People's Republic of China
2021-2025
Huazhong University of Science and Technology
2012-2024
Hangzhou Normal University
2024
Columbia University
2020-2024
Central Hospital of Wuhan
2024
Fudan University
2023
Sun Yat-sen University
2023
National Clinical Research Center for Digestive Diseases
2023
Artemisinins, derived from the wormwood herb Artemisia annua, are most potent antimalarial drugs currently available. Despite extensive research, exact mode of action artemisinins has not been established. Here we use yeast, Saccharamyces cerevisiae, to probe core working mechanism this class agents. We demonstrate that artemisinin's inhibitory effect is mediated by disrupting normal function mitochondria through depolarizing their membrane potential. Moreover, in a genetic study, identify...
The goal of data center networking is to interconnect a large number server machines with low equipment cost, high and balanced network capacity, robustness link/server faults. It well understood that, the current practice where servers are connected by tree hierarchy switches cannot meet these requirements (Fares et al., 2008 Guo 2008). In this paper, we explore new server-interconnection structure. We observe that commodity used in today's centers usually come two built-in Ethernet ports,...
Agents targeting the PI3K/mTOR signaling axis have shown promise in early-phase clinical trials and are currently being studied later stages of development multiple indications. Experience with other targeted agents suggests that responses may be short-lived because acquired resistance to therapy. Here, we report preclinical modeling a HER2-positive, PIK3CA mutant breast cancer cell line, KPL-4. We identified heretofore-unreported mechanism resistance, specifically high-level amplification...
CE-MC server (http://cemc.sdsc.edu) provides a web-based facility for the alignment of multiple protein structures based on C-alpha coordinate distances, using combinatorial extension (CE) and Monte Carlo (MC) optimization methods. Alignments are possible user-selected PDB (Protein Data Bank) chains as well user-uploaded or combination two. The whole process generating structure alignments involves three distinct steps, i.e. all-to-all pairwise CE algorithm, iterative global MC algorithm...
Chromatinolysis refers to enzymatic degradation of nuclear DNA and is regarded as one the crucial events leading cell death. Mixed-lineage kinase domain-like protein (MLKL) has been identified a key executor necroptosis, but it remains unclear whether MLKL contributes necroptosis via regulation chromatinolysis. In this study, we find that shikonin induces activation chromatinolysis in glioma cells vitro vivo, which are accompanied with translocation AIF γ-H2AX formation. studies reveal...
Abstract —The application of mechanical strain to cultured cardiac myocytes in vitro leads activation the brain natriuretic peptide (BNP) gene promoter, a marker hypertrophy. We have previously shown that this results from both direct mechanostimulatory event and an indirect autocrine/paracrine stimulation involving sequential production angiotensin II endothelin (ET). In present study, we examined role p38 mitogen-activated protein kinase (MAPK) extracellular signal regulated (ERK)...
Background Peripheral arterial disease (PAD) is a common accounting for about 12% of the adult population, and causes significant morbidity mortality. Therapeutic angiogenesis using angiogenic factors has been considered to be potential treatment option PAD patients. In this study, we assessed new factor AGGF1 therapeutic in critical limb ischemia model mice PAD. Methods Results We generated unilateral hindlimb by ligation right iliac artery femoral artery. Ischemic with intrasmuscular...
The efficacy of stem cell therapy is substantially compromised due to low survival rate and poor local retention post-delivery. These issues drastically limit the application cells for ischemic limb therapy, which requires effective blood perfusion skeletal muscle regeneration. Herein, based on microfluidic technology, an integrated cytokine co-delivery system designed functional salvage was constructed by first incorporating myogenic cytokine, fibroblast growth factor 19 (FGF19), into...
Salvianolic acid B (SalB) and ginsenoside Re (Re) protect endotheliocytes against apoptosis through different mechanisms. However, whether both compounds could synergistically endothelial cells oxidized low-density lipoprotein (Ox-LDL)-induced is unclear. This study aimed to assess the protective effect of combined SalB (SR) treatment on Ox-LDL-induced explore mechanism underlying this effect. Results showed that SalB, Re, or SR apoptosis. Furthermore, composition was optimized central...
Purpose: This study aimed to the inhibitory effect of niraparib alone or in combination with GD2 specific antibody on Bladder Cancer (BCa). Methods: The migration ability BCa cells was assessed through a scratch assay. CCK-8 assay performed evaluate viability cells, and Transwell invasion assays were utilized examine invasive capacity. expression levels E-cadherin vimentin measured using QRT-PCR. Results: Western blot showed EMT level be lowest niraparib+GD2 group. transwell suggested that...
We describe a simple and efficient technique that allows scarless engineering of Drosophila genomic sequences near any landing site containing an inverted attP cassette, such as MiMIC insertion. This two-step method combines phiC31 integrase-mediated site-specific integration homing nuclease-mediated resolution local duplications, efficiently converting the original allele to modified alleles only have desired change(s). Dominant markers incorporated into this allow correct individual flies...
Internal sensory neurons monitor the chemical and physical state of body, providing critical information to central nervous system for maintaining homeostasis survival. A population larval
Achieving “dual carbon” targets by containing carbon emissions while sustaining economic growth is challenging. This study examines the varying dependency levels among China’s 30 provincial-level administrative units, considering spatial correlations in emissions. Using a semi-parametric coefficient autoregressive panel model on 2004–2019 data, this shows following: (i) The relationship between and forms an “S”-shaped curve, with contribution decreasing as tertiary industry grows, defining...
Purpose: The aim of the study was to characterize underlying mutation in a large multiplex Chinese family with hereditary nuclear cataract.Methods: A 6-generation having cataract recruited and clinically verified. Blood DNA samples were obtained from 53 available members. Linkage analyses performed on known candidate regions for 36 polymorphic microsatellite markers. To identify mutations related cataract, direct sequencing approach applied gene residing our linkage locus.Results: locus...
The activation of hepatic stellate cells (HSCs) plays a key role in the occurrence liver fibrosis,and promoting apoptosis activated HSCs or reducing number can reverse development fibrosis. In our previous studies, we have demonstrated that CCAAT/enhancer binding protein α (C/EBP-α) played an important HSCs, thereby exerting anti-liver fibrosis effect. Unlike apoptosis, autophagy, as caspase-independent programmed cell death, promptly remove abnormal accumulation substances damaged...
Apoptosis is a regulated cellular suicide program that critical for the development and maintenance of healthy tissues. Previous studies have shown small kinetochore associated protein (SKAP) cooperates with mitotic spindle proteins to regulate mitosis. However, role SKAP in apoptosis has not been investigated. We identified new interaction involving SKAP, we propose mechanism through which regulates cell apoptosis. Our experiments demonstrate both overexpression knockdown sensitize cells...
Notoginsenoside R1 (NGR1) is separate from Panax notoginsenosides (PNS), and plays a role similar to phytoestrogen in preventing treating cardiovascular diseases. However, the protective mechanism of NGR1 myocardial ischemia/reperfusion injury via estrogen receptor (ER) pathway remains unclear, which hinder its application. This study aimed preventive mechanisms apoptosis H9c2 cardiomyocytes after hypoxia/reoxygenation (H/R). did not affect expression ERα ERβ proteins normal cardiomyocytes....