A5074677757- Antimicrobial Resistance in Staphylococcus
- Antibiotic Resistance in Bacteria
- Bacterial Identification and Susceptibility Testing
- Streptococcal Infections and Treatments
- Antibiotic Use and Resistance
- Urinary Tract Infections Management
- HIV/AIDS Research and Interventions
- COVID-19 Clinical Research Studies
- Infective Endocarditis Diagnosis and Management
- SARS-CoV-2 and COVID-19 Research
- HIV/AIDS drug development and treatment
- Antifungal resistance and susceptibility
- Healthcare professionals’ stress and burnout
- Bacterial biofilms and quorum sensing
- Antibiotics Pharmacokinetics and Efficacy
- COVID-19 and Mental Health
- Cardiac Structural Anomalies and Repair
- Long-Term Effects of COVID-19
- Hepatitis C virus research
- Viral-associated cancers and disorders
- Fungal Infections and Studies
- Clostridium difficile and Clostridium perfringens research
- Bacteriophages and microbial interactions
- Mycobacterium research and diagnosis
- Plant Gene Expression Analysis
Pusan National University Hospital
2016-2025
Pusan National University
2010-2024
Konkuk University
2021-2024
Westmead Institute for Medical Research
2023
Seoul National University Bundang Hospital
2016-2022
Busan Medical Center
2020
The Busan Metropolitan Simin Municipal Library
2020
Daegu Fatima Hospital
2012-2019
Jungwon University
2012-2015
Samsung (South Korea)
2012
About 20% of methicillin-susceptible Staphylococcus aureus (MSSA) isolates have a substantial inoculum effect with cefazolin, suggesting that cefazolin treatment may be associated clinical failure for serious MSSA infections. There are no well-matched controlled studies comparing nafcillin the bacteremia. A retrospective propensity-score-matched case-control study was performed from 2004 to 2009 in tertiary care hospital where unavailable August 2006. The group (n = 49) included...
Background. Persistent methicillin-resistant Staphylococcus aureus (MRSA) bacteremia is associated with high mortality rates, but no treatment strategy has yet been established. We performed this study to evaluate the efficacy of linezolid or without carbapenem in salvage for persistent MRSA bacteremia.
As the coronavirus disease 2019 (COVID-19) pandemic is ongoing, heavy workload of healthcare workers (HCWs) a concern. This study investigated HCWs responding to COVID-19 outbreak in South Korea.A nationwide cross-sectional survey was conducted from September 16 October 15, 2020, involving facilities (4 public medical centers, 12 tertiary-care hospitals) that provide treatment for patients.Public centers provided majority (69.4%) total hospital beds patients (n = 611), on other hand,...
Abstract Burnout is a form of negative emotional and physical response to job stress. This study aimed investigate the prevalence burnout among healthcare workers responding coronavirus disease 2019 (COVID-19) outbreak in Korea explore correlates workers. A nationwide questionnaire-based survey was conducted from December 1, 2020, January 29, 2021 on 1425 who worked one 16 facilities designated for COVID-19 care, public health centers, or as paramedics Korea. assessed using Korean-adapted...
Human leukocyte antigen allele (HLA)–B*5701 is associated with abacavir hypersensitivity. However, the carriage rate of HLA-B*5701 has rarely been studied in Asians. In 534 Korean patients human immunodeficiency virus infection, status was determined by polymerase chain reaction HLA-B*5701–specific primers. No had (95% confidence interval, 0%–0.7%). This explains paucity immunologically confirmed cases hypersensitivity Koreans.
Background: Blood culture contamination leads to inappropriate or unnecessary antibiotic use. However, practical guidelines are inconsistent about the routine use of sterile gloving in collection blood for culture. Objective: To determine whether before venipuncture reduces rates. Design: Cluster randomized, assessor-blinded, crossover trial (ClinicalTrials.gov registration number: NCT00973063). Setting: Single-center involving medical wards and intensive care unit. Participants: 64 interns...
Although the incidence of non-Aspergillus filamentous fungal infections has increased, there is little data regarding correlation between results histologic analysis and those microbiologic culture in clinical practice. We investigated cultures inoculated with tissue specimens that had been found to have hyphae on examination at a university-affiliated tertiary care hospital. Culture studies were requested for diagnosis 122 (31%) 393 patients evidence presence infections. In 53 (43.4%) out...
Cefazolin is a common antibiotic for methicillin-susceptible Staphylococcus aureus (MSSA) bacteremia. Type A or C β-lactamase-producing MSSA frequently shows the cefazolin inoculum effect (CIE). However, clinical implication of CIE bacteremia obscure.MSSA bacteremic patients treated with were included in retrospective cohort study. The blaZ gene isolates was sequenced to identify type β-lactamase. whose showed ≥4-fold increase cefazolin, minimal inhibitory concentration (MIC) at high...
We estimated the nationwide burden of nosocomial S. aureus bloodstream infection (SA-BSI), a major cause infection, in South Korea. To evaluate incidence SA-BSI, cases SA-BSI were prospectively collected from 22 hospitals with over 500 beds 4?months. Data on patient-days obtained national health insurance database containing claims data for all healthcare facilities The additional cost was through matched case?control study. economic calculated sum medical costs, costs caregiving and loss...
Poor adherence with oral bisphosphonates (BPs) can mitigate their therapeutic benefit for osteoporosis and is a significant clinical burden. Most previous studies regarding BPs have focused on postmenopausal osteoporosis, but little attention has been given to patients rheumatoid arthritis (RA). Thus, we investigated compliance persistence in the treatment of analyzed risk factors poor female (RA) real setting. This retrospective longitudinal study including 396 RA whom were newly initiated...
The socioeconomic and clinical burden of multidrug-resistant organisms (MDRO), including methicillin-resistant Staphylococcus aureus (MRSA), vancomycin-resistant enterococci (VRE), Acinetobacter baumannii (MRAB), Pseudomonas aeruginosa (MRPA), carbapenem-resistant Enterobacteriaceae (CRE) have not yet been adequately addressed. We prospectively searched for MDRO bacteremia cases with matched controls from 10 hospitals across Korea during a 6-month period in 2017. Patients were classified...
Antimicrobial prescriptions for serious chronic or acute illness nearing its end stages raise concerns about the potential futile use, adverse events, increased multidrug-resistant organisms, and significant patient social cost burdens. This study investigated nationwide situation of how antibiotics are prescribed to patients during last 14 days life guide future actions.This multicenter retrospective cohort was conducted at 13 hospitals in South Korea from November 1 December 31, 2018. All...
This study compared the efficacy of cefazolin in a mouse pneumonia model caused by methicillin-susceptible Staphylococcus aureus (MSSA) strain with inoculum effect (CIE) and its blaZ-eliminated derivative. An isogenic blaZ gene-eliminated was derived from type A blaZ-positive MSSA blood isolates exhibiting CIE: PNIDSA230 (parental strain, CIE+) PNIDSA230c (blaZ-eliminated CIE-). Mice were inoculated 2 × 10⁶ to 10⁷ cfu via endotracheal tubes treated intraperitoneal or oxacillin 5 h...
Successful empirical therapy of Staphylococcus aureus infections requires the ability to predict methicillin resistance. Our aim was identify predictors resistance in community-onset (CO) invasive S. infections. Sixteen hospitals across Korea participated this study from May December 2012. We prospectively included cases infection which isolated sterile clinical specimens ≤ 72 hours after hospitalization. Clinical and epidemiological data were gathered compared methicillin-resistant (MRSA)...
: A 54-year-old man with Middle East respiratory syndrome coronavirus (MERS-CoV) infection was transferred to our hospital. We initiated anti-viral drugs and supportive care. The patient's fever chills disappeared 3 days after admission the results of serial follow-up reverse transcription-polymerase chain reaction testing for MERS-CoV negative soon thereafter. He discharged from hospital 14 no symptoms; however, he presented a 7 discharge re-hospitalized. Chest radiographs showed newly...
The optimal treatment option for carbapenem-resistant Acinetobacter baumannii (CRAB) is still limited. This study investigated the efficacy of three or more antibiotic types and regimens CRAB infection in high endemic areas.A multicentre retrospective was conducted to evaluate infections 10 tertiary hospitals Republic Korea. outcomes comprised 7-day 28-day mortality, clinical microbiological responses at 7 days, 28 end treatment. Nephrotoxicity hepatotoxicity were evaluated as drug adverse...
Regdanvimab (CT-P59) is a neutralizing antibody authorized in Republic of Korea for the treatment adult patients with moderate or mild-COVID-19 who are not on supplemental oxygen and have high risk progressing to severe disease (age ≥ 50 years comorbidities). This study evaluated clinical efficacy, safety medical utilization/costs associated real-world regdanvimab therapy.This non-interventional, retrospective cohort included confirmed mild-to-moderate SARS-CoV-2 infection. Patients treated...
A healthcare system's collapse due to a pandemic, such as the coronavirus disease 2019 (COVID-19), can expose workers (HCWs) various mental health problems. This study aimed investigate impact of COVID-19 pandemic on depression and anxiety HCWs.