A5100693492- Immune cells in cancer
- Phagocytosis and Immune Regulation
- Immune Cell Function and Interaction
- Hepatocellular Carcinoma Treatment and Prognosis
- Cutaneous Melanoma Detection and Management
- Hepatitis B Virus Studies
- Chemokine receptors and signaling
- Galectins and Cancer Biology
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Liver Disease Diagnosis and Treatment
- Wheat and Barley Genetics and Pathology
- Autophagy in Disease and Therapy
- Cancer Immunotherapy and Biomarkers
- Nonmelanoma Skin Cancer Studies
- Extracellular vesicles in disease
- Psoriasis: Treatment and Pathogenesis
- Contact Dermatitis and Allergies
- Agronomic Practices and Intercropping Systems
- Cancer and Skin Lesions
- Cancer Diagnosis and Treatment
- Genetic and rare skin diseases.
- Dermatologic Treatments and Research
- Cutaneous lymphoproliferative disorders research
- Plant Ecology and Soil Science
- Multiple and Secondary Primary Cancers
Gansu Agricultural University
2024-2025
Sun Yat-sen University Cancer Center
2016-2024
Anhui Normal University
2022-2024
Wenzhou Medical University
2024
Sun Yat-sen University
2016-2024
Peking Union Medical College Hospital
2020-2024
Chinese Academy of Medical Sciences & Peking Union Medical College
2020-2024
Lanzhou University
2023-2024
Lanzhou University Second Hospital
2023-2024
The Fourth People's Hospital of Ningxia Hui Autonomous Region
2024
Background: Numerous studies have attempted to apply artificial intelligence (AI) in the dermatological field, mainly on classification and segmentation of various dermatoses. However, researches under real clinical settings are scarce. Objectives: This study was aimed construct a novel framework based deep learning trained by dataset that represented environment tertiary class hospital China, for better adaptation AI application practice among Asian patients. Methods: Our composed 13,603...
The existence, regulation, and functions of IL21+ immune cells are poorly defined in human cancers. Here, we identified a subset protumorigenic TFH-like hepatocellular carcinoma. These were the major source IL21 tumors represented about 10% CD4+ T-cell population at levels comparable with TFH present lymph nodes. However, these displayed unique CXCR5-PD-1lo/-BTLA-CD69hi tissue-resident phenotype substantial IFNγ production, which differed from cells. Toll-like receptor 4 (TLR4)-elicited...
Macroautophagy/autophagy is an important catabolic process mediating cellular homeostasis and plays critical roles in cancer development. Whereas autophagy has been widely studied various pathological models, little known about the distribution, clinical significance regulatory mechanism of this human hepatocellular carcinoma (HCC). In present study, we found that tumor tissues exhibited significantly increased levels compared with non-tumor tissues, cells higher were predominantly enriched...
Inflammation is a component of tumor progression mechanisms. Neutrophils are common inflammatory infiltrate in many tumors, but their regulation and functions neoplasia not understood. Here, we showed, detailed studies c-Met molecule 225 untreated patients with hepatocellular carcinoma (HCC), that high infiltration neutrophils HCC tissues determined malignant cell c-Met-associated clinical outcome patients. High HCCs were enriched predominantly invading edge HCCs; the accumulated major...
Alternatively activated macrophages in tumor microenvironment is defined as M2 tumor-associated (M2 TAMs) that promote cancer progression. However, communicative mechanisms between TAMs and cells squamous cell carcinoma of head neck (SCCHN) remain largely unknown. Quantitative real-time PCR, western blotting, enzyme-linked immunosorbent assay flow cytometry were applied to quantify mRNA protein expression genes related TAMs, epithelial–mesenchymal transition (EMT) stemness. Wounding-healing...
Planting halophytes is a widely used method of phytoremediation for saline soils. The succulent Halogeton glomeratus and Suaeda glauca are remediation soil in the arid region Northwestern China. However, whether intercropping H. S. can increase improvement effect yet to be proved. Therefore, this study analyzed three planting modes: monocropping (Hg), (Sg), (Hg||Sg). These were applied field experiments, with biomass physicochemical properties measured each treatment, mechanism was using...
Introduction Inorganic phosphorus (Pi) is an indispensable nutrient for plant growth, with phosphate transporter proteins (PHTs) having key roles in Pi uptake, transport, and signal transduction plants. However, a systematic comprehensive genomic analysis of the wheat PHT family (covering PHT1-5 PHO1 ) lacking. Methods In view this, we successfully identified 180 Triticum aestivum ( TaPHT members 6 families using bioinformatics, performed in-depth phylogenetic analyses between these protein...
Background and Objective: Patients with psoriasis have a significantly elevated risk of periodontitis compared the nonpsoriasis controls. However, data regarding difference in periodontal health status patients controls are limited inconsistent; hence, specialized meta-analysis that quantitatively between subjects by evaluating related clinical indexes was needed. The aim this to evaluate whether is worse than subjects. Methods: We searched PubMed EMBASE for all eligible studies were...
Basal cell carcinoma (BCC) is the most common cutaneous malignancy. Occasionally, it may have an appearance similar to that of some benign pigmented skin lesions. Therefore, additional information needed differentiate these lesions.A diagnostic accuracy study was performed from February 2018 April 2019. All lesions underwent ultrasound examination with 50 and 20 MHz probes. The high-frequency (HFUS) images were evaluated independently by 2 experienced doctors for presence predefined...
For patients with hepatitis B virus (HBV)-related hepatocellular carcinoma (HCC) treated curative radiofrequency ablation (RFA), the effect of entecavir (ETV) vs. tenofovir disoproxil fumarate (TDF) on recurrence-free survival (RFS) and overall (OS) remains unclear. We aimed to compare outcomes receiving ETV or TDF after RFA. This study consecutively collected who were (n = 202) 102) for chronic (CHB) RFA HCC from December 2015 January 2021 at Sun Yat-sen University Cancer Center. There 130...
Osteoarthritis (OA) is a common chronic disease characterized by progressive cartilage degeneration and secondary synovial inflammation. Bergamottin (Ber) an important natural derivative of the furanocoumarin compound, extracted from foods, such as pulp grapefruits pomelos. Ber exhibits several characteristicsthat are beneficial to human health, anti-inflammation, antioxidant, anti-cancer effects. However, role in treatment OA has not been elucidated date. Therefore, present study, vitro...
Background: Liver cancer is one of the most common malignant tumors, and worldwide, its incidence ranks sixth, morality third. Post-hepatectomy liver failure (PHLF) leading cause death in patients who have undergone resection. This retrospective study investigated risk factors for PHLF by predicting constructing an index to evaluate risk. was achieved combining lab tests with indocyanine green (ICG) clearance test. Methods: The analyzed 1081 hepatocellular carcinoma (HCC) had received...
Both tolerogenicity and immunogenicity of dendritic cells (DCs) are regulated by their intracellular metabolism. As a rate‑limiting enzyme tryptophan (Trp) metabolism, indoleamine 2,3‑dioxygenase (IDO) is involved in regulating the functions numerous cell types, including DCs, subset which has high capacity for producing IDO to control over‑activated inflammation. To identify mechanisms stable DC lines with both gain‑ reduction‑of‑function were established using recombinant DNA technique....
Prepubertal girls are one of the vulnerable populations vulvar lichen sclerosus (VLS), which results in a decreased quality life and increases risk cancer. But therapeutic effects traditional topical remedies unsatisfactory some pediatric patients. 5-Aminolevulinic acid photodynamic therapy (ALA-PDT) is an effective treatment for refractory VLS patients, but no study has been conducted child The patients included this underwent three sessions ALA-PDT at 2-week intervals. All were evaluated...
Abstract Halophyte Halogeton glomeratus mostly grows in saline desert areas arid and semi‐arid regions is able to adapt adverse conditions such as salinity drought. Earlier transcriptomic studies revealed activation of the HgS2 gene leaf H. seedlings when exposed conditions. To identify properties , we used yeast transformation overexpression Arabidopsis . Yeast cells genetically transformed with exhibited K + uptake Na efflux compared control (empty vector). Stable improved its resistance...
Background Transarterial therapy (TAT), bevacizumab (Bev), and immune checkpoint inhibitors (ICIs) have individually exhibited efficacy in treating advanced-stage hepatocellular carcinoma (HCC). This study aimed to assess the safety of combination these three treatments as a neoadjuvant modality patients with locally advanced HCC. Methods The primary endpoint is overall survival (OS). second progression free (PFS), objective response rate (ORR), pathological safety. Results A total 54...
A high hepatitis B virus (HBV) load is a common exclusion criterion in hepatocellular carcinoma (HCC) clinical trials for anti-programmed cell death (PD)-1 immunotherapy. However, the validity of this barely verified. This study aimed to evaluate impact baseline HBV DNA levels and antiviral therapy on oncological outcomes liver functions patients with HCC receiving anti-PD-1 immunotherapy.We reviewed related anti-PD-(L)1 immunotherapy whether they ruled out increased loads...