A5053847011- Cancer-related gene regulation
- Epigenetics and DNA Methylation
- Ubiquitin and proteasome pathways
- COVID-19 Clinical Research Studies
- SARS-CoV-2 and COVID-19 Research
- Peptidase Inhibition and Analysis
- Wnt/β-catenin signaling in development and cancer
- Microtubule and mitosis dynamics
- Genomics and Chromatin Dynamics
- Mechanisms of cancer metastasis
- Advanced biosensing and bioanalysis techniques
- Autophagy in Disease and Therapy
- Cancer Cells and Metastasis
- PI3K/AKT/mTOR signaling in cancer
- CRISPR and Genetic Engineering
- Estrogen and related hormone effects
- Chromosomal and Genetic Variations
- RNA modifications and cancer
- Genomics, phytochemicals, and oxidative stress
- Kruppel-like factors research
- Cytokine Signaling Pathways and Interactions
- Histone Deacetylase Inhibitors Research
- Cancer-related Molecular Pathways
- FOXO transcription factor regulation
- Single-cell and spatial transcriptomics
Gachon University
2021-2025
Seoul National University
2006-2021
Retinoic acid-related orphan receptor α (RORα) functions as a transcription factor for various biological processes, including circadian rhythm, cancer, and metabolism. Here, we generate intestinal epithelial cell (IEC)-specific RORα-deficient (RORα ΔIEC ) mice find that RORα is crucial maintaining homeostasis by attenuating nuclear κB (NF-κB) transcriptional activity. exhibit excessive inflammation highly activated inflammatory responses in the dextran sulfate sodium (DSS) mouse colitis...
Abstract Background Understanding the memory T-cell response to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is crucial for assessing longevity of protective immunity after SARS-CoV-2 infection or disease 2019 (COVID-19) vaccination. However, longitudinal up 8 months post–symptom onset (PSO) according severity illness unknown. Methods We analyzed peripheral blood mononuclear cells (PBMCs) from healthy volunteers patients with COVID-19 who experienced asymptomatic, mild, at 2,...
Abstract Autophagy is a catabolic process through which cytoplasmic components are degraded and recycled in response to various stresses including starvation. Recently, transcriptional epigenetic regulations of autophagy have emerged as essential mechanisms for maintaining homeostasis. Here, we identify that coactivator-associated arginine methyltransferase 1 (CARM1) methylates Pontin chromatin-remodeling factor under glucose starvation, methylated binds Forkhead Box O 3a (FOXO3a)....
Prostaglandin E2 (PGE2) is known to have a key role in the development of colorectal cancer, but previous experiments showed its contrasting (i.e. tumor-promoting or tumor-suppressive) roles depending on experimental conditions. To elucidate mechanisms underlying such PGE2 tumorigenesis, we investigated all and found new signal transduction pathway mediated by retinoic acid receptor-related orphan receptor (ROR)α, which PGE2/PKCα-dependent phosphorylation RORα attenuates Wnt target gene...
Abstract The fourth vaccination dose confers additional protective immunity against severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2) infection in individuals with no prior disease‐19 (COVID‐19). However, its immunological benefit currently circulating BA.4/5 is unclear who have received a booster shot and been infected Omicron variant BA.1/2. We analyzed immune responses whom had boosted once did not COVID‐19 ( n = 16), when BA.1/2 was dominant Korea (Hybrid‐6M group, 27), twice...
Mis18α, a component of Mis18 complex comprising Mis18β, and M18BP1, is known to localize at the centromere from late telophase early G1 phase plays priming role in CENP-A deposition. Although its deposition well established, other function Mis18α remains unknown. Here, we elucidate new that critical for proper progression cell cycle independent We find Aurora B kinase phosphorylates during mitosis not affecting neither localization nor loading CENP-A. However, replacement endogenous by...