A5063884420- SARS-CoV-2 and COVID-19 Research
- COVID-19 Clinical Research Studies
- Bacterial Identification and Susceptibility Testing
- Long-Term Effects of COVID-19
- Antimicrobial Resistance in Staphylococcus
- Antibiotic Resistance in Bacteria
- COVID-19 and healthcare impacts
- COVID-19 and Mental Health
- Antifungal resistance and susceptibility
- Neutropenia and Cancer Infections
- Fungal Infections and Studies
- SARS-CoV-2 detection and testing
- Antibiotics Pharmacokinetics and Efficacy
- Antibiotic Use and Resistance
- Cancer Immunotherapy and Biomarkers
- Infective Endocarditis Diagnosis and Management
- Immunotherapy and Immune Responses
- Streptococcal Infections and Treatments
- Respiratory viral infections research
- Urinary Tract Infections Management
- Infection Control and Ventilation
- Tuberculosis Research and Epidemiology
- Mycobacterium research and diagnosis
- COVID-19 Impact on Reproduction
- Immune Cell Function and Interaction
Seoul National University
2015-2025
Seoul National University Hospital
2013-2025
New Generation University College
2020-2025
National University College
2023
Seoul National University Bundang Hospital
2013-2020
Pusan National University
2020
The University of Texas Southwestern Medical Center
2020
Jeonbuk National University
2018
Korea Institute of Science & Technology Information
2013
Background: Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)-infected pneumonia emerged in Wuhan, China December 2019.In this retrospective multicenter study, we investigated the clinical course and outcomes of novel disease 2019 (COVID-19) from early cases Republic Korea.Methods: All confirmed by real time polymerase chain reaction were enrolled 1st to 28th patient nationwide.Clinical data collected analyzed for changes severity including laboratory, radiological, virologic...
Novel coronavirus (SARS-CoV-2) is found to cause a large outbreak started from Wuhan since December 2019 in China and SARS-CoV-2 infections have been reported with epidemiological linkage 25 countries until now.We isolated the oropharyngeal sample obtained patient first laboratory-confirmed infection Korea.Cytopathic effects of Vero cell cultures were confluent 3 days after blind passage sample.Coronavirus was confirmed spherical particle having fringe reminiscent crown on transmission...
Acquired somatic mutations in hematopoietic stem and progenitor cells (clonal hematopoiesis or CH) are associated with advanced age, increased risk of cardiovascular malignant diseases, decreased overall survival. These adverse sequelae may be mediated by altered inflammatory profiles observed patients CH. A pro-inflammatory immunologic profile is also worse outcomes certain infections, including SARS-CoV-2 its disease Covid-19. Whether CH predisposes to severe Covid-19 other infections...
We investigated the kinetics of severe acute respiratory syndrome coronavirus 2 neutralizing antibodies in 7 asymptomatic persons and 11 patients with pneumonia. The geometric mean titer declined from 219.4 at months to 143.7 5 after infection, indicating a waning antibody response.
Abstract Waning humoral immunity in coronavirus disease patients has raised concern over usefulness of serologic testing. We investigated antibody responses 58 persons 8 months after asymptomatic or mildly symptomatic infection with severe acute respiratory syndrome 2. For 3 4 immunoassays used, seropositivity rates were high (69.0%–91.4%).
Clinical and Epidemiologic Characteristics of Spreaders Middle East Respiratory Syndrome Coronavirus during the 2015 Outbreak in Korea Nosocomial transmission is an important characteristic (MERS-CoV) infection.Risk factors for MERS-CoV healthcare settings are not well defined.During Korean outbreak 2015, 186 patients had laboratory-confirmed infection.Those suspected as a source viral were categorized into spreader groups (super-spreader [n = 5] usualspreader 10]) compared to non-spreader...
Stereotypic antibody clonotypes exist in healthy individuals and may provide protective immunity against viral infections by neutralization. We observed that 13 of 17 patients with COVID-19 had stereotypic variable heavy chain (V
ObjectivesWe hypothesized that immune response may contribute to progression of coronavirus disease-19 (COVID-19) at the second week illness. Therefore, we compared cell-mediated (CMI) responses between severe and mild COVID-19 cases.MethodsWe examined peripheral blood mononuclear cells laboratory-confirmed patients from their first third weeks Severe pneumonia was defined as an oxygen saturation ≤93% room air. Expressions molecules related T-cell activation functions were analyzed by flow...
Echinococcosis, caused by the tapeworm Echinococcus, is rare in Korea and primarily imported from endemic areas. We report a case of 37-year-old Korean man with multiple large hepatic cysts, initially diagnosed as simple cysts at local clinic 2018. The patient had lived Oman, an area, for several months 2016. Upon referral to tertiary hospital 2023, due progressive cyst enlargement, liver magnetic resonance imaging revealed three water lily sign. Serum IgG against Echinococcus was positive...
Background/Aims As the coronavirus disease-2019 global pandemic progresses, screening of antiviral agents effective against severe acute respiratory syndrome 2 (SARS-CoV-2) is urgently needed. In addition, considering viral load kinetics SARS-CoV-2, which peaks early in illness, and massive burden disease, may increase near future, identifying well-tolerated oral antivirals becomes increasingly important. We examined vitro activity lopinavir/ritonavir hydroxychloroquine on at concentrations...
Phages and their derivatives are increasingly being reconsidered for use in the treatment of bacterial infections due to rising rates antibiotic resistance. We assessed antistaphylococcal effect endolysin SAL200 combination with standard-of-care (SOC) antibiotics.
This study aimed to assess the association between local and systemic reactogenicity humoral immunogenicity after severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) vaccination.Adverse events were prospectively evaluated using an electronic diary in 135 healthy adults who received a SARS-CoV-2 vaccine (AZD1222, AstraZeneca/Oxford, n = 42; or BNT162b2, Pfizer/BioNTech, 93). We semi-quantitatively measured anti-S1 immunoglobulin G (IgG) enzyme-linked immunosorbent assay at baseline,...
Abstract Background Understanding the memory T-cell response to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is crucial for assessing longevity of protective immunity after SARS-CoV-2 infection or disease 2019 (COVID-19) vaccination. However, longitudinal up 8 months post–symptom onset (PSO) according severity illness unknown. Methods We analyzed peripheral blood mononuclear cells (PBMCs) from healthy volunteers patients with COVID-19 who experienced asymptomatic, mild, at 2,...
Although statins are widely prescribed lipid-lowering drugs, there concerns about the safety of their use in context coronavirus disease 2019 (COVID-19), since increase expression ACE2 (angiotensin-converting enzyme 2). This study aimed to disclose association between and 60-day COVID-19 mortality. Approach Results: All patients hospitalized with laboratory-confirmed were enrolled this from January 19 April 16, 2020, Korea. We evaluated COVID-19-related mortality overall nested 1:2...
As the coronavirus disease 2019 (COVID-19) pandemic is ongoing, heavy workload of healthcare workers (HCWs) a concern. This study investigated HCWs responding to COVID-19 outbreak in South Korea.A nationwide cross-sectional survey was conducted from September 16 October 15, 2020, involving facilities (4 public medical centers, 12 tertiary-care hospitals) that provide treatment for patients.Public centers provided majority (69.4%) total hospital beds patients (n = 611), on other hand,...
Abstract Burnout is a form of negative emotional and physical response to job stress. This study aimed investigate the prevalence burnout among healthcare workers responding coronavirus disease 2019 (COVID-19) outbreak in Korea explore correlates workers. A nationwide questionnaire-based survey was conducted from December 1, 2020, January 29, 2021 on 1425 who worked one 16 facilities designated for COVID-19 care, public health centers, or as paramedics Korea. assessed using Korean-adapted...
The immune escape of Omicron variants significantly subsides by the third dose an mRNA vaccine. However, it is unclear how variant-neutralizing antibodies develop under repeated vaccination. We analyze blood samples from 41 BNT162b2 vaccinees following course three injections and their B-cell receptor (BCR) repertoires at six time points in total. concomitant reactivity to both ancestral receptor-binding domain (RBD) achieved a limited number BCR clonotypes depending on accumulation somatic...
Recently, the number of patients with coronavirus disease 2019 (COVID-19) who have tested positive for severe acute respiratory syndrome 2 (SARS-CoV-2), via reverse transcription polymerase chain reaction (RT-PCR) test, after recovery has increased; this caused a dilemma regarding medical measures and policies. We evaluated dynamics viral load anti-SARS-CoV-2 antibodies in four RT-PCR results recovery. In all patients, highest levels immunoglobulin G (IgG) IgM were reached about month onset...
SAL200 is derived from a phage endolysin and novel candidate drug for the treatment of Staphylococcus aureus infection. We investigated efficacy recombinant in lethal murine pneumonia model. Lethal was established by intranasally administering methicillin-susceptible (Newman) or methicillin-resistant (LAC) S. strain into BALB/c mice. The mice were treated with single intranasal administration phosphate-buffered saline at 2 h after survival rates recorded until 60 bacterial challenge. loads...