A5031720297- Cancer Cells and Metastasis
- Cancer Genomics and Diagnostics
- Lung Cancer Treatments and Mutations
- HER2/EGFR in Cancer Research
- Pancreatic and Hepatic Oncology Research
- Lung Cancer Diagnosis and Treatment
- Renal and related cancers
- Cancer Research and Treatments
- Radiomics and Machine Learning in Medical Imaging
- AI in cancer detection
- Generative Adversarial Networks and Image Synthesis
- Ecology and Conservation Studies
- Breast Cancer Treatment Studies
- Ovarian cancer diagnosis and treatment
- Renal cell carcinoma treatment
- Thyroid Cancer Diagnosis and Treatment
- Advanced Image Processing Techniques
- Brain Metastases and Treatment
- Cancer Treatment and Pharmacology
- Salivary Gland Tumors Diagnosis and Treatment
- Lung Cancer Research Studies
- Prostate Cancer Treatment and Research
- Cancer, Hypoxia, and Metabolism
- Monoclonal and Polyclonal Antibodies Research
- Histone Deacetylase Inhibitors Research
Stanford University
2019-2025
Brigham and Women's Hospital
2015-2025
Harvard University
2012-2025
Beth Israel Deaconess Medical Center
2023-2024
Massachusetts General Hospital
2016-2024
The University of Texas MD Anderson Cancer Center
2019-2024
Università Cattolica del Sacro Cuore
2019-2024
Stanford Health Care
2023-2024
Stanford Medicine
2020-2024
Palo Alto University
2024
Evidence-based treatments for metastatic, human epidermal growth factor receptor 2 (HER2)-positive breast cancer in the CNS are limited. Neratinib is an irreversible inhibitor of erbB1, HER2, and erbB4, with promising activity HER2-positive cancer; however, its unknown. We evaluated efficacy treatment neratinib patients brain metastases a multicenter, phase II open-label trial.Eligible were those (≥ 1 cm longest dimension) who experienced progression after one or more line CNS-directed...
The term noninvasive follicular thyroid neoplasm with papillary-like nuclear features (NIFTP) has been proposed to replace variant of papillary carcinoma (FVPTC) in recognition the indolent behavior this tumor. ability differentiate NIFTP from classical (cPTC) by fine-needle aspiration (FNA) would facilitate conservative management for NIFTP. aim study was determine if can be distinguished prospectively cPTC.From June 2015 January 2016, FNAs a diagnosis "malignant" or "suspicious malignancy"...
<h3>Importance</h3> Histopathological diagnoses of tumors from tissue biopsy after hematoxylin and eosin (H&E) dye staining is the criterion standard for oncological care, but H&E requires trained operators, dyes reagents, precious samples that cannot be reused. <h3>Objectives</h3> To use deep learning algorithms to develop models perform accurate computational native nonstained prostate core images methods interpretation analysis computationally stained by computer vision clinical...
Accurate determination of HER2/neu status in breast carcinoma is essential. Alteration preanalytic variables known to affect results. American Society Clinical Oncology (ASCO) and the College Pathologists (CAP) issued guidelines standardize fixation for increased accuracy. We studied effects changing on immunohistochemical fluorescence situ hybridization (FISH) results a HER2/neu+ invasive carcinoma. The clinical specimen was processed according ASCO/CAP guidelines, with remaining tumor...
Histopathology tissue samples are widely available in two states: paraffin-embedded unstained and non-paraffin-embedded stained whole slide RGB images (WSRI). Hematoxylin eosin stain (H&E) is one of the principal stains histology but suffers from several shortcomings related to preparation, staining protocols, slowness human error. We report novel approaches for training machine learning models computational H&E destaining prostate core biopsy images. The model uses a conditional generative...
Accurate determination of estrogen receptor (ER) and progesterone (PR) status in breast carcinoma is essential. Preanalytic variation may contribute to discordant results. Recently, American Society Clinical Oncology (ASCO)/College Pathologists (CAP) made recommendations normalize fixation for biomarkers. To evaluate this, a 4-cm invasive lobular was processed according ASCO/CAP guidelines. The remainder stored fresh at 4°C 4 days cut into biopsy-sized pieces. Each fixed 10% formalin,...
Abstract Background Fumarate hydratase‐deficient renal cell carcinoma (FHRCC) is an aggressive that typically presents as advanced‐stage disease. Prompt recognition of FHRCC critical for appropriate clinical care and genetic counseling patients family members. However, diagnosing from cytology specimens challenging, with limited characterization no reports describing prospectively identified cases. Methods Cytology fine‐needle aspiration (FNA) cases diagnosed were reviewed, including two...
Cellular therapies offer a promising therapeutic strategy for the highly malignant brain tumor, glioblastoma (GBM). However, their clinical translation is limited by lack of effective target identification and stringent testing in pre-clinical models that replicate standard treatment GBM patients. In this study, we show detection cell surface death receptor (DR) on CD146-enriched circulating tumor cells (CTC) captured from blood mice bearing patients diagnosed with GBM. Next, developed...
Rationale: Unlike traditional biopsy, liquid which is a largely non-invasive diagnostic and monitoring tool, can be performed more frequently to better track tumors mutations over time validate the efficiency of cancer treatment. Circulating tumor cells (CTCs) are considered promising biopsy biomarkers; however, their use in clinical settings limited by high costs low throughput standard platforms for CTC enumeration analysis. In this study, we used label-free, high-throughput method...
PURPOSE Radium-223 improves overall survival (OS) and reduces skeletal events in patients with bone metastatic castration-resistant prostate cancer (CRPC), but relevant biomarkers are lacking. We evaluated automated scan index (aBSI) circulating tumor cell (CTC) analyses as potential of prognosis activity. PATIENTS AND METHODS Patients CRPC were enrolled on a prospective single-arm study standard radium-223. 99m Tc-MDP images at baseline, 2 months, 6 months quantitated using aBSI. CTCs 1...
Background Hürthle cell metaplasia is common in hyperplastic nodules, particularly within the setting of lymphocytic thyroiditis (LT). The Bethesda System for Reporting Thyroid Cytopathology indicates that it acceptable to classify cell–predominant fine‐needle aspiration (HC FNA) specimens as atypia undetermined significance (AUS) rather than suspicious a neoplasm (HUR) multiple nodules or known LT. goal current study was address whether this approach justified. Methods HC FNA were...
BACKGROUND The circulating tumor cell (CTC) field is rapidly advancing with the advent of continuously improving technologies for enriching these rare neoplastic cells from blood. CTC enumeration provides prognostic information, and characterization has potential to provide more useful information clinical decision‐making process in this era personalized medicine targeted therapeutics. Proof‐of‐principle studies have shown that samples can be characterized a variety techniques research...