A5101467324- Glioma Diagnosis and Treatment
- Intracranial Aneurysms: Treatment and Complications
- Vascular Malformations Diagnosis and Treatment
- Cancer-related molecular mechanisms research
- Traumatic Brain Injury and Neurovascular Disturbances
- Moyamoya disease diagnosis and treatment
- Cerebrospinal fluid and hydrocephalus
- Intracerebral and Subarachnoid Hemorrhage Research
- Circular RNAs in diseases
- Ferroptosis and cancer prognosis
- RNA modifications and cancer
- Meningioma and schwannoma management
- Neuroinflammation and Neurodegeneration Mechanisms
- Epilepsy research and treatment
- Immune cells in cancer
- Neurosurgical Procedures and Complications
- Brain Metastases and Treatment
- Spinal Fractures and Fixation Techniques
- Neurological Complications and Syndromes
- MicroRNA in disease regulation
- Cerebrovascular and Carotid Artery Diseases
- Microtubule and mitosis dynamics
- RNA Research and Splicing
- Epigenetics and DNA Methylation
- Fetal and Pediatric Neurological Disorders
Soochow University
2016-2025
Second Affiliated Hospital of Soochow University
2016-2025
Beijing Tian Tan Hospital
2011-2025
Capital Medical University
2015-2025
National Clinical Research Center for Digestive Diseases
2016-2025
Beijing Institute of Neurosurgery
2024
Beijing Tongren Hospital
2021-2023
Chinese Institute for Brain Research
2016-2020
Merck Canada Inc. (Canada)
2011
Vancouver Biotech (Canada)
2011
The Glioblastoma (GBM) immune microenvironment plays a critical role in tumor development, progression, and prognosis. A comprehensive understanding of the intricate milieu its interactions remains unclear, single-cell analysis is crucially needed. Leveraging mass cytometry (CyTOF), we analyzed immunocytes from 13 initial three recurrent GBM samples their matched peripheral blood mononuclear cells (pPBMCs). Using panel 30 markers, provide high-dimensional view complex microenvironment....
Gliomas are the most common and deadly type of primary brain tumor. In this study, we showed that cAMP response element-binding protein (CREB), a proto-oncogenic transcription factor is overexpressed in gliomas, can promote gliomagenesis by modulating expression oncogenic microRNA-23a (mir-23a). First, found CREB highly expressed glioma tissues cell lines. also essential for growth survival vitro critical vivo. Second, microRNA microarray, ChIP-chip, ChIP-quantitative PCR, luciferase...
Brain glioma is the most common primary intracranial tumor characterized by dismal prognosis and frequent recurrence, yet a real-time reliable biological approach to monitor response progression still lacking. Recently, few studies have reported that circulating cells (CTCs) could be detected in glioblastoma multiform (GBM), providing possibility of its application brain monitoring system. But limits exist, because detection rate CTCs low was exclusively limited high- grade gliomas. Here, we...
Migration-proliferation dichotomy is a common mechanism in gliomagenesis; however, an understanding of the exact molecular this "go or grow" phenomenon remains largely incomplete. In present study, we first found that microRNA-9 (miR-9) highly expressed glioma cells. MiR-9 inhibited proliferation and promoted migration cells by directly targeting cyclic AMP response element-binding protein (CREB) neurofibromin 1 (NF1), respectively. Our data also suggested migration-inhibitory role for CREB...
// Wen Wang 1, 2, 3, 7 , Fan Yang Lu Zhang 5 Jing Chen 4, Zheng Zhao Haoyuan 6, Wu Tingyu Liang Xiaoyan Yan Jiye Li 4 Qing Lan 2 Jiangfei Jizong 8 1 Department of Neurosurgery, Beijing Tiantan Hospital, Capital Medical University, Beijing, China The Second Affiliated Hospital Soochow Suzhou, 3 Molecular Neuropathology, Neurosurgical Institute, Ophthalmology, School Medicine, Shandong Jinan, 6 Zhujiang Southern Guangzhou, Chinese Glioma Cooperative Group (CGCG), National Clinical Research...
Glioblastoma is the most malignant tumor and has high mortality rate. The methylated prompter of MGMT results in chemotherapy sensitivity for these patients. However, there are still other factors that affected prognosis glioblastoma patients with similar methylation status. We developed a signature three genes screened from whole genome mRNA expression profile Chinese Glioma Genome Atlas (CGGA) RNAseq data Cancer (TCGA). Patients low risk group had longer survival than those (median overall...
Background To develop an artificial intelligence system that can accurately identify acute non-traumatic intracranial hemorrhage (ICH) etiology (aneurysms, hypertensive hemorrhage, arteriovenous malformation (AVM), Moyamoya disease (MMD), cavernous (CM), or other causes) based on non-contrast computed tomography (NCCT) scans and investigate whether clinicians benefit from it in a diagnostic setting. Methods The deep learning model was developed with 1,868 eligible NCCT ICH collected between...
This study aimed to investigate the brain's hemodynamic responses (HRO) and functional connectivity in patients with disorders of consciousness (DoC) response acute pressure pain stimulation using near-infrared spectroscopy (NIRS). Patients diagnosed DoC underwent while brain activity was measured NIRS. Changes oxygenated hemoglobin (HbO) deoxygenated (HbR) concentrations were monitored across several regions interest (ROIs), including primary somatosensory cortex (PSC), motor (PMC),...
Summary Aims To investigate the role of LINC00152 in high‐grade glioma (HGG). Methods We collected data from Chinese Glioma Genome Atlas (CGGA) microarray, CGGA RNA sequencing, and GSE16011 datasets to evaluate expression prognostic relationship patients with HGGs. A knockdown assay was performed determine function development progression vitro vivo. Results The increased grade, especially mesenchymal TCGA subtype. independently associated poor prognosis, overall survival (OS) high group...
// Wen Wang 1,2,4,5,* , Hao Li 1,4,5,* Lanbing Yu 1,4,5 Zheng Zhao 3 Haoyuan 6 Dong Zhang Yan Qing Lan 2 Jiangfei and Jizong 1,2,4,5 1 Department of Neurosurgery, Beijing Tiantan Hospital, Capital Medical University, Beijing, China The Second Affiliated Hospital Soochow Suzhou, Neurosurgical Institute, 4 National Clinical Research Center for Neurological Diseases, 5 Key Laboratory Translational Medicine Cerebrovascular Zhujiang Southern Guangzhou, * These authors have contributed equally to...
The tumor immune microenvironment (TIME) plays a pivotal role in development, progression, and prognosis. However, the characteristics of TIME diffuse astrocytoma (DA) are still unclear. Leveraging mass cytometry with panel 33 markers, we analyzed infiltrating cells from 10 DA 4 oligodendroglioma (OG) tissues provided single cell-resolution landscape intricate microenvironment. Our study profiled composition confirmed presence cells, such as glioma-associated microglia/macrophages (GAMs),...
Objective: To explore the prognostic significance of metabolic parameters in postoperative peritumoral edema zone (PEZ) patients with glioblastoma (GBM) based on proton magnetic resonance spectroscopy (MRS). Methods: The MRS data 67 GBM from Beijing Tiantan Hospital were retrospectively reviewed. Metabolite ratios including Cho/NAA, Cho/Cr, and NAA/Cr both PEZ contralateral normal brain region recorded. Log-rank analysis Cox regression model used to identify correlated progression-free...
OBJECTIVE The pathogenesis of cerebral aneurysms (CAs) remains largely unknown. Long noncoding RNAs (lncRNAs) were reported recently to play crucial roles in many physiological and biological processes. Here, the authors compared gene-expression profiles CAs their control arteries investigate potential functions lncRNAs formation CAs. METHODS A prospective case-control study was designed identify changes expression mRNAs between 12 saccular CA samples (case group) paired superficial temporal...
Background. There is evidence suggesting that genetic variants in the chondroitin sulfate proteoglycan2 (CSPG2, also known as versican) gene are involved pathogenesis of intracranial aneurysms (IAs). Some authors have demonstrated single nucleotide polymorphisms (SNPs) rs173686 and rs251124 promoter region CSPG2 associated with IAs. We performed a case-control study to investigate whether these SNPs might affect development IAs Chinese Han nationality. Methods. The group comprised 240...
Abstract Due to the extremely intrinsic heterogeneity among glioma patients, outcomes of these patients are tremendously different. Therefore, exploitation novel biomarker classification is vitally important for deep insight into essence and predicting prognosis glioma. We aim analyze correlation between TP73 mRNA expression, DNA methylated alteration WHO grade II/III glioma, utilizing bioinformatics evaluate its significance as a risk‐factor in patients. The analysis found that expression...