A5058103007- Antimicrobial Resistance in Staphylococcus
- Bacterial Identification and Susceptibility Testing
- Antibiotic Resistance in Bacteria
- HIV/AIDS drug development and treatment
- Mycobacterium research and diagnosis
- HIV Research and Treatment
- HIV/AIDS Research and Interventions
- Pneumocystis jirovecii pneumonia detection and treatment
- Infective Endocarditis Diagnosis and Management
- Fungal Infections and Studies
- Urinary Tract Infections Management
- Cytomegalovirus and herpesvirus research
- Infectious Diseases and Tuberculosis
- Respiratory viral infections research
- SARS-CoV-2 and COVID-19 Research
- Bacterial biofilms and quorum sensing
- Tuberculosis Research and Epidemiology
- Herpesvirus Infections and Treatments
- COVID-19 Clinical Research Studies
- Vector-borne infectious diseases
- Antifungal resistance and susceptibility
- Antibiotics Pharmacokinetics and Efficacy
- Streptococcal Infections and Treatments
- Nosocomial Infections in ICU
- Pneumonia and Respiratory Infections
Myongji Hospital
2020-2023
Hanyang University
2022-2023
Ajou University
2018
Armed Forces Capital Hospital
2011-2018
Korea University
2018
Chungbuk National University
2018
Seoul National University
2004-2016
Seoul National University Hospital
1999-2009
National University College
1999-2008
New Generation University College
1999-2008
The marked increase in the incidence of infections due to antibiotic-resistant gram-negative bacilli recent years is great concern, as patients infected by those isolates might initially receive antibiotics that are inactive against responsible pathogens. To evaluate effect inappropriate initial antimicrobial therapy on survival, a total 286 with bacteremia, 61 Escherichia coli 65 Klebsiella pneumoniae 74 Pseudomonas aeruginosa and 86 Enterobacter were analyzed retrospectively. If patient...
Since mid-December of 2019, coronavirus disease 2019 (COVID-19) infection has been spreading from Wuhan, China. The confirmed COVID-19 patients in South Korea are those who came or visited As secondary transmissions have occurred and the speed transmission is accelerating, there rising concerns about community infections. 54-year old male third patient diagnosed with Korea. He a worker for clothing business had mild respiratory symptoms intermittent fever beginning hospitalization, pneumonia...
Among the nosocomial pathogens, Pseudomonas aeruginosa is recognized as a major cause of morbidity and mortality. Data on 136 patients with P. bacteremia were retrospectively analyzed to evaluate risk factors for The median age was 55 years (range, 15-85 years), 78.7% cases hospital-acquired, 30-day mortality rate 39% (53 patients). Multivariate analysis demonstrated that included severe sepsis, pneumonia, delay in starting effective antimicrobial therapy, an increasing APACHE II score (all...
ABSTRACT Limited data on the clinical outcome of vancomycin treatment compared with that beta-lactam in patients methicillin-susceptible Staphylococcus aureus bacteremia (MSSA-B) are available. We used different and complementary approaches: (i) a retrospective cohort study using propensity score to adjust for confounding by assignment (ii) matched case-control study. Of all S. (SAB) two university-affiliated hospitals over 7-year period, 294 MSSA-B were enrolled The cases defined as who...
This study was conducted to evaluate risk factors for mortality and treatment outcome of bloodstream infections due extended-spectrum beta-lactamase (ESBL)-producing Escherichia coli Klebsiella pneumoniae (ESBL-EK). ESBL production in stored K. E. blood isolates from Jan 1998 Dec 2002 phenotypically determined according NCCLS guidelines and/or the double-disk synergy test. A total 133 patients with ESBL-EK bacteremia, including 66 ESBL-producing 67 coli, were enrolled. The overall 30-day...
ABSTRACT In order to define the contributions of mechanisms for carbapenem resistance in clinical strains Pseudomonas aeruginosa , we investigated presence OprD, expressions MexAB-OprM and MexEF-OprN systems, production β-lactamases 44 strains. All carbapenem-resistant isolates showed loss or decreased levels OprD. Three overexpressed efflux system by carrying mutations mexR . These three had amino acid substitution MexR protein, Arg (CGG) → Gln (CAG), at position 70. None isolates, however,...
Cases of bacteremia caused by AmpC-type-beta-lactamase-producing Klebsiella pneumoniae isolates were retrospectively studied to determine the epidemiologic features and clinical outcomes bloodstream infections. Among 389 blood recovered from 1998 2002, 65 (16.7%) found be extended-spectrum beta-lactamase (ESBL) or AmpC producers. The beta-lactamases 61 characterized; 28 produced AmpC-type enzymes (14 each DHA-1 CMY-1-like enzymes), 32 TEM SHV-related ESBLs, 1 isolate a CTX-M-14-like enzyme....
Scrub typhus, which is caused by Orientia tsutsugamushi, a systemic illness that causes generalized vasculitis. The central nervous system (CNS) the most crucial target in other rickettsial diseases; however, there have been several reports of encephalitis or meningitis without direct evidence invasion CNS cases scrub typhus. To investigate involvement we analyzed CSF profiles (cell count and levels protein glucose) amplified DNA specimens means nested polymerase chain reaction (PCR) for 25...
Abstract. Objective. To determine whether adherence to clinic visits early after initiation of highly active antiretroviral therapy (HAART) is predictive long‐term clinical outcome. Design. Observational cohort study. Setting. A tertiary referral hospital. Subjects. total 387 adult HIV patients who were followed for at least 1 year HAART between January 1998 and December 2004. Main outcome measurements. The effect 1‐year on the occurrence new AIDS‐defining illness or death was assessed using...
Methicillin-resistant Staphylococcus aureus (MRSA), originally restricted to hospitals, has emerged as a significant pathogen in the community. Although MRSA accounts for over 60% of S . tertiary hospitals Korea, little is known about epidemiology community-associated (CA-MRSA). From January July 2005, hospital laboratory-based survey was conducted seven community-based or hospitals. The medical records and Health Insurance Review Agency databases were reviewed isolated from patients without...
Staphylococcus aureus, one of the most frequently isolated pathogens in both hospitals and community, has been particularly efficient at developing resistance to antimicrobial agents. As methicillin-resistant S. aureus (MRSA) prevailed and, furthermore, as with reduced susceptibility vancomycin emerged, therapeutic options for treatment infections have become limited. To update current status antibiotic resistance, clinical isolates were collected from eight university-affiliated June 1999...
To determine the outcome of Staphylococcus aureus bacteremia (SAB) on mortality, including impact methicillin resistance and an initial delay (< or =48 h) appropriate antibiotics, a retrospective cohort study 238 patients with SAB was performed. By logistic regression, noneradicable noneradicated foci, underlying cirrhosis, cancer were found to be independent predictors mortality. In eradicable there no significant differences in associated mortality rate between methicillin-resistant (11%)...
Implication of Antimicrobial ResistanceWe conducted this study to compare clinical features, outcomes, and implication antimicrobial resistance in Klebsiella pneumoniae bacteremia acquired as community vs. nosocomial infection.A total 377 patients with K. (191 community-acquired 186 nosocomial) were retrospectively analyzed.Neoplastic diseases (hematologic malignancy solid tumor, 56%) the most commonly associated conditions bacteremia, whereas chronic liver disease (35%) diabetes mellitus...
Background. Persistent methicillin-resistant Staphylococcus aureus (MRSA) bacteremia is associated with high mortality rates, but no treatment strategy has yet been established. We performed this study to evaluate the efficacy of linezolid or without carbapenem in salvage for persistent MRSA bacteremia.
We performed a retrospective review of 126 cases infectious spondylodiscitis over 4-year period.Differentiation between pyogenic (PS) and tuberculous (TS) is essential for deciding on the appropriate therapeutic regimen. The aim this study was to compare characteristics 2 forms spondylodiscitis.There has been much effort distinguish radiologic findings in PS versus TS, but classification based alone had limitations yet.We compared predisposing factors or associated illnesses, clinical,...
ChAdOx1 and BNT162b2 vaccines are currently commonly used against coronavirus disease 2019 worldwide. Our study was designed to determine the serostatus relative levels of anti-S neutralizing antibodies in patients who were administered either or vaccine. In addition, we investigated whether antibody response each vaccine differed according sex age. Healthcare workers (HCWs) at a general hospital vaccinated with two doses invited participate this prospective cohort study. Blood samples HCWs...
Plasmodium vivax malaria reemerged in the Republic of Korea 1993 near Demilitarized Zone (DMZ). We reviewed clinical features 101 symptomatic patients with malaria. Of patients, 77 (76.3%) were veterans who had served DMZ; their median age was 23 years. The duration minimum latent period > 6 months 66.2% (51 77) (median, 278 days). Tertian fever developed 69 (68.3%). Severe thrombocytopenia platelet counts < 60,000/microL common (29.6% patients). parasite densities ranged 32-52,127...
Abstract Objective: To evaluate risk factors and treatment outcomes of bloodstream infections caused by extended-spectrum beta-lactamase-producing Klebsiella pneumoniae (ESBL-KP). Design: Retrospective case-control study. Stored blood isolates K. were tested for ESBL production NCCLS guidelines, double-disk synergy test, or both. Setting: A 1,500-bed, tertiary-care university hospital referral center. Patients: Sixty case-patients with bacteremia due to ESBL-KP compared 60 matched...
Two hundred ninety isolates of Escherichia coli were investigated for the production extended-spectrum beta-lactamases (ESBLs). Fourteen (4.8%) 290 strains found to produce ESBLs. Each 14 produced one or two ESBLs, as follows: 10 TEM-52, 1 strain SHV-2a, SHV-12, a CMY-1-like enzyme, and expressed SHV-2a enzyme. Another which MICs ceftazidime cefoxitin high, probable AmpC enzyme hyperproducers. Because high prevalence TEM-52 in E. isolates, we further TEM-type ESBLs by Klebsiella pneumoniae...
Enterobacter species have become increasingly important nosocomial pathogens. However, resistance to cephalosporins often complicates the treatment of infection. This study was conducted evaluate predictors mortality and impact cephalosporin on outcome in patients with bacteremia.A total 183 bacteremia were retrospectively analyzed. Broad-spectrum defined as vitro cefotaxime or ceftazidime. The main measure 30-day rate.Of patients, 86 (47%) had caused by broad-spectrum...
This study was conducted to evaluate risk factors for antimicrobial resistance and influence of on mortality in Pseudomonas aeruginosa bacteremia. Data 190 patients with P. bacteremia were analyzed retrospectively. Antimicrobial antipseudomonal antibiotics evaluated. The main outcome measure 30-day mortality. In bacteremia, rates piperacillin (PIP), ceftazidime (CAZ), ciprofloxacin (CIP), imipenem (IPM) 29 (56/190), 19 (36/190), 17 (32/190) 15% (28/190), respectively. Prior uses...
Clinical outcomes of spontaneous bacterial peritonitis (SBP) due to extended-spectrum beta-lactamase-producing Escherichia coli and Klebsiella species (ESBL-EK) have not been adequately investigated.We conducted a retrospective matched case-control study evaluate the SBP ESBL-EK compared with those non-ESBL-EK. Cases were defined as patients liver cirrhosis isolated from ascites. Control non-ESBL-EK in 3:1 ratio cases according following five variables: age (+/- 5 years); gender; infecting...