A5100402089- Oral and Maxillofacial Pathology
- Immunotherapy and Immune Responses
- Immune Cell Function and Interaction
- Phagocytosis and Immune Regulation
- RNA Interference and Gene Delivery
- Bone Tumor Diagnosis and Treatments
- Immune Response and Inflammation
- Nanomaterials for catalytic reactions
- Cancer Immunotherapy and Biomarkers
- Immune cells in cancer
- Craniofacial Disorders and Treatments
- RNA modifications and cancer
- Electrocatalysts for Energy Conversion
- Covalent Organic Framework Applications
- Cleft Lip and Palate Research
- Hydrogels: synthesis, properties, applications
- Cancer Cells and Metastasis
- Advanced Drug Delivery Systems
- Nasal Surgery and Airway Studies
- Cancer Mechanisms and Therapy
- Autophagy in Disease and Therapy
- Extracellular vesicles in disease
- Head and Neck Surgical Oncology
- Adenosine and Purinergic Signaling
- Membrane Separation Technologies
Sichuan University
2014-2025
Cornell University
2022-2025
Shanghai Laser Technology Institute
2024
State Key Laboratory of Hydraulics and Mountain River Engineering
2022-2023
West China Second University Hospital of Sichuan University
2022-2023
State Key Laboratory of Oral Diseases
2012-2023
Hunan University of Traditional Chinese Medicine
2022
Fourth People's Hospital of Sichuan Province
2022
Nanjing University of Chinese Medicine
2022
Guangxi Center for Disease Prevention and Control
2022
Secondary lymphoid organs (SLOs) are an important target for mRNA delivery in various applications. While the current method relies on drainage of nanoparticles to lymph nodes by intramuscular (IM) or subcutaneous (SC) injections, efficient carrier SLOs-targeting systemic administration (IV) is highly desirable but yet be available. In this study, we developed using phosphatidylserine (PS), a well-known signaling molecule that promotes endocytic activity phagocytes and cellular entry...
A bimetallic catalytic membrane microreactor (CMMR) with nanoparticles in pores has been fabricated via flowing synthesis. The nanoparticle is successfully immobilized along its thickness direction. Enhanced synergistic catalysis can be expected this CMMR. As a concept-of-proof, Cu–Ag core–shell have and for p-nitrophenol (p-NP) hydrogenation. Transmission electron microscopy (TEM) the characterization of nanostructure X-ray photoelectron spectroscopy (XPS) transfer behavior between bimetal...
Abstract Background Stimulator of IFN genes (STING) is highly expressed in the livers non-alcoholic fatty liver disease (NAFLD) patients and high fat diet (HFD) induced NAFLD mice model. The STING signaling-mediated inflammation has been shown to play a critical role metabolic disorders. Lingguizhugan decoction (LGZG), Traditional Chinese herbal decoction, applied treat disorders for many years. However, whether LGZG can alleviate progression through inhibiting remains unclear. This study...
Abstract Background. Matrix metalloproteinases (MMPs) and transforming growth factor‐β1 (TGF‐β1) are important in many physiological pathological processes. Methods. Immunohistochemistry for MMP‐2, MMP‐9, membrane‐type 1 MMP (MT1‐MMP, MMP‐14), tissue inhibitor of matrix metalloproteinase (TIMP)‐2, TGF‐β were performed on normal mucosa, nonatrophic oral lichen planus, atrophic squamous cell carcinomas (OSCC) resulting from planus. Results. Expression MMPs progressively increased mucosa to...
Pharmacotherapy towards hypercalcemia treatment mainly caused by osteoporosis and bone tumor is an effective method to regulate in vivo calcium equilibrium. As a clinical therapeutic peptide, salmon calcitonin (sCT) considered as quick-acting medicine but it limited the short half-life. To address this challenge, we designed injectable thermo-sensitive hydrogel based on hydroxypropyl chitin (HPCH) incorporated complex of sCT hyaluronic acid (HA) (sCT-HA) with high association efficiency up...
Huo Luo Xiao Ling Dan (HLXLD), a famous Traditional Chinese Medicine (TCM) classical formula, possesses anti-atherosclerosis (AS) activity. However, the underlying molecular mechanisms remain obscure.The network pharmacology approach, docking strategy, and in vitro validation experiment were performed to explore potential active compounds, key targets, main signaling pathways, of HLXLD treating AS.Several public databases used search for components targets HLXLD, as well AS-related targets....
Abstract Sarcopenia recognition is very crucial in the early diagnosis of sarcopenia. However, commonly used screening methods are limited by real‐time property, portability, and convenient usability at home. Herein, an electrospun BaTiO 3 film proposed a piezoelectric sensor with silver electrodes polyimide substrates fabricated. The exhibits high piezoelectricity (74.2 pC N −1 ), sensitivity, linearity, low detection limit (0.2 mN), significant bending ability (bending angle can exceed...
Abstract Growing evidence shows that granulocyte macrophage colony-stimulating factor (GM-CSF) has progression-promoting potentials in certain solid tumors, which is largely attributed to the immunomodulatory function of this cytokine tumor niches. However, little known about effect GM-CSF on cancer cells. Herein, we show chronic exposure colon cells GM-CSF, harbor its receptor, leads occurrence epithelial mesenchymal transition (EMT), time and dose-dependent manners. These GM-CSF-educated...
A catalytic membrane nanoreactor (CMNR) with Cu-Agx (where x is the millimolar concentration of AgNO3) bimetallic catalysts immobilized in pores has been fabricated via coupling flowing synthesis and replacement reaction. Surface characterization by transmission electron microscopy (TEM) gives obvious evidence formation Cu-Ag core-shell nanostructures Ag islands deposited on Cu core metal. An apparent high shift phenomenon for element a low was determined X-ray photoelectron spectroscopy...
The mononuclear phagocytic system is recognized as a major scavenger of mRNA-lipid nanoparticles (LNPs), clearing and redirecting these particles away from their intended targets thus diminishing delivery efficacy. Understanding the mechanism by which mRNA-LNPs interact with phagocytes how this interaction affects mRNA transfection critical to enhancing mRNA. In study, we temporarily depleted both circulating resident macrophages (MF) evaluated efficiency biodistribution mRNA-LNPs. We first...
Abstract The ultrafast‐laser‐matter interactions enable “top‐down” laser surface structuring, especially for materials difficult to process, with “bottom‐up” self‐organizing features. subwavelength scenarios of laser‐induced structuring are improved in defects and long‐range order by applying positive/negative feedbacks. It is still hardly reported supra‐wavelength more associated complicated thermo/hydro‐dynamics. For the first time knowledge, near‐field‐regulated ultrafast‐laser...