A5100607609- Crystallization and Solubility Studies
- X-ray Diffraction in Crystallography
- MicroRNA in disease regulation
- Extracellular vesicles in disease
- Immune cells in cancer
- Nanoplatforms for cancer theranostics
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- RNA Interference and Gene Delivery
- Immune Response and Inflammation
- Nanoparticle-Based Drug Delivery
- Advanced Nanomaterials in Catalysis
- Metal complexes synthesis and properties
- Advancements in PLL and VCO Technologies
- Radio Frequency Integrated Circuit Design
- Mesenchymal stem cell research
- Advanced biosensing and bioanalysis techniques
- S100 Proteins and Annexins
- Epigenetics and DNA Methylation
- Anesthesia and Neurotoxicity Research
- Chemical Synthesis and Analysis
- Adipose Tissue and Metabolism
- Analog and Mixed-Signal Circuit Design
- Metalloenzymes and iron-sulfur proteins
- Cancer Immunotherapy and Biomarkers
- Cancer, Hypoxia, and Metabolism
Capital Medical University
2011-2025
Shanghai Jiao Tong University
2024
Tianjin Medical University Cancer Institute and Hospital
2024
National Clinical Research
2024
State Key Laboratory of Respiratory Disease
2024
Guangzhou Medical University
2024
First Affiliated Hospital Zhejiang University
2024
Zhejiang Center for Disease Control and Prevention
2024
Shanghai Clinical Research Center
2024
Renji Hospital
2024
Background: Among the many immunosuppressive cells in tumor microenvironment, tumor-associated-macrophages (TAMs) are well known to contribute development. TAMs can be conditioned (polarized) transition between classical M1-like macrophages, or alternatively M2-like macrophages. Both regulated by signaling molecules microenvironment. secrete classic inflammatory cytokines that kill tumors promoting cell necrosis and immune infiltration into In contrast, exhibit powerful tumor-promoting...
Following transient forebrain ischemia, astrocytes play a key role in determining whether or not neurons the hippocampal CA1 sector go on to die delayed fashion. MicroRNAs (miRNAs) are novel class of RNAs that control gene expression at post‐transcriptional level and miR‐29 family is highly expressed astrocytes. In this study we assessed levels hippocampus following ischemia found after short periods reperfusion, miR‐29a significantly increased resistant dentate gyrus, but decreased...
Mesenchymal stem cells show remarkable versatility and respond to extracellular micro environmental cues by altering their phenotype behavior. In this regard, the MSC’s immunomodulatory properties in tissue repair are well documented. The paracrine effects of MSCs immunomodulation are, part, attributable secreted vesicles (EVs). When migrate wound bed, they exposed a myriad inflammatory signals. To understand response an environment from EV perspective, we sought evaluate cytokine TNFα on...
As an unconventional subpopulation of T lymphocytes, γδ cells can recognize antigens independently major histocompatibility complex restrictions. Recent studies have indicated that play contrasting roles in tumor microenvironments-promoting progression some cancers (eg, gallbladder and leukemia) while suppressing it others lung gastric). are mainly enriched peripheral mucosal tissues. the cervix is a mucosa-rich tissue, role cervical cancer warrants further investigation.
Several DNA-damaging antitumor agents, including ruthenium complexes, induce immunogenic cell death (ICD). In this study, an arginyl-glycyl-aspartic acid (RGD) peptide-modified carboline complex (KS-Ru) is synthesized as a chemotherapeutic nanodrug and ICD inducer. The RGD peptide, integrin ligand, provides tumor-specific targeting promotes self-assembly of the KS-Ru complex. pH-responsive assessed through transmission scanning electron microscopy. Additionally, in vitro cytotoxic activity...
Abstract Sonodynamic therapy (SDT) is demonstrated to trigger the systemic immune response of organism and facilitate treatment metastatic tumors. However, SDT‐mediated neutrophil extracellular traps (NETs) formation can promote tumor cell spread, thus weakening therapeutic effectiveness Herein, amorphous CoW‐layered double hydroxide (a‐CoW‐LDH) nanosheets are functionalized with a peptidyl arginine deiminase 4 (PAD4) inhibitor, i.e., YW3‐56, construct multifunctional nanoagent (a‐LDH@356)...
Although phototherapy has been considered as an emerging and promising technology for cancer therapy, its therapeutic specificity efficacy are severely limited by nonspecific uptake normal tissues, tumor hypoxia, so on. Herein, combination-responsive strategy (CRS) is applied to develop one kind of hyaluronic acid-hybridized Ru nanoaggregates (HA-Ru NAs) enhanced via the reasonable integration receptor-mediated targeting (RMT) tumor-microenvironment responsiveness (TMR). In this nanosystem,...
MicroRNAs (MiRNAs) play important regulatory roles in many cellular processes. MiR-143 is highly enriched the mouse ovary, but its and underlying mechanisms are not well understood. In current study, we show that miR-143 located granulosa cells of primary, secondary antral follicles. To explore specific functions miR-143, transfected inhibitor into primary cultured to study loss function results showed silencing significantly increased estradiol production steroidogenesis-related gene...
Abstract The colon is the largest compartment of immune system, with innate cells exposed to antigens in environment. However, mechanisms by which system instigated are poorly defined colorectal cancer (CRC). Here, a population CD16 + neutrophils that specifically accumulate CRC tumor tissues imaging mass cytometry (IMC), fluorescence, and flow cytometry, demonstrated pro‐tumor activity disturbing natural killer (NK) identified. It found these possess abnormal cholesterol accumulation due...
Triple-negative breast cancer is a highly aggressive and heterogeneous subtype characterized by early metastasis, poor prognosis, high recurrence. Targeting histone citrullination-mediated chromatin dysregulation to induce epigenetic alterations shows great promise in TNBC therapy. We report the synthesis, optimization, evaluation of novel series β-carboline-derived peptidyl arginine deiminase 4 inhibitors that exhibited potent inhibition cell proliferation. The most outstanding PAD4...
Abstract Background Embryonic stem cell-derived extracellular vesicles (ESC-EVs) possess therapeutic potential for a variety of diseases and are considered as an alternative ES cells. Acute kidney injury (AKI) is common acute severe disease in clinical practice, which seriously threatens human life health. However, the roles mechanisms ESC-EVs on AKI remain unclear. Methods In this study, we evaluated effects physiological repair pathological using murine ischemia-reperfusion injury-induced...
ADVERTISEMENT RETURN TO ISSUEPREVCommunicationNEXTConstruction and DNA Condensation of Cyclodextrin-Based Polypseudorotaxanes with Anthryl GraftsYu Liu, Lu Yu, Yong Chen, Yan-Li Zhao, Hua YangView Author Information Department Chemistry, State Key Laboratory Elemento-Organic Nankai University, Tianjin 300071, P. R. China Cite this: J. Am. Chem. Soc. 2007, 129, 35, 10656–10657Publication Date (Web):August 11, 2007Publication History Received29 May 2007Published online11 August inissue 1...
Mesenchymal stem cell derived extracellular vesicles (MSC EVs) possess excellent immunomodulatory and therapeutic properties. While beneficial, from a translational perspective, with consistent functionality target specificity are required to achieve the goals of precision medicine tissue engineering. Prior research has identified that miRNA composition mesenchymal contributes significantly towards functionality. In this study, we hypothesized vesicle can be rendered pathway-specific using...
Introduction: Lung cancer is a major health concern worldwide owing to its high incidence and mortality rates. Therefore, identification of new therapeutic targets strategies for lung critical improving patient outcomes. Peptidyl arginine deiminase 4 (PAD4) promotes tumor growth metastasis by catalyzing the citrullination histones, making it potential target. Although PAD4 inhibitors have shown in treatment variety tumors, existing lack sufficient specificity cause substantial systemic...