A5017340351- Head and Neck Cancer Studies
- Lung Cancer Treatments and Mutations
- Sarcoma Diagnosis and Treatment
- Salivary Gland Tumors Diagnosis and Treatment
- Tumors and Oncological Cases
- Cervical Cancer and HPV Research
- Ear and Head Tumors
- Cancer Genomics and Diagnostics
- Bone Tumor Diagnosis and Treatments
- Soft tissue tumor case studies
- Cancer Diagnosis and Treatment
- Oral and Maxillofacial Pathology
- Cancer Immunotherapy and Biomarkers
- Head and Neck Surgical Oncology
- Colorectal and Anal Carcinomas
- Vascular Tumors and Angiosarcomas
- Cancer and Skin Lesions
- Thyroid Cancer Diagnosis and Treatment
- Chromatin Remodeling and Cancer
- Cardiac tumors and thrombi
- Head and Neck Anomalies
- IgG4-Related and Inflammatory Diseases
- Neurofibromatosis and Schwannoma Cases
- Histiocytic Disorders and Treatments
- Cancer-related molecular mechanisms research
Brigham and Women's Hospital
2015-2024
Harvard University
2015-2024
University Medical Center
2024
The University of Texas Southwestern Medical Center
2024
Urology Associates of North Texas
2024
National Cancer Institute
2024
Southwestern Medical Center
2024
University of California, Los Angeles
2024
Dana-Farber Cancer Institute
2020-2024
Dana-Farber Brigham Cancer Center
2023
Fine-needle aspiration (FNA) is an important test for triaging patients with thyroid nodules. The 2007 National Cancer Institute Thyroid Fine-Needle Aspiration State-of-the-Science Conference helped instigate the recent publication of Bethesda System Reporting Cytopathology. We reviewed 3,080 FNA samples and recorded interpretations according to proposed standardized 6-tier nomenclature, pursued follow-up cytology histology. Of FNAs, 18.6% were nondiagnostic, 59.0% benign, 3.4% atypical...
Novel approaches are needed to improve outcomes in patients with squamous cell carcinoma of the oral cavity. Neoadjuvant immunotherapy given prior surgery and combining programmed death protein 1 (PD-1) cytotoxic T-lymphocyte-associated 4 (CTLA-4) immune checkpoint inhibitors 2 strategies enhance antitumor responses that could be benefit.
Pembrolizumab improved survival in patients with recurrent or metastatic head and neck squamous-cell carcinoma (HNSCC). The aims of this study were to determine if pembrolizumab would be safe, result pathologic tumor response (pTR), lower the relapse rate resectable human papillomavirus (HPV)-unrelated HNSCC.Neoadjuvant (200 mg) was administered followed 2 3 weeks later by surgical ablation. Postoperative (chemo)radiation planned. Patients high-risk pathology (positive margins and/or...
About 50% of patients with locally advanced head and neck squamous cell carcinoma (HNSCC) experience recurrences after definitive therapy. The presurgical administration anti-programmed death protein 1 (PD-1) immunotherapy results in substantial pathologic tumor responses (pTR) within the microenvironment (TME). However, mechanisms underlying dynamics antitumor T cells upon neoadjuvant PD-1 blockade remain unresolved, approaches to increase are lacking. In a phase 2 trial (NCT02296684), we...
Leiomyosarcoma is a malignant neoplasm with smooth muscle differentiation. Little known about its molecular heterogeneity and no targeted therapy currently exists for leiomyosarcoma. Recognition of different subtypes necessary to evaluate novel therapeutic options. In previous study on 51 leiomyosarcomas, we identified three in The current was performed determine whether the existence these could be confirmed independent cohorts.Ninety-nine cases leiomyosarcoma were expression profiled 3'end...
Papillary squamous cell carcinoma (SCC) is an uncommon variant of SCC in the upper aerodigestive tract. It most frequently located larynx, oropharynx, and sinonasal tract, more common older men. Because its complex exophytic papillary architecture, histologic assessment underlying invasion can be challenging. Risk factors pathogenesis are unclear. We reviewed 31 SCCs tract seen at our institution over a 17-year period with respect to p16 immunoreactivity human papillomavirus (HPV) status....
Epithelioid malignant peripheral nerve sheath tumor (EMPNST) is rare and differs from conventional by showing diffuse S-100 protein positivity, infrequent association with NF1, occasional origin in a schwannoma. Loss of INI1 expression seen subset tumors. The purpose this study was to further define clinicopathologic features outcome data large series EMPNST. Sixty-three cases were identified consultation files. patient group consisted 33 men 30 women; the median age 44 years (range, 6 80...
The term noninvasive follicular thyroid neoplasm with papillary-like nuclear features (NIFTP) has been proposed to replace variant of papillary carcinoma (FVPTC) in recognition the indolent behavior this tumor. ability differentiate NIFTP from classical (cPTC) by fine-needle aspiration (FNA) would facilitate conservative management for NIFTP. aim study was determine if can be distinguished prospectively cPTC.From June 2015 January 2016, FNAs a diagnosis "malignant" or "suspicious malignancy"...
Cutaneous myoepithelial tumors demonstrate heterogenous morphologic and immunophenotypic features. We previously described, in brief, 7 cases of cutaneous myoepithelioma showing solid syncytial growth ovoid, spindled, or histiocytoid cells. now present the clinicopathologic features a series 38 this distinctive variant, which were diagnosed between 1997 2012 (mostly seen consultation). There 27 men 11 women, with median age 39 years (range, 2 mo to 74 y). Primary anatomic sites upper...
Salivary gland basaloid neoplasms are diagnostically challenging. Limited publications report that some basal cell adenomas harbor CTNNB1 mutations, and nuclear β-catenin expression is prevalent. We evaluated in adenocarcinomas comparison with salivary tumors the differential diagnosis performed targeted genetic analysis on a subset of cases. immunohistochemistry was formalin-fixed, paraffin-embedded whole sections from 73 tumors. Nuclear staining scored semiquantitatively by extent...
Surgery often represents the best chance for disease control in locoregionally recurrent squamous cell carcinoma of head and neck (SCCHN). We investigated dual immune-checkpoint inhibition [anti-PD-1, nivolumab (N), anti-KIR, lirilumab (L)] before after salvage surgery to improve disease-free survival (DFS).
Circulating tumor tissue-modified viral (TTMV) human papillomavirus (HPV) DNA is a dynamic, clinically relevant biomarker for HPV-positive oropharyngeal squamous cell carcinoma. Reasons its wide pretreatment interpatient variability are not well understood.To characterize clinicopathologic factors associated with TTMV HPV DNA.This cross-sectional study included patients evaluated carcinoma at Dana-Farber Cancer Institute in Boston, Massachusetts, between December 2019 and January 2022 who...
Proliferative verrucous leukoplakia (PVL) is an aggressive oral precancerous disease characterized by a high risk of transformation to invasive squamous cell carcinoma (OSCC), and no therapies have been shown affect its natural history. A recent study the PVL immune landscape revealed cytotoxic T-cell-rich microenvironment, providing strong rationale investigate checkpoint therapy.
p63 is a p53 homolog that expressed in various normal epithelial tissues and malignancies. Its expression mesenchymal lesions has not been examined depth; therefore, we studied by immunohistochemical analysis 650 soft tissue tumors. We found limited The majority of tumors were p63–, including all cases angiosarcoma, lipomatous neoplasms, dermatofibrosarcoma protuberans, solitary fibrous tumor, schwannoma, neurofibroma, gastrointestinal stromal leiomyosarcoma. Nuclear reactivity was subset...
The epithelioid variant of schwannoma is rare, and loss SMARCB1/INI1 expression has been observed in a subset cases. Our aim was to further define the clinicopathologic features evaluate deficiency large cohort 65 schwannomas diagnosed between 2002 2015, which consisted 32 men 33 women with median age at diagnosis 45 years (range, 13 75 y). Most tumors arose extremities (upper, 20, lower, 15) trunk (17); 9 were visceral (8 gastrointestinal). somatic dermis/subcutis (53/54) encapsulated an...
BACKGROUND Adenocarcinoma can be challenging to distinguish from malignant mesothelioma in effusions, and this distinction often requires ancillary studies clinical correlation. Immunohistochemistry for claudin‐4, a tight‐junction‐associated protein, has recently been shown adenocarcinoma mesothelioma, mostly surgical specimens. Our aim was validate assess the immunoreactivity profile of claudin‐4 large series effusions. METHODS We evaluated 159 effusions (84 adenocarcinomas 75...
Aims Accurate classification of salivary gland neoplasms may be challenging, owing to morphological overlap, particularly in small biopsies. Recurrent translocations involving the high‐mobility group AT ‐hook 2 ( HMGA 2) gene are present a subset pleomorphic adenomas PA s) and carcinoma ex‐pleomorphic CA ex‐ s). The aim this study was evaluate immunohistochemical expression 225 tumours, including 56 s, 37 132 potential histological mimics, determine its diagnostic utility. Methods results...
Adamantinoma-like Ewing sarcoma (ALES) is a rare tumor that demonstrates the EWSR1-FLI1 translocation characteristic of despite overt epithelial differentiation including diffuse expression cytokeratins and p40. Most cases ALES described to date have occurred in head neck where they can mimic wide range small round blue cell tumors. Because distinguishing from basaloid salivary gland carcinomas be particularly difficult, we analyzed series 10 ALESs glands with aim identifying features allow...