A5100676115- EEG and Brain-Computer Interfaces
- Circadian rhythm and melatonin
- Neuroscience and Neural Engineering
- Epigenetics and DNA Methylation
- Retinoids in leukemia and cellular processes
- Neurogenesis and neuroplasticity mechanisms
- Adipose Tissue and Metabolism
- Congenital heart defects research
- Retinal Development and Disorders
- Advanced Memory and Neural Computing
- Genetics, Aging, and Longevity in Model Organisms
Dalian Medical University
2020
First Affiliated Hospital of Dalian Medical University
2020
Shanxi Medical University
2019
Shanghai Institutes for Biological Sciences
2015-2016
Chinese Academy of Sciences
2015-2016
Abstract Although food availability is a potent synchronizer of the peripheral circadian clock in mammals, underlying mechanisms are unclear. Here, we show that hepatic Bmal1, core transcription activator molecular clock, post-transcriptionally regulated by signals from insulin, an important hormone temporally controlled feeding. Insulin promotes postprandial Akt-mediated Ser42-phosphorylation Bmal1 to induce its dissociation DNA, interaction with 14-3-3 protein and subsequently nuclear...
The incidence of spinal cord injury (SCI) continues to increase; however, the involved mechanisms remain unclear. Anaphase promoting complex (APC) and its regulatory subunit Cdh1 play important roles in growth, development, repair central nervous system (CNS). is pathophysiological processes neuronal apoptosis astrocyte-reactive proliferation after ischemic brain injury, whereas role played by APC-Cdh1 activation oligodendrocyte precursor cells (OPCs) SCI remains unresolved. Using primary...
Electrical stimulations have demonstrated positive effects in improving the survival rates of retinal cells and restoring visual acuity patients with ophthalmic diseases. However, optimal application parameters electrical still need further exploration for better clinical efficacy. In this paper, a simulation study was performed eyes stimulation stimulating electrode placed at six different positions on eyelids. The results showed that induced electric field mainly distributed around front...
At present, a large number of confirmatory studies have shown that electrical stimulation has been an important method for the treatment ophthalmic diseases, but how to optimize is still problem be solved. In this paper, effects electrode size and position on current maximum in different tissues head were studied by model simulation with SimNIBS software. The results showed 1) both smaller stimulating monocular bipolar transpalpebral can effectively reduce impact gray matter other brain; 2)...